Differential expression of S100 calcium‐binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas

Pelc, Patricia; Vanmuylder, Nathalie; Lefranc, Florence; Heizmann, Claus W.; Hassid, Sergio; Salmon, Isabelle; Kiss, Róbert; Louryan, Stéphane; Decaestecker, Christine

doi:10.1046/j.1365-2559.2003.01588.x

Cited by 18 publications

(18 citation statements)

References 31 publications

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“…Normally, the S100A5 protein is expressed in restricted areas of wildtype mouse brain . Expression of S100A5 was recently detected in epidermoid lesions and in the human kidney (Teratani et al, 2002;Pelc et al, 2003).…”

Section: Rt-pcr Analysismentioning

confidence: 98%

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene

et al. 2004

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Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca 2 þ -binding proteins. A mouse strain with a germ-line inactivation of the S100A4 gene was generated. The mice were viable and did not display developmental abnormalities in the postnatal period. However, an abnormal sex ratio was observed in the litters with the S100A4À/À genotype, raising the possibility of a certain level of embryonic lethality in this strain. In all, 10% of 10-14-month-old S100A4-null animals developed tumors. This is a characteristic feature of mouse strains with inactivated tumor suppressor genes. Spontaneous tumors of S100A4À/À mice were p53 positive. Recently, we have shown that S100A4 interacts with p53 tumor suppressor protein and induces apoptosis. We proposed that impairment of this interaction could affect the apoptosis-promoting function of p53 that is involved in its tumor suppressor activity. The frequency of apoptosis in the spleen of S100A4À/À animals after whole-body c-irradiation was reduced compared to the wild-type animals. The same was true for the transcriptional activation of the p53 target genes -waf/p21/cip1 and bax. Taken together, these observations indicate that spontaneous tumors in S100A4À/À mice are a result of functional destabilization of p53 tumor suppressor gene.

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Section: Rt-pcr Analysismentioning

confidence: 98%

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene

et al. 2004

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“…Previous studies reported that S100A6 participates in cytoskeletal rearrangement and regulates cell cycle, intracellular calcium homeostasis and signaling, and ion transport [5][6][7]. Recent research has revealed that S100A6 is overexpressed in many cancer types, including melanoma [8], colorectal adenocarcinomas [9][10][11], gastric cancer [12], pancreatic ductal adenocarcinoma [13,14], astrocytoma [15], papillary thyroid carcinoma [16], choleteatoma [17], and osteosarcoma [18]. Increased S100A6 expression is also associated with the progression of tumors and could be used to predict the outcome of patients, such as pulmonary adenocarcinoma [19], pancreatic cancer [20], and gastric cancer [21].…”

Section: Introductionmentioning

confidence: 99%

High-Level S100A6 Promotes Metastasis and Predicts the Outcome of T1–T2 Stage in Clear Cell Renal Cell Carcinoma

Lyu

et al. 2014

Cell Biochem Biophys

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S100A6 (calcyclin), functions in cell cycle progression and differentiation, has been reported to promote the tumorigenesis and malignancy of many types of cancers. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC, lacking both promising prognostic markers and effective therapeutic targets. In our previous study, we have found the elevated S100A6 in the ccRCC tumor tissues, and the differentially expressed genes determined by microarray analysis were found to be strongly related to tumor metastasis after S100A6 knockdown and overexpression in the ccRCC cell line 786-O. The mRNA expression of S100A6 detected by RT-PCR in 6 cell lines and 174 tumor tissues, including 58 metastatic ccRCC and 116 clinicopathological features paired non-metastatic ccRCC (1:2), indicated S100A6 was elevated in the metastatic cells and tumor tissues. The protein expression was consistent with mRNA expression. The biological function of S100A6 in promoting metastasis was determined through overexpression and knockdown of S100A6 in the ccRCC cell lines 786-O, caki-1, and ACHN. In the scratch wound migration assay as well as migration and invasion assays, S100A6 knockdown significantly suppressed the migratory and invasive abilities of tumor cells, whereas overexpression enhanced the malignancy. Further research with the follow-up data of 129 ccRCC patients were analyzed by the Cox regression and survival analysis. The expression of S100A6 was up-regulated in metastatic ccRCC cells. In the metastatic tumor tissues, the expression of S100A6 was also higher than in the non-metastatic tissues. High S100A6 expression might be crucial to promote metastasis in ccRCC by enhancing the ability of tumor cells migration and invasion. In addition, the quantitative mRNA expression of S100A6 in the tumor tissues was an independent risk factor and might be used as a prognostic marker for the metastatic risk of the localized T1-T2 stage ccRCC.

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“…In the cholesteatomas, the reactivity was strongest in the upper epithelial layers. The basal membrane was less positive (6). In our collective, the epithelial matrix of the EACC showed strong reactivity throughout all the layers.…”

Section: Discussionmentioning

confidence: 53%

“…They concluded that in contrast to S100B, the expression of S100A1, S100A2, S100A4 and S100A5 are often present in epidermoid cysts, branchial cysts, craniopharyngiomas and middle ear cholesteatomas. S100A3 and S100A6 (and, to a lesser extent, S100A5) were most dif-ferentially expressed across the different histopathological groups analysed (6). In the field of Otolaryngology, the external auditory canal cholesteatoma (EACC) is a very rare pathological entity (7).…”

Section: Introductionmentioning

confidence: 99%

The role of S100A1 in external auditory canal cholesteatoma

Naim

Hörmann²

2006

Oncol Rep

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Abstract. S100 proteins were reported to be involved in different biological activities such as transduction of intracellular calcium signalling. It has been reported that each member of the S100 protein family exhibits a distinct tissue-specific pattern of expression. Furthermore, altered S100 protein expression and function correlate with many diseases. The expression of S100A1 was reported to be increased in different tissue with hyperplasia. The external auditory canal cholesteatoma (EACC) is a benign hyperplasia of the auditory meatal skin. However, without treatment, EACC destroys adjacent tissue. Seventeen EACC specimens were collected and investigated immunohistochemically against S100A1. Normal auditory meatal skin served as control. In the EACC, S100A1 showed a more homogeneous staining pattern, positively expressed throughout the epithelial layers. The keratin debris showed no detectable expression of S100A1. In the auditory meatal skin (control), S100A1 was only expressed in the basal layer of the epithelium. We showed that there are different staining patterns in normal auditory meatal skin, middle ear cholesteatoma and external auditory canal cholesteatomas. The immunoreactivity increased with the stage of the disease. Contrary to that reported previously in the middle ear cholesteatomas, the reactivity was strongest in the upper epithelial layers. In our collective, the epithelial matrix of the EACC showed strong reactivity throughout all the layers. Surprisingly, there is no study regarding the connection between growth factors and S100A1. In previous experiments we showed significant increase of growth factors in EACC. This correlates with our new data concerning S100A1. This is the first study to show the different reactivity pattern of S100A1 in the external auditory canal cholesteatoma.

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Differential expression of S100 calcium‐binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas

Cited by 18 publications

References 31 publications

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene

High-Level S100A6 Promotes Metastasis and Predicts the Outcome of T1–T2 Stage in Clear Cell Renal Cell Carcinoma

The role of S100A1 in external auditory canal cholesteatoma

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