Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region

Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients

“…13 In earlier studies, HLA-A*26 was found to be associated with the disease in Brazilian, 38 38 Jewish, 28 and Spanish 19 populations, and B*44:02 in the Iranian population. This is one of the most heterogenous cities in the world as a result of the great admixture between races, which promotes the unique characteristics of this population, favoring association studies, since the genes linked to the disease have a lower chance of being false positives because of their ancestry.…”

“…The question that remains is whether they are in the DR and/or in DRB1*08-DQA1*05:01-DQB1*03:01 38,39. The question that remains is whether they are in the DR and/or in DRB1*08-DQA1*05:01-DQB1*03:01 38,39.…”

Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil

“…Distinct genetic profiles ( HLA class I and II) in PF and PV groups have been determined in this region, so it is less probable that similar environmental factors trigger both forms of pemphigus. Our results add important information about the geographical distribution and changes in the epidemiological behavior of PV in the last four decades.…”

Anti‐desmogleins autoantibodies detected by ELISA and blotting in bullous pemphigoid: what do they mean?

“…PF and PV are prevalent in southeastern Brazil, but BP and pemphigus association has not been observed in this region yet. Our results agree with previous reports revealing the presence of anti‐BP180 and anti‐BP230 concomitantly with anti‐DSG1 and anti‐DSG3 antibodies but with no clinical coexistence with PF or PV, suggesting that anti‐DSG are nonpathogenic antibodies .…”