Differential house finch leukocyte profiles during experimental infection with <i>Mycoplasma gallisepticum</i> isolates of varying virulence

Bale, Natalie M; Leon, Ariel E; Hawley, Dana M.

doi:10.1080/03079457.2020.1753652

Cited by 5 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saiz del Barrio et al (2020) reported that AA increased the antioxidant capacity of the broiler's body. Horváth and Babinszky (2018) Assaying the H/L ratio and the blood cortisol concentration are valuable biomarkers in avian exposed to stressors (Bale et al, 2020;Vicuña et al, 2015). Stress increases the number of heterophils and decreases the number of lymphocytes, leading to elevating the relative proportion of neutrophils to lymphocytes (Davis et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effects of dietary ascorbic acid on oxidative stress indices, physiological and behavioural responses of domestic pigeons exposed to road transport stress

Hosseinian

2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Transport disturbs birds' welfare and health status which lead to oxidative stress and dietary ascorbic acid mitigates the adverse effects of transport stress. The present study was aimed to evaluate the impacts of ascorbic acid administration on oxidative stress indices, cortisol, H/L ratio, tonic immobility reaction and rectal temperature of pigeons exposed to road transport. A total of 80 clinically healthy pigeons were selected and randomly divided to eight equal groups as follow: (1) Ctrl -: fed by basal diet and no subjected to transport stress; (2) Ctrl+: fed by the basal diet and subjected to transport stress; (3, 4) 1DBS10 and 1DBS16: received ascorbic acid from 1 day before transport stress at doses of 10 g/100 L and 16 g/100 L of drinking water, respectively; (5, 6) 3DBS10 and 3DBS16: treated with ascorbic acid from 3 consecutive days before transport stress at doses of 10 g/100 L and 16 g/100 L, respectively and (7, 8) 7DBS10 and 7DBS16: received ascorbic acid from 7 consecutive days before the transport at doses 10 g/100 L and 16 g/100 L, respectively. Birds were transported for 3 h over a distance of about 200 km. The total antioxidant capacity, malondialdehyde and cortisol were measured before transport and at 6, 24 and 72 h post-transportation.The rectal temperature and tunic immobility reactions were recorded. Dietary ascorbic acid led to a decrease in tonic immobility response, hetrophil to lymphocyte ratio, circulating cortisol and total antioxidant capacity, and an increase in circulating malondialdehyde in pigeons exposed to transport stress compare to Ctrl+ group. In conclusion, ascorbic acid administration at dose 16 g/100 L of drinking water from 3 and 7 days before exposure to stress helps attenuate undesirable effects of oxidative stress in pigeons.

show abstract

Section: Discussionmentioning

confidence: 99%

Prophylactic effects of dietary ascorbic acid on oxidative stress indices, physiological and behavioural responses of domestic pigeons exposed to road transport stress

Hosseinian

2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…Current methods to determine virulence potential and host-pathogen interactions of mycoplasmas have relied on (i) in vivo experimental infections of the natural or alternative hosts [32][33][34][35] or on (ii) in vitro infections [21,[36][37][38][39][40]. Infections of the natural host, especially for reptiles, can be challenging but have been successfully used to confirm that both M. alligatoris [27,41] and M. agassizii [42,43] are etiologic agents of disease in alligators and tortoises, respectively.…”

Section: Introductionmentioning

confidence: 99%

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Burne,

Richey,

Schoeb

et al. 2024

Transboundary and Emerging Diseases

View full text Add to dashboard Cite

Most mycoplasmal infections result in chronic, clinically silent disease. In direct contrast, Mycoplasma alligatoris elicits a fulminant, multisystem disease in the natural host, Alligator mississippiensis (American alligator). The goals of the study were to better understand the disease in the natural host and to determine if the invertebrate model G. mellonella could serve as a surrogate alternate host. The survival of alligators infected intratracheally was dose dependent (p=0.0003), ranging from no mortality (102 CFU) to 100% mortality (108 CFU), with 60% mortality at the 104 and 105 CFU infectious dose. Microbial load in blood, joints, and brain was dose dependent, regardless of whether alligators were infected intratracheally or intravenously (p <0.002). Weight loss was similarly impacted (p <0.001). Experimental infection of the invertebrate Galleria mellonella mirrored the result in the natural host. In a dose response infection study, both larval survival curves and successful pupation curves were significantly different (p≤0.0001) and dose dependent. Infected insects did not emerge as moths (p <0.0001). Here, we describe the first study investigating G. mellonella as a surrogate model to assess the pathogenic potential of M. alligatoris. G. mellonella survival was dose dependent and impacted life stage outcome.

show abstract

Passerine Birds

Schmidt

2024

Pathology of Pet and Aviary Birds

View full text Add to dashboard Cite

Differential house finch leukocyte profiles during experimental infection with Mycoplasma gallisepticum isolates of varying virulence

Cited by 5 publications

References 54 publications

Prophylactic effects of dietary ascorbic acid on oxidative stress indices, physiological and behavioural responses of domestic pigeons exposed to road transport stress

Prophylactic effects of dietary ascorbic acid on oxidative stress indices, physiological and behavioural responses of domestic pigeons exposed to road transport stress

Galleria mellonella Invertebrate Model Mirrors the Pathogenic Potential of Mycoplasma alligatoris within the Natural Host

Passerine Birds

Contact Info

Product

Resources

About