Differential expression of proteoglycans at central and peripheral nodes of Ranvier

Melendez‐Vasquez, Carmen V.; Carey, David J.; Zanazzi, George; Reizes, Ofer; Maurel, Patrice; Salzer, James L.

doi:10.1002/glia.20245

Cited by 55 publications

(48 citation statements)

References 58 publications

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“…Matrices that contain mainly versican V2 and some brevican are most prevalent in the white matter surrounding the myelinated Wbers of all calibers (Ogawa et al 2001;Schmalfeldt et al 2000). Particularly dense accumulation of versican V2, HAPLN2/Bral1, Tn-R and phosphacan appear as ring-like structures around the CNS nodes of Ranvier (Dours- Zimmermann et al unpublished;Melendez-Vasquez et al 2005;Oohashi et al 2002;Pesheva et al 1989;Xiao et al 1997). Origins of the Tn-R and versican V2 deposits in the white matter are primarily oligodendrocytes and their precursors Pesheva et al 1989;Schmalfeldt et al 2000), while HAPLN2/Bral1 expression has been attributed to neurons (Oohashi et al 2002) or oligodendrocytes .…”

Section: Mature Matrix Typementioning

confidence: 99%

Extracellular matrix of the central nervous system: from neglect to challenge

Zimmermann

Dours-Zimmermann

2008

Histochem Cell Biol

406

340

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(aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated fiber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have significantly contributed to the increased awareness of this long time neglected structure. Abstract The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated Wber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have signiWcantly contributed to the increased awareness of this long time neglected structure.

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Section: Mature Matrix Typementioning

confidence: 99%

Extracellular matrix of the central nervous system: from neglect to challenge

Zimmermann

Dours-Zimmermann

2008

Histochem Cell Biol

406

340

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“…In peripheral nerve tissue Type-V collagen is present in basal laminae of myelinated Schwann cell-axon units and in the surrounding ECM (Chernousov et al, 2006). In mature myelinated Schwann cell-axon units Type-V collagen localization is concentrated in the perinodal ECM (Melendez-Vasquez et al, 2005).…”

Section: Type-v Collagenmentioning

confidence: 99%

Regulation of Schwann cell function by the extracellular matrix

Chernousov

Chen

et al. 2008

Glia

Self Cite

171

138

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Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development. V V C

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“…In the adult CNS, versican V2 and HAPLN2/Bral1 are the prominent components of the white matter ECM and particularly accumulate at the nodes of Ranvier (Schmalfeldt et al, 1998(Schmalfeldt et al, , 2000Oohashi et al, 2002;Melendez-Vasquez et al, 2005). Conversely, aggrecan, HAPLN4/Bral2, and neurocan associate with perineuronal nets (Brückner et al, 2000;Bekku et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS

Dours-Zimmermann¹,

Maurer²,

Rauch³

et al. 2009

Journal of Neuroscience

105

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The CNS-restricted versican splice-variant V2 is a large chondroitin sulfate proteoglycan incorporated in the extracellular matrix surrounding myelinated fibers and particularly accumulating at nodes of Ranvier. In vitro, it is a potent inhibitor of axonal growth and therefore considered to participate in the reduction of structural plasticity connected to myelination. To study the role of versican V2 during postnatal development, we designed a novel isoform-specific gene inactivation approach circumventing early embryonic lethality of the complete knock-out and preventing compensation by the remaining versican splice variants. These mice are viable and fertile; however, they display major molecular alterations at the nodes of Ranvier. While the clustering of nodal sodium channels and paranodal structures appear in versican V2-deficient mice unaffected, the formation of the extracellular matrix surrounding the nodes is largely impaired. The conjoint loss of tenascin-R and phosphacan from the perinodal matrix provide strong evidence that versican V2, possibly controlled by a nodal receptor, organizes the extracellular matrix assembly in vivo.

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Differential expression of proteoglycans at central and peripheral nodes of Ranvier

Cited by 55 publications

References 58 publications

Extracellular matrix of the central nervous system: from neglect to challenge

Extracellular matrix of the central nervous system: from neglect to challenge

Regulation of Schwann cell function by the extracellular matrix

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS

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