Differential Expression of the hTERT Gene in Umbilical Cord-Derived Mesenchymal Stem Cells Cocultured with B Cell Precursor Leukemia Cell Microparticles or CD41+/CD61+ Platelet Microparticles

Yari, Fatemeh; Ashoub, Muhammad Hossein; Amirizadeh, Naser; Nikougoftar, Mahin; valandani, Hajar Mardani; Khalilabadi, Roohollah Mirzaee

doi:10.1007/s10528-023-10565-9

Biochem Genet

2023

DOI: 10.1007/s10528-023-10565-9

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Differential Expression of the hTERT Gene in Umbilical Cord-Derived Mesenchymal Stem Cells Cocultured with B Cell Precursor Leukemia Cell Microparticles or CD41+/CD61+ Platelet Microparticles

Fatemeh Yari,

Muhammad Hossein Ashoub,

Naser Amirizadeh

et al.

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Cited by 2 publications

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Comparative RNA sequencing analysis of three Capripoxvirus infections in an immortalized hTERT-bOEC cell model

Zhang,

Wang,

Chen

et al. 2025

Virology

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Comparative RNA sequencing analysis of three Capripoxvirus infections in an immortalized hTERT-bOEC cell model

Zhang,

Wang,

Chen

et al. 2025

Virology

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Magnetic and pH sensitive nanocomposite microspheres for controlled temozolomide delivery in glioblastoma cells

Ahmadi,

Ashoub,

Heydarian

et al. 2024

Sci Rep

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Controlled drug delivery systems have been intensively researched for cancer treatment to increase precision targeting and therapeutic efficacy. In this context, novel magnetic-/pH-sensitive graphene oxide/chitosan/iron oxide magnetic nanocomposite microspheres were synthesized. Fe 3 O 4 (IO) nanoparticles (NPs) were synthesized via the green synthesis method in the presence of Salvia officinalis extract. The graphene oxide (GO) NPs were prepared using the Staudenmaier method, and synthesized materials were characterized. Chitosan (CS) was used to prepare microspheres. GO/CS/IO microspheres were investigated as prospective vehicles for controlled temozolomide delivery in the presence and absence of an external magnetic field. The release percentage of temozolomide molecules in the presence of 100 Hz reached a maximum in 90 min. This is approximately twice the amount of drug release in the absence of a magnetic field and more than that in the presence of a 50 Hz magnetic field. Also, the highest degree of swelling was observed at a pH of 4.5, higher than at a pH of 7.4. Also, the MTT assay results indicated the cytotoxicity of the synthesized microspheres for glioblastoma cells; notably, a significant difference was observed between the groups exposed to the magnetic field and those not, with exposure to the magnetic field further reducing survival. These results indicated that the magnetic microspheres potentially apply to controlled drug delivery systems.

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Differential Expression of the hTERT Gene in Umbilical Cord-Derived Mesenchymal Stem Cells Cocultured with B Cell Precursor Leukemia Cell Microparticles or CD41+/CD61+ Platelet Microparticles

Cited by 2 publications

References 44 publications

Comparative RNA sequencing analysis of three Capripoxvirus infections in an immortalized hTERT-bOEC cell model

Comparative RNA sequencing analysis of three Capripoxvirus infections in an immortalized hTERT-bOEC cell model

Magnetic and pH sensitive nanocomposite microspheres for controlled temozolomide delivery in glioblastoma cells

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