Differential Expression of IGF‐I and IGF‐II in Eutopic and Ectopic Endometria of Women With Endometriosis and in Women Without Endometriosis

Sbracia, Marco; Zupi, Errico; Alò, Piero Luigi; Manna, Claudio; Marconi, Daniela; Scarpellini, F.; Grasso, J. A.; Tondo, U. Di; Romaninï, Carlo

doi:10.1111/j.1600-0897.1997.tb00238.x

Cited by 34 publications

(16 citation statements)

References 8 publications

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“…This is at variance with our study which showed that, while IGF-I was indeed decreased in endometriotic tissue, TGF b-1 was deexpressed. Also, an earlier study found that in eutopic endometria of women with endometriosis a reduction in IGF-I staining compared to normal was noted, whereas in the epithelial cells of fibrotic peritoneal adhesions an intense label for IGF-I was observed (Sbracia et al 1997). Another study demonstrated that IGF-I and IGF-II were present in both endometriotic and normal endometrium in equal amounts (Chang and Ho 1997).…”

Section: Discussionmentioning

confidence: 90%

Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium

et al. 2005

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A widely accepted theory of the etiology of endometriosis is that it originates from the implantation and invasion of cells from retrograde menstruation to various sites in the body particularly the pelvic peritoneal cavity. Little is known of the function of these cells in ectopic sites. Normal endometrium was compared with endometriotic tissue using an antibody to Placental Cadherin (P Cadherin), a recently studied cadherin that is implicated in metaplasia and early neoplasia and also 8-hydroxyguanine, an indicator of oxidative DNA damage. Comparisons of endometrial tissue function were made using expression of transforming growth factor beta-1 (TGFbeta-1) and insulin-like growth factor-I (IGF-I). There was no labelling for anti-P Cadherin or anti-8-hydroxydeoxyguanosine in normal endometrium but marked labelling for both on the apical surface of the endometriotic epithelium. Studies of markers of normal endometrial function were all de-expressed in endometriosis. This study indicates that endometriosis cells are abnormal and exhibit oxidative DNA damage, metaplasia and markedly reduced function compared to normal endometrium.

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Section: Discussionmentioning

confidence: 90%

Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium

et al. 2005

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“…In comparison with endometrium, the integrin alpha 3 subunit was up-regulated; the alpha 6 integrin subunit was down-regulated, and the cycle stage-dependent expression of alpha 5 and beta 3 was absent in endometriosis [111]. The expression pattern of IGF-II and IGF-I was different in endometrium and endometriosis, suggesting an alteration in cell proliferation and differentiation in endometriosis [112]. The expression of plasminogen and plasmin was cycle dependent in endometrium, was maintained continuously at a high level in endometriosis [113], suggesting that this could reflect the more invasive nature of the endometriotic implants.…”

Section: Are Endometriotic Cells Different From Endometrial Cells or mentioning

confidence: 86%

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Koninckx

Kennedy

1999

Gynecol Obstet Invest

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Peritoneal fluid is a specific microenvironment. It originates mainly as an ovarian exudation product due to increased vascular permeability, and contains large amounts of macrophages and their secretion products, which include growth factors, cytokines and angiogenic factors. Similarly, within the ovary, there is also a specific microenvironment, best characterised by the follicular milieu with steroid hormone concentrations that are 1,000 times higher than in plasma. Since endometrial cells in peritoneal fluid and superficially implanted cells will be influenced by peritoneal fluid concentrations, any differences found between minimal endometriosis and eutopic endometrium could be the consequence of their different local environments, rather than inherent cellular differences. Superficial endometrial implants may be regulated by factors in peritoneal fluid, while deep endometriosis and cystic ovarian endometriosis may be under the influence of factors in blood and within the ovary, in which case minimal endometriosis may be physiologic only, while deep endometriosis and cystic ovarian endometriosis, both associated with pelvic pain and infertility, may be a pathological state. In conclusion, the local endocrine environment, that is, in blood, peritoneal fluid, and within the ovary, should be taken into account to explain the differences between superficial, deep and cystic ovarian endometriosis, together with inherent differences in the endometrial cells of women with and without endometriosis.

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“…Some of the proposed hypothesis include-Retrograde menses theory of Sampson, Coelomic metaplasia theory and Mullerian embryonic rest theory. [515] Dysregulation of a number of genes including aromatase, progesterone receptor and angiogenic factors has been shown in some studies. [16] Growth factors have also been implicated in pathogenesis of endometriosis by promoting endometrial proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Effect of octreotide on endometriosis in acromegaly: Case report with review of literature

Singh

Chakravarty

Manchanda

et al. 2014

Indian J Endocr Metab

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Objective:To study the effect of octreotide therapy on endometriotic lesions in a patient with coexisting endometriosis and acromegaly.Intervention: Patient:A 34-year-old female was diagnosed with acromegaly and coexisting endometriosis. Post-surgical resection of the tumor, patient was initiated on octreotide therapy.Results:There was improvement in menstrual bleeding as IGF1 levels decreased with Octreotide therapy. Resolution of the endometriotic lesions was observed during follow up.Conclusion:In this unusual case, the treatment of acromegaly concurred with regression in the endometriotic lesions. Causal or incidental association cannot be inferred from the present case.

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Differential Expression of IGF‐I and IGF‐II in Eutopic and Ectopic Endometria of Women With Endometriosis and in Women Without Endometriosis

Abstract: In endometriosis there is an alteration of mechanisms regulating cell proliferation and differentiation.

Cited by 34 publications

References 8 publications

Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium

Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Effect of octreotide on endometriosis in acromegaly: Case report with review of literature

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