Differential growth of human enteric adenovirus 41 (TAK) in continuous cell lines

The subgroup F adenoviruses

“…In contrast, HEp-2 cells allowed the continuous propagation of Ad41 (D. Pieniazek et al, 1990a). There has, however, been a report where not all Ad41 strains were able to grow in these cells (Perron-Henry et al, 1988).…”

“…A rapid loss of Ad41 infectivity with passage in 293 cells has been demonstrated (D. Pieniazek et al, 1990a). In contrast, HEp-2 cells allowed the continuous propagation of Ad41 (D. Pieniazek et al, 1990a).…”

“…Reports of defective late functions are therefore few. A loss of virus infectivity with passage in 293 cells has been suggested to be due to the absence of core protein V in complete virus particles, this most likely being the result of a defect in virus assembly (D. Pieniazek et al, 1990a). Brown et al (1992) have described a block in the release of progeny Ad40 and Ad41 virus in HeLa cells, which was not present in 293 cells.…”

“…With Ad41, an average of one infectious virus particle was found to be sufficient to productively infect each 293 cell (Tiemessen & Kidd, 1990). However, reports of loss of infectivity upon passage of Ad41 in 293 cells (D. Pieniazek et al, 1990a) and poor growth of Ad40 in these cells (Chiba et al, 1983;Uhnoo et al, 1983;Brown, 1985;van Loon et al, 1985) suggest that the provision of E1 functions alone is not sufficient to overcome growth restriction.…”

Characterization of a single SA7-like VA RNA gene in subgroup F adenoviruses

“…in the presence of trans-activating genes such as adenovirus type 5 Ela (293 cells) (Brown, 1985;Pieniazek et al, 1990a;Grabow et al, 1992). It is perhaps significant in this regard that subgroup F adenoviruses can, unlike other human adenoviruses, be grown and characterized in primary monkey cells (de Jong et al, 1983).…”