2020
DOI: 10.21203/rs.3.rs-41297/v1
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Differential gene expression in skin RNA of horses affected with degenerative suspensory ligament desmitis

Abstract: Background Equine Degenerative Suspensory Desmitis (DSLD) is a systemic connective tissue disorder first identified in Peruvian Paso horses, but afflicting other horse breeds as well. Inappropriate accumulation of proteoglycans in connective tissues, most prominently in tendons and ligaments leads to lameness and pain. It is largely unknown what drives the overproduction of proteoglycans, but our previous data suggest involvement of bone morphogenetic protein 2 (BMP2), a member of the transforming growth fact… Show more

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