2007
DOI: 10.1016/j.jnutbio.2006.11.011
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Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfκb1

Abstract: We hypothesized that the increase in mitochondrial proliferation in hearts from copper-deficient rats is due to an increase in expression of the transcriptional factor Ppargc1a, which regulates transcriptional activity for many of the genes that encode for mitochondrial proteins. In addition to several transcriptional factors implicated in mitochondrial biogenesis, we also looked at a number of genes involved in cell cycle regulation and fuel substrate utilization. Long-Evans rats were placed on either a coppe… Show more

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Cited by 8 publications
(3 citation statements)
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“…This glycoprotein possess in its promoter region a specific sequence to be regulated by NF- κ B DNA binding. Other NF- κ B-induced ECM proteins are elastins [45]. Nevertheless, fibrotic deposition depends on the balance between ECM proteins and ECM-degradation enzymes.…”
Section: Nf-κb and Diabetic Cardiomyopathymentioning
confidence: 99%
“…This glycoprotein possess in its promoter region a specific sequence to be regulated by NF- κ B DNA binding. Other NF- κ B-induced ECM proteins are elastins [45]. Nevertheless, fibrotic deposition depends on the balance between ECM proteins and ECM-degradation enzymes.…”
Section: Nf-κb and Diabetic Cardiomyopathymentioning
confidence: 99%
“… 46 Copper deficiency in animals leads to increased hepatic expression of genes involved in inflammation and fibrinogenesis 47 and also increases nuclear factor kappa beta-1. 48 Copper supplementation in rats fed a copper-deficient, high-sucrose diet restores beta-cell function and reduces pancreatic low-grade inflammation (reverses hyperglycemia and reduces the infiltration of fat and IL-1β-expressing macrophages). 49 Thus, copper has multiple actions for controlling inflammation including the rise in cereuloplasmin.…”
Section: Introductionmentioning
confidence: 99%
“…This is significant as NFkB is a transcription factor inducible NOS. The role of NFkB was shown to be robustly up-regulated in a recent paper our lab published [26]. Nisoli et al [27] reported that nitric oxide triggered mitochondrial biogenesis and that PGC-1α mediated this effect in a variety of cell types.…”
Section: Discussionmentioning
confidence: 96%