Differential gene expression of Wharton’s jelly-derived mesenchymal cells mediated by graphene oxide in basal and osteo-induced media

Hiew, Vun Vun; Teoh, Peik Lin

doi:10.1007/s11033-024-09324-9

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The Role Of Dnmts In Osteogenic Differentiation Of Mscs1

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2024

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“…Wharton’s jelly derived MSCs (WJ-MSCs) obtained from human umbilical cord were treated with graphene oxide (GO) and were found to exhibit a decrease in DNMT3B expression after undergoing osteogenic induction ( Hiew and Teoh, 2024 ). Interestingly, RNA interference was used to inhibit endogenous DNMT3B expression in human umbilical cord mesenchymal stem cells (hUMSCs), which resulted in impaired osteogenic differentiation of hUMSCs ( Zhu et al, 2014 ).…”

Section: The Role Of Dnmts In Osteogenic Differentiation Of Mscsmentioning

confidence: 99%

Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

Lai,

Shu,

Song

et al. 2024

Front. Genet.

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Mesenchymal stem cells (MSCs) have promising potential for bone tissue engineering in bone healing and regeneration. They are regarded as such due to their capacity for self-renewal, multiple differentiation, and their ability to modulate the immune response. However, changes in the molecular pathways and transcription factors of MSCs in osteogenesis can lead to bone defects and metabolic bone diseases. DNA methylation is an epigenetic process that plays an important role in the osteogenic differentiation of MSCs by regulating gene expression. An increasing number of studies have demonstrated the significance of DNA methyltransferases (DNMTs), Ten-eleven translocation family proteins (TETs), and MSCs signaling pathways about osteogenic differentiation in MSCs. This review focuses on the progress of research in these areas.

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Section: The Role Of Dnmts In Osteogenic Differentiation Of Mscsmentioning

confidence: 99%