Differential Expression of IQGAP1/2 in Hepatocellular Carcinoma and its Relationship with Clinical Outcomes

Xia, Fada; Wang, Zhuolu; Chen, Hongxi; Huang, Yun; Li, Jindong; Wang, Zhiming; Li, Xinying

doi:10.7314/apjcp.2014.15.12.4951

Cited by 26 publications

(34 citation statements)

References 36 publications

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“…Повышение экспрессии IQGAP1 и снижение экспрессии IQGAP2 коррелируют с такими неблаго-приятными клинико-патологическими параметрами, как поздняя стадия опухолевого процесса, больший размер опухоли, неполная инкапсуляция опухоли и низ-кий уровень дифференцировки опухолевой ткани. Комплексное изменение экспрессии IQGAP (повышение IQGAP1 и понижение IQGAP2) является независимым неблагоприятным фактором прогноза выживаемости пациентов и ассоциировано с ранним развитием реци-дива опухоли [50].…”

Section: изменения активности генов Iqgap в канцерогенезеunclassified

“…Гепатоцеллюлярная карцинома Понижение Стимуляция пролиферации, индукция апоптоза [14,28,35,47,50] Карцинома желудка Понижение Стимуляция миграции [48] Опухоли предстательной железы Понижение Подавление пролиферации и инвазии [49] …”

Section: Iqgap2unclassified

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IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

Сковородникова¹,

Chesnokov²,

Будко³

et al. 2017

Usp. mol. onkol

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Section: изменения активности генов Iqgap в канцерогенезеunclassified

Section: Iqgap2unclassified

IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

Сковородникова¹,

Chesnokov²,

Будко³

et al. 2017

Usp. mol. onkol

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“…There are three IQGAPs in human: IQGAP1, IQGAP2, and IQGAP3; the first mentioned is the most well characterized [6,7]. Many studies have been reported the involvement of IQGAPs in human cancers, including gastric [8], pancreatic [9], ovarian [10], esophageal [11], colorectal, and prostate cancer [12]. Interestingly, several studies reported a distinct role between all of three IQGAPs.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, investigating the inhibition mechanism of IQGAP1 or enhancing the expression of IQGAP2 might be necessary to discover their therapeutic potentials. In human, HCC, positive IQGAP1, and negative IQGAP2 expression were linked to tumor progression and might determine clinical outcomes [12]. Moreover, IQGAP3 has been also reported in various cancers.…”

Section: Introductionmentioning

confidence: 99%

In Silico Study of Mirna-Regulated Iq Motif-Containing Gtpase-Activating Protein Family in Liver Cancer

Agustriawan

Sumarpo

Parikesit

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of this paper is to identify the list of microRNA (miRNA) which can regulate the aberrant expression of IQGAP in liver cancer formation. The aberrant expression of IQ motif-containing GTPase-activating protein (IQGAP) family which consists of IQGAP1, IQGAP2, and IQGAP3 has been linked to carcinogenesis in human cancers. The reciprocal expression of IQGAP family in human cancer has been studied to act as oncogenes or tumor suppressor genes. A growing number of studies suggest that upregulated or downregulated expression of IQGAP family triggers cancer development.Methods: A correlation study was performed to construct a pathway to inhibit or activate IQGAP family between miRNAs and IQGAPs. A pre-processing step was conducted to download, filter and process the dataset from TCGA. It yields miRNA and IQGAP gene expression matrix. Then, correlation computation was computed using MATLAB. Moreover, this study linked the results to the MiRTarBase to validate the prediction result with the wet lab experimental result.Results: This study identified significantly inversely correlation in 51 miRNAs-IQGAP1, 169 miRNAs-IQGAP2, and 33 miRNAs-IQGAP3, respectively, which may potentially play a role in a liver cancer formation. Some of the results also can be found in miRTarBase. It supports the precision of those miRNA and IQGAP interaction between dry lab and wet lab study. IQGAP1 and IQGAP2 mostly has been identified as an oncogene in cancer but IQGAP2 has been discovered as tumor suppressor gene. The list of miRNA in the result of this study can become a potential therapy to target the aberrant expression of IQGAP family.Conclusion: miRNA function is known as an oncogene or tumor suppressor gene in cancer development. Therefore, it can be one of the important molecular biology which may target the aberrant expression of IQGAP in liver cancer.

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“…1); however, deregulation of IQGAPs might promote the development of various diseases [11]. In addition, there is a mounting evidence, suggesting an involvement of IQGAPs in human carcinogenesis in various types of cancer including ovarian [18], gastric [19], esophageal [20], liver [21][22][23][24][25], colorectal [26], breast [27], and prostate cancer [28]. Several studies have implicated that the presence of IQGAPs in pancreatic cancer is evident and might be correlated with tumorigenesis [29][30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Biomarker Potential of Iq-Domain Gtpase-Activating Proteins Family Protein in Pancreatic Cancer: A Mini Review

Sumarpo

Sahamastuti

Tjugianto

et al. 2018

Asian J Pharm Clin Res

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Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.Methods: In this review, relevant studies were obtained by assessing the PubMed database using the combination of words that included “IQGAP” and “pancreatic cancer”.Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.

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Differential Expression of IQGAP1/2 in Hepatocellular Carcinoma and its Relationship with Clinical Outcomes

Cited by 26 publications

References 36 publications

IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

In Silico Study of Mirna-Regulated Iq Motif-Containing Gtpase-Activating Protein Family in Liver Cancer

Biomarker Potential of Iq-Domain Gtpase-Activating Proteins Family Protein in Pancreatic Cancer: A Mini Review

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