Differential Gene Expression Profiling in Bed Bug (Cimex Lectularius L.) Fed on Ibuprofen and Caffeine in Reconstituted Human Blood

Narain, Ralph B.; Kamble, Haichuan Wang Shripat T

doi:10.4172/2161-0983.1000160

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Toxicants including fipronil, clothianidin, abamectin, boric acid (122,123), spinosad, and fluralaner (116), added to the blood and delivered via an artificial membrane feeding system, were lethal to C. lectularius. RNA interference (RNAi) can downregulate gene expression, and experiments using RNAi on C. lectularius led to reduced adult female fecundity (60,95) and impaired egg production and viability (12). Bed bug symbionts provide essential nutrients to the insect, such as vitamin B.…”

Section: Future Managementmentioning

confidence: 99%

Historical and Contemporary Control Options Against Bed Bugs,Cimexspp.

Doggett

Lee

2023

Annu. Rev. Entomol.

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Bed bugs (Hemiptera: Cimicidae) are an important group of obligate hematophagous urban insect pests. The global resurgence of bed bugs, involving the common bed bug, Cimex lectularius L., and the tropical bed bug, Cimex hemipterus (F.), over the past two decades is believed to be primarily due to the development of insecticide resistance, along with global travel and poor pest management, which have contributed to their spread. This review examines and synthesizes the literature on bed bug origins and their global spread and the literature on historical and contemporary control options. This includes bed bug prevention, detection and monitoring, nonchemical and chemical control methodologies (and their limitations), and potential future control options. Future research needs are highlighted, especially the factors behind the modern resurgence, the necessity of identifying differences between the two bed bug species relevant to control, and the need to improve insecticide test protocols and management strategies. Expected final online publication date for the Annual Review of Entomology, Volume 68 is January 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Future Managementmentioning

confidence: 99%

Historical and Contemporary Control Options Against Bed Bugs,Cimexspp.

Doggett

Lee

2023

Annu. Rev. Entomol.

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A screen of pharmaceutical drugs for their ability to cause short-term morbidity and mortality in the common bed bug, Cimex lectularius L.

Sheele

Ridge

et al. 2017

Parasitol Res

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The common bed bug, Cimex lectularius L., is a hematophagous ectoparasite that preferentially feeds on humans. Pharmaceuticals present in a person's blood may adversely affect C. lectularius when it feeds. We fed >10,000 C. lectularius on blood samples containing more than 400 different drug doses and drug combinations using an in vitro feeding system to determine insect mortality. The majority of drug doses approximated the peak plasma concentration in humans taking those drugs. Twenty-one drugs were found to cause >17% 12-14-day mortality compared to 8.5% mortality in the control (p < 0.05), but postliminary testing of three of the drugs, famotidine, ethambutol, and primaquine, did not demonstrate an increase in C. lectularius mortality. We also tested 23 drugs for their effects on C. lectularius fecundity. The results may have implications for understanding C. lectularius population dynamics in an infestation.

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