Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

Sheth, Sachiv; Li, Xinmin; Binder, Scott W.; Dry, Sarah M.

doi:10.1038/modpathol.2010.203

Cited by 81 publications

(46 citation statements)

References 84 publications

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“…59 Finally, a recent study compared the genetic profiles of nerve sheath myxoma, cellular neurothekeoma, schwannoma, and cellular dermatofibroma, and it was found that nerve sheath myxoma showed a genetic profile similar to that of schwannoma, whereas cellular neurothekeoma showed a similar profile to that of cellular dermatofibroma; the authors concluded that nerve sheath myxoma was a schwannomatous tumor, whereas cellular neurothekeoma was probably a fibrohistiocytic tumor. 60 BCPHTPCN shares some histopathologic and immunohistochemical features with perineurioma and cellular neurothekeoma. From a histopathologic point of view, these 3 neoplasms show a nested and plexiform pattern, with the neoplastic aggregates composed of plump spindle or ovoid cells arranged in a whorled manner and embedded in a myxoid stroma.…”

Section: Discussionmentioning

confidence: 97%

A Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma

Requena¹,

Sitthinamsuwan²,

Fried³

et al. 2013

American Journal of Surgical Pathology

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There are several recent reports describing hybrid peripheral nerve sheath tumors showing a biphasic component of neoplastic cells. These combinations include a mixture of neurofibroma and schwannoma, schwannoma and perineurioma, neurofibroma and perineurioma, and perineurioma and granular cell tumor. A case of a triphasic combination of neurofibroma, schwannoma, and perineurioma has also been described. We describe the clinicopathologic and immunohistochemical characteristics of 9 cases of a benign cutaneous plexiform nerve sheath tumor located on the lips and exhibiting hybrid features of perineurioma and cellular neurothekeoma. Clinically, lesions were solitary dome-shaped papules located on the lips. Histopathologically, the neoplasms consisted of well-circumscribed but uncapsulated dermal nodules with a plexiform pattern. They were composed of nests or rounded aggregations of neoplastic cells embedded in a slightly myxoid stroma. Within the aggregates, cells were distributed in a storiform and lamellar pattern. Immunohistochemically, most neoplastic cells expressed strong immunoreactivity for S100A6, MiTF, NKI/C3, PGP9.5, EMA, and NSE, whereas variable, focal, and weaker positivity for CD34, claudin-1, and Glut-1 was seen in some cases. On the basis of these findings, we believe that this neoplasm is a distinctive benign cutaneous plexiform nerve sheath tumor with histopathologic and immunohistochemical hybrid features of perineurioma and cellular neurothekeoma.

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Section: Discussionmentioning

confidence: 97%

A Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma

Requena¹,

Sitthinamsuwan²,

Fried³

et al. 2013

American Journal of Surgical Pathology

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“…Although there are histologic differences, the two entities show molecular overlap with upregulation of the same genes involved in extracellular matrix growth and remodeling, including dermatopontin (DPT), a disintegrin and metalloproteinase domain 12 (ADAM12), matrix metalloproteinase 1 (MMP1), and periston osteoblast-specific factor (POSTN). 34 This underscores the classification of cellular neurothekeoma as a so-called fibrohistiocytic tumor.…”

Section: Discussionmentioning

confidence: 99%

Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features

Stratton

Billings

2014

Modern Pathology

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Cellular neurothekeoma is a frequent source of diagnostic difficulty. In order to gain more insight into the range of histologic features of cellular neurothekeoma, we examined all cases from our institution, with a focus on describing atypical histologic features. Cases with sufficient histologic material for evaluation were retrieved. Cases were analyzed for demographics, growth pattern, myxoid stroma, cytologic atypia, mitotic rate, perineural invasion, and other histologic features. The 37 patients (16 M; 21 F) had a mean age of 31.0 years (range: 4-89). Tumors involved the head and neck (n ¼ 16), arms (n ¼ 11), trunk and shoulders (n ¼ 8), and foot (n ¼ 2). All cases had at least focal nesting of epithelioid to spindled tumors cells characteristic of cellular neurothekeoma. In many, alternate growth patterns were present and represented the dominant pattern in some. These patterns included fascicular (n ¼ 9), sheet-like (n ¼ 6), and corded (n ¼ 4). Myxoid stroma was present in 14 and was prominent in 5. Cytologic atypia was present in 19 patients, with 3 having severe atypia. Mean mitotic rate was 2.0/mm 2 (range 0-10 per mm 2 ). Neurotropism was seen in four cases. Other unusual features included collagen trapping, giant cells, hemorrhage, lymphocytic cuffing, chondroid stroma, and cellular vacuolization. Cellular neurothekeoma has a wider range of features than is commonly recognized. The presence of nests of epithelioid tumor cells with characteristic cytologic features, no matter how focal, is a clue to the diagnosis. Keywords: atypical cellular neurothekeoma; cellular neurothekeoma; immunohistochemistry Cellular neurothekeoma, formerly considered a nerve sheath tumor, is a dermal neoplasm of presumed fibrohistiocytic lineage. 1-3 They typically occur on the head, neck, and upper body of young adults, with a slight female predominance. [2][3][4] The classic histology of cellular neurothekeoma is of a dermal-based lesion with a lobular growth pattern that forms nests with a swirling to slightly fascicular growth pattern. The tumor cells are epithelioid to spindled with abundant pale eosinophilic cytoplasm, oval nuclei with pinpoint nucleoli. Although most cellular neurothekeomas display these characteristic histologic features, atypical features have been described, including prominent myxoid stroma, cytologic atypia, infiltrative growth, vascular invasion, perineural invasion, fascicular and plexiform growth patterns, and dense hyalinized stroma. 3-9 When atypical features are present, the diagnosis of cellular neurothekeoma can be challenging. For this reason, cellular neurothekeoma with atypical features is a relatively frequent source of referral to our consultation practice. In order to gain more insight into the range of histologic features of cellular neurothekeoma, we examined a large series from our practice with a focus on describing unusual features. Materials and methodsWe retrieved all cases of cellular neurothekeoma from 1980 to 2012 with sufficient histologic material. We recorded the demo...

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“…In fact, NSM and neurothekeoma were considered a single phenomenon in the past, while after the advent of immunohistochemistry, they were separately defined. These tumors have different gene expression profiles (8), and neurothekeoma has been suggested to belong to the category of fibrohistiocytic tumors.…”

Section: Discussionmentioning

confidence: 99%

Finger Nerve Sheath Myxoma: A Rare Case Report

Shooshtarizadeh

Mohammadpour

2017

Shafa Ortho J

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Introduction: Nerve sheath myxoma (NSM) is a rare benign neoplasm of nerve sheath origin with Schwann cell differentiation. NSM and neurothekeoma were considered one single phenomenon in the past. Case Presentation: A 28-year-old woman presented to our hospital clinic with pain and a fixed firm mass in the proximal phalanx of the right second finger. Excisional biopsy was performed and histological examination revealed NSM. Conclusions: Based on the findings, NSM should be considered in the differential diagnosis of firm and tender masses in the upper extremities of young adults.

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Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis

Cited by 81 publications

References 84 publications

A Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma

A Benign Cutaneous Plexiform Hybrid Tumor of Perineurioma and Cellular Neurothekeoma

Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features

Finger Nerve Sheath Myxoma: A Rare Case Report

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