Differential expression of Wnt genes, β-catenin and E-cadherin in human brain tumors

Howng, Shen-Long; Wu, Chia-Hung; Cheng, Tsung Chieh; Sy, Wei-Di; Lin, Pi-Chu; Wang, Chihuei; Hong, Yi‐Ren

doi:10.1016/s0304-3835(02)00085-x

Cited by 78 publications

(75 citation statements)

References 20 publications

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“…Additionally, it was demonstrated during our study that the mRNA and protein expressions of Wnt1, β‐catenin, TCF‐4 and E‐cadherin were increased in other groups as compared with the model group. β‐catenin/TCF‐4 mutations regulating Wnt signalling and E‐cadherin gene have been linked with the development of brain oncogenesis 27. Wnt1 has been proven to protect against neuronal injury, protein of which significantly increases neuronal cell survival 28.…”

Section: Discussionmentioning

confidence: 99%

Retracted: MicroRNA‐140‐5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β‐catenin signalling pathway

Han

Wen

Wang

et al. 2018

J Cellular Molecular Medi

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Hypoxia–ischaemia (HI) remains a major cause of foetal brain damage presented a scarcity of effective therapeutic approaches. Dexmedetomidine (DEX) and microRNA‐140‐5p (miR‐140‐5p) have been highlighted due to its potentially significant role in the treatment of cerebral ischaemia. This study was to investigate the role by which miR‐140‐5p provides cerebral protection using DEX to treat hypoxic–ischaemic brain damage (HIBD) in neonatal rats via the Wnt/β‐catenin signalling pathway. The HIBD rat models were established and allocated into various groups with different treatment plans, and eight SD rats into sham group. The learning and memory ability of the rats was assessed. Apoptosis and pathological changes in the hippocampus CA1 region and expressions of the related genes of the Wnt/β‐catenin signalling pathway as well as the genes responsible of apoptosis were detected. Compared with the sham group, the parameters of weight, length growth, weight ratio between hemispheres, the rate of reaching standard, as well as Bcl‐2 expressions, were all increased. Furthermore, observations of increased levels of cerebral infarction volume, total mortality rate, response times, total response duration, expressions of Wnt1, β‐catenin, TCF‐4, E‐cadherin, apoptosis rate of neurons, and Bax expression were elevated. Following DEX treatment, the symptoms exhibited by HIBD rats were ameliorated. miR‐140‐5p and si‐Wnt1 were noted to attenuate the progression of HIBD. Our study demonstrates that miR‐140‐5p promotes the cerebral protective effects of DEX against HIBD in neonatal rats by targeting the Wnt1 gene through via the negative regulation of the Wnt/β‐catenin signalling pathway.

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Section: Discussionmentioning

confidence: 99%

Retracted: MicroRNA‐140‐5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β‐catenin signalling pathway

Han

Wen

Wang

et al. 2018

J Cellular Molecular Medi

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“…The expression of β-catenin was further confirmed by IHC. The present data support the opinion that the Wnt canonical signaling pathway is activated in NFPAs, and is consistent with previous studies (35). However, the present western blotting results of total β-catenin protein expression indicated that there was no significant difference between normal control and non-aggressive NFPA groups, or between non-aggressive and aggressive NFPA groups.…”

Section: Discussionsupporting

confidence: 93%

Low expression of secreted frizzled-related protein 2 and nuclear accumulation of β-catenin in aggressive nonfunctioning pituitary adenoma

Bai

Hong

et al. 2016

Oncology Letters

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Abstract. The identification of a specific molecular marker for aggressiveness of nonfunctioning pituitary adenomas (NFPAs) is urgently required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, low expression of secreted frizzled-related protein 2 (sFRP2) in NFPAs was demonstrated by reverse transcription-quantitative polymerase chain reaction, western blot and immunohistochemical analyses. The results confirmed an abnormal accumulation of free β-catenin in the nuclei of NFPAs, which is the core step for the activation of the Wnt canonical signaling pathway. Furthermore, cyclin D1 and c-Myc, the downstream proteins of the Wnt canonical signaling pathway, were overexpressed in aggressive NFPAs. These findings demonstrated the activation of the Wnt canonical signaling pathway in aggressive NFPAs. In addition, sFRP2 expression was observed to be inversely correlated to the aggressiveness of NFPAs. Therefore, sFRP2 may act as a tumor suppressor through modulation of the cellular cytosolic pool of β-catenin in NFPAs. Furthermore, the expression of sFRP2 may serve as a biomarker for NFPAs aggressiveness and prognosis.

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“…It has been well documented that wnt genes, together with other components of wnt signaling pathway, are implicated in tumorigenesis and lately also in brain tumorigenesis (5,10). Our interest in genes of the wnt pathway stemmed principally from several findings.…”

Section: Introductionmentioning

confidence: 99%

Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors

Nikuševa-Martić

Beroš

Pećina‐Šlaus

et al. 2007

Pathology - Research and Practice

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Differential expression of Wnt genes, β-catenin and E-cadherin in human brain tumors

Cited by 78 publications

References 20 publications

Retracted: MicroRNA‐140‐5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β‐catenin signalling pathway

Retracted: MicroRNA‐140‐5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β‐catenin signalling pathway

Low expression of secreted frizzled-related protein 2 and nuclear accumulation of β-catenin in aggressive nonfunctioning pituitary adenoma

Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors

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