Differential expression of immune factor between patients with chronic prostatitis/chronic pelvic pain syndrome and the healthy volunteers

Wang, Hongzhi; Xiao, Guangan; Xu, Jian; Qin, Shengfei; Luo, Yong; Chen, Guanghua; Lai, H. Henry; Zhou, Tie

doi:10.1007/s11255-017-1763-z

Cited by 13 publications

(12 citation statements)

References 28 publications

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“…Therefore, bacterial infection plays an important role in the initiation, neurologic and organ-specific manifestations CP/CPPS due to the reactions of cell immunity, activation of mast cells and peripheral neurons. 19,20 Our study showed that the prevalence of the UPOINT infection clinical phenotype was no more than 14% of cases after conducting multimodal UPOINT-guided therapy and was mainly related to the presence of resistant strains of microorganisms. The UPOINT infection domain before treatment was observed in 95% and 40% cases for the I and II groups, respectively.…”

Section: Discussionmentioning

confidence: 81%

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study

Krakhotkin¹,

Chernylovskyi

Bakurov

et al. 2019

Therapeutic Advances in Urology

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Background: The aim of this work was to evaluate the influence of UPOINT-guided (Urinary, Psychosocial, Organ-specific, Infection, Neurologic/systemic, Tenderness of skeletal muscles) multimodal therapy in patients with chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) on the dynamic values of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score. Patients and methods: In our study we investigated 110 patients aged 26–68 years with CP/CPPS. We performed digital rectal examination (DRE), pre- and post-massage test (PPMT) urine culture, urine analysis, transrectal ultrasound investigation of prostate, antibiotic susceptibility testing. We divided the patients into the intervention group and the control group which was followed up without any therapy. For the intervention group we offered multimodal therapy based on each predominated positive phenotype. For the urinary phenotype, patients in intervention group received 10 mg alfuzosin. For organ-specific and tenderness domains, the patients of the intervention group received 63 mg Cernilton and 1 g Quercetin. For infection control, the patients of the intervention group received antimicrobial agents according to the results of the post-massage urine culture, antibiotic susceptibility testing and a high level of contamination >105 colony-forming units (CFU)/ml. Microbiological assessment of PPMT urine culture was conducted with aerobic and anaerobic methods of cultivation Results: The 110 patients had an average age of 43.9 ± 11.1 years and a median duration of symptoms of 6.21 ± 1.8 months. Of these, 11 patients did not complete the trial and therefore in quantitative terms, the distribution of patients was as follows: 54 in the intervention group and 45 in the control group. The average total NIH-CPSI score before treatment was 29.8 ± 6.1 in both groups. The mean NIH-CPSI of the pain, urinary, and quality of life (QOL) subscores before treatment was 15.1 ± 3.0, 7.4 ± 1.4 and 8.1 ± 2.1, respectively in both groups. After 6 weeks the PPMT urine culture of patients of the intervention group showed the absence or low-level contamination of microorganisms. After conducting the treatment, the mean total NIH-CPSI score in the intervention and control groups was 13.9 ± 2.8 ( p = 0.025) and 29.8 ± 5.8 ( p = 0.18), respectively. The average NIH-CPSI pain subscore in the intervention and control group after treatment was 6.7 ± 1.4 ( p = 0.018) and 15.1 ± 2.8 ( p = 0.21), respectively. The mean NIH-CPSI urinary subscore after treatment in the intervention and control group was 3.22 ± 1.07 ( p = 0.045) and 7.4 ± 1.2 ( p = 0.15), respectively. The average NIH-CPSI QOL subscore after treatment in the intervention and control group was 3.87 ± 1.28 ( p = 0.015) and 8.1 ± 1.9 ( p = 0.35). After multimodal therapy, the prevalence of different UPOINT-positive domains in the patients of both intervention groups did not exceed 14%. Conclusions: The UPOINT clinical phenotypes significantly changed after multimodal treatment, including antibiotics, phytotherapy and α-blockers in patients with CP/CPPS. This combination of treatment showed a decreasing total NIH-CPSI score and an elevation of QOL in patients.

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Section: Discussionmentioning

confidence: 81%

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study

Krakhotkin¹,

Chernylovskyi

Bakurov

et al. 2019

Therapeutic Advances in Urology

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“…Our team previously investigated expressions of immune markers closely associated with autoimmunity including IgA, IgM, IgG, CD4 + and CD8 + in both CP/CPPS patients and healthy volunteers (41). We found that the CP/CPPS patients had lower serum CD8 + and higher serum IgG levels than healthy volunteers.…”

Section: Discussionmentioning

confidence: 84%

Optimal acupoint and session of acupuncture for patients with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis

et al. 2021

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Background: The study aims to perform a meta-analysis of published trials and evaluate the efficacy of acupuncture on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by symptom score reduction, optimal acupuncture session, and most frequently used acupoints. Methods: A literature search was performed for randomized controlled trials (RCTs) comparing efficacy of acupuncture with sham acupuncture or standard medication on CP/CPPS. The primary outcome was the reduction of National Institute of Health-Chronic Prostatitis Index (NIH-CPSI) total score and its subscales. The optimal acupuncture session to reach its clinical efficacy and most common compatibility rule of acupoints were also evaluated. Results: Ten trials involving 770 participants were included. Meta-analysis showed compared with sham acupuncture, acupuncture yielded significant reduction in NIH-CPSI total score [weighted mean difference

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“…Immune disorders and autoimmunity activation have been hypothesized to contribute to the development of CP/CPPS. 18 The estab- in patients with rheumatoid arthritis, 31,32 Crohn's disease, 33,34 psoriasis 35,36 and atopic dermatitis, 37,38 whereas it is down- when we performed the flow cytometry, we used the PMA to stimulate the T cells that could result in the endocytosis of CD4, causing potential bias. This kind of bias could be removed when the two groups used the same wayy.…”

Section: Discussionmentioning

confidence: 99%

Single‐cell multi‐omics analysis presents the landscape of peripheral blood T‐cell subsets in human chronic prostatitis/chronic pelvic pain syndrome

Zhang

Liu

Chen

et al. 2020

J Cellular Molecular Medi

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Differential expression of immune factor between patients with chronic prostatitis/chronic pelvic pain syndrome and the healthy volunteers

Abstract: Differential levels of IgG and CD8 between CPPS patients and healthy volunteers suggest a contributing role of immune mechanisms to the development of CP/CPPS; and IgG may play an important role in inflammatory CPPS. Clinical Study registration number ACTRN12613000792729.

Cited by 13 publications

References 28 publications

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study

Optimal acupoint and session of acupuncture for patients with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis

Single‐cell multi‐omics analysis presents the landscape of peripheral blood T‐cell subsets in human chronic prostatitis/chronic pelvic pain syndrome

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