Differential expression of periostin in the nasal polyp may represent distinct histological features of chronic rhinosinusitis

Shiono, Osamu; Sakuma, Yasunori; Komatsu, Masanori; Hirama, Mariko; Yamashita, Yukiko; Ishitoya, Junichi

doi:10.1016/j.anl.2014.09.003

Cited by 21 publications

(32 citation statements)

References 23 publications

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“…It is characterized by progression of an in ammatory mass into the nasal cavity, leading to complications such as nasal obstruction, reduce sense of smell, headache, and consequently reduce quality of life [2,3,4]. NP as a multifactorial disease is usually associated with diseases such as asthma and other respiratory diseases, including cystic brosis and aspirin sensitivity [3,5]. It is reported that, the prevalence of NP in various populations is 1-4% [6].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Faghani¹,

Pourgholamali²,

Ansar³

et al. 2020

Preprint

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Background: The Sambucus Ebulus (ES) L. has an anti-inflammatory role by reducing the expression of pro-inflammatory genes and free radicals. The aim of this study was to evaluate the anti-inflammatory effect of hydroalcoholic extract of SE fruits on eosinophilic nasal polyposis (NP) in Vitro.Method: The chemical composition of SE fruits extract was determined by gas chromatography-mass spectrometry. Polyp Samples were collected from 40 patients and were cut into four pieces (control and case groups). Tissue fragments were treated with 0 (control), 50, 315 and 1000µg/ml of SE FRUIT extract in a culture medium for 24 hours. Apoptosis was detected by TUNEL reaction reagent. Real time-PCR was employed to evaluate the expression of Bax and Bad genes. ELISA was used for assay of IL-5 and GM-CSF.Results: Our findings showed SE fruits extract increased apoptosis in nasal polyp tissues compared to the control group (P<0.001). Also, GM-CSF level in the experimental groups was significantly lower than that in the control group (P<0.001). In contrast, the level of IL-5 was not significantly different in the treatment and control groups (P>0.05). Bax and Bad expression showed a significant increase in the experimental groups compared to the control group (P<0.001).Conclusion: Our findings showed that SE fruits hydroalcoholic extract ameliorates NP trough elevation of apoptosis and reduction of inflammatory markers. Our experimental data revealed that SE fruits extract plays an important role in the treatment of nasal polyp through inducing apoptosis and reducing the survival of inflammatory cells.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Faghani¹,

Pourgholamali²,

Ansar³

et al. 2020

Preprint

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“…The murine model of asthma treated with HDMs has been extensively studied. In this model, Postn +/+ mice have exhibited increased airway responsiveness [ 67 ], as well as elevated levels of periostin expression in the airways, not only in the peribronchial inflammatory cells, but in the fluid lining of the airways as well [ 59 ]. Postn +/+ and wild-type mice have also exhibited significantly elevated levels of allergic airway inflammation, with an increased number of eosinophils present compared with periostin-deficient mice [ 5 , 12 , 26 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Periostin: its role in asthma and its potential as a diagnostic or therapeutic target

et al. 2015

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Accumulating evidence shows that periostin, a matricellular protein, is involved in many fundamental biological processes such as cell proliferation, cell invasion, and angiogenesis. Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating a diverse set of cancer cell activities that contribute to tumorigenesis, cancer progression, and metastasis. Periostin has also been shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype, and increased expression of inflammatory mediators. In an in vivo model, bronchoalveolar lavage (BAL) fluid obtained from ovalbumin-challenged mice was found to contain significantly higher levels of periostin compared to BAL samples from control mice. To date, the molecular mechanisms involving periostin in relation to asthma in humans have not been fully elucidated. This review will focus on what is known about periostin and its role in the pathophysiological mechanisms that mediate asthma in order to evaluate the potential for periostin to serve as a biomarker and therapeutic target for the detection and treatment of asthma, respectively.

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“…One recent approach to this solution is the development of biosignatures that are both sensitive and specific to CRSwNP. Several studies have described altered protein expression in nasal polyps relative to control mucosa . Interestingly, derangements in coagulation pathway proteins have featured prominently in many of these reports .…”

mentioning

confidence: 99%

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps

Müller

Nocera

Dillon

et al. 2018

Int Forum Allergy Rhinol

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Our proteomic analysis confirmed that the coagulation pathway is highly significantly deranged within nasal polyp tissue. The correlation between tissue- and mucus-derived exosomal fibrinolysis and coagulation protein alterations were strong, inverse, and highly significant. This lends further support to the emerging concept of exosomal proteomic analysis as a method to study chronic sinonasal inflammation.

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Differential expression of periostin in the nasal polyp may represent distinct histological features of chronic rhinosinusitis

Cited by 21 publications

References 23 publications

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

WITHDRAWN: Sambucus Ebulus Fruits Extract Ameliorates Eosinophilic Nasal Polyposis: An in vitro Study

Periostin: its role in asthma and its potential as a diagnostic or therapeutic target

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps

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