Differential Expression of Glutathione S-Transferases in Germ Cell Tumors of Human Testes

Institoris, Etel; Eid, Hanna; Bodrogi, I.; Bak, M.

doi:10.1097/00005392-199903000-00088

Cited by 2 publications

(1 citation statement)

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“…A lot of studies previously investigated the association of GSTM3 gene polymorphism with the risk to develop a lung cancer. Furthermore, a reduction in GST protein level was earlier reported in human TGCT (22), but the M3 isoform has not been previously identified in TGCT. Only proteomics permitted the identification of this specific isoform, as possibly associated with testis cancer.…”

Section: Proteomics Of Tgct Tissuementioning

confidence: 84%

Proteomics for the Identification of Biomarkers in Testicular Cancer–Review

et al. 2019

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A large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis of the full protein components of a single cell, of a specific tissue, or of biological fluids. In the last decades, proteomics has been applied in clinical fields, thanks to modern technology and new bioinformatic tools, to identify novel molecular markers of diseases. The aim of this review is to argue the findings of recent studies in the discoveries of putative prognostic and diagnostic markers of testis cancer by proteomic techniques. We present here a panel of proteins identified by proteomics which might be used after validation for early detection and the prognostic evaluation of testicular tumors. In addition, the molecular mechanisms revealed by these proteomic studies might also guide the development of novel treatments in future.

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Section: Proteomics Of Tgct Tissuementioning

confidence: 84%