Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck

Kadeh, Hamideh; Saravani, Shirin; Heydari, Fatemeh; Shahraki, Saeed

doi:10.1016/j.prp.2016.06.015

Cited by 9 publications

(16 citation statements)

References 19 publications

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“…MMP-10 (also known as stromelysin 2 , SL-2 ) belongs to the stromelysins subgroup of MMPs , catalyzing substrates include collagen IV, laminin, fibronectin, and elastin. MMP-10 was reported to be associated with atherosclerosis (Purroy et al , 2018), intracerebral hemorrhage (Howe et al , 2018), pulmonary hypertension (Avouac et al , 2017), and cancers (Miyata et al , 2007; Du et al , 2014; Kadeh et al , 2016; Juchniewicz et al , 2017). Recently, Guvercin et al reported that the increase of serum MMP-10 is related to acute kidney injury in nondiabetic geriatric patients (Guvercin et al , 2018).…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Lin

et al. 2019

DNA and Cell Biology

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Renal ischemia/reperfusion injury (IRI) is a main risk factor for the occurrence of delayed graft function or primary graft nonfunction of kidney transplantation. However, it lacks ideal molecular markers for indicating IRI in kidney transplantation. The present study is to explore novel candidate genes involved in renal IRI. Experimental renal IRI mouse models were constructed, and the differentially expressed genes were screened using a microarray assay. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed. The expression of genes was detected using real-time qPCR assay. Western blotting and immunohistochemistry staining assays were performed for protein determination. We identified that renal IRI induced the upregulation of SPRR2F, SPRR1A, MMP-10, and long noncoding RNA (lncRNA) Malat1 in kidney tissues for 479.3-, 4.98-, 238.1-, and 3.79-fold, respectively. The expression of miR-139-5p in kidney tissues of IRI-treated mice was decreased to 40.4% compared with the sham-operated mice. These genes are associated with keratinocyte differentiation, regeneration and repair of kidney tissues, extracellular matrix degradation and remodeling, inflammation, and cell proliferation in renal IRI. Identification of novel biomarkers involved in renal IRI may provide evidences for the diagnosis and treatment of renal IRI.

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Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Lin

et al. 2019

DNA and Cell Biology

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“…Recently, Kadeh et al also found high immunohistochemical expression of MMP-10 in tumour epithelium and stroma in SCC. Moreover, they also confirmed that the level of MMP-10 expression in tumour epithelium of grades III and II of SCC was significantly greater compared to grade I tumours [170]. Thus, MMP-10 was highly expressed in both tumour epithelium and stromal cells and may play a role in the initial stages of SCC progression [13], but does not correlate with the invasive behaviour of SCC [169].…”

Section: Stromelysinsmentioning

confidence: 71%

“…MMP-10 was entirely negative in premalignant lesions and only detected in epithelial cancer cells. By statistical analysis, MMP-10 expression does not correlate with the invasive behaviour of tumours as assessed by their histology, but may be induced by the wound healing and inflammatory matrix remodelling events associated with skin tumours [169,170]. MMP-11 seems to be associated with benign fibroblastic tumours and is a fibroblastic factor expressed in stromal cells adjacent to carcinoma cells.…”

Section: Stromelysinsmentioning

confidence: 95%

Skin Ageing and Cancer

Zhang¹,

Wang²,

Wang³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26) and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24 and MMP-25). MMPs can act on extracellular matrix (ECM) and non-ECM components affecting degradation and modulation of the ECM, growth-factor activation and cell-cell and cell-matrix signalling. In skin, MMPs are secreted by different cell types such as fibroblasts, keratinocytes, macrophages, endothelial cells, mast cells, and eosinophils. This chapter reviews the role of MMPs in maintaining skin homeostasis, skin ageing and skin cancer.

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“…It has the ability to hydrolyse extracellular matrix proteins, such as collagen type III, IV, and V, elastin, proteoglycans and glycoproteins. MMP-10 is involved in the angiogenesis process 21 and can promote cancer cell invasion and metastasis 21,22 . The present study found that APOM significantly inhibited MMP-10 mRNA expression, but did not affect the expression of MMP-10 protein.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein M inhibits proliferation and migration of larynx carcinoma cells

Xue

Zhou

et al. 2020

Sci Rep

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Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this study. The protein and mRNA levels of the samples were analysed using the Wes-ProteinSimple system (or traditional Western blot) and PCR technology, respectively. APOM protein level in cancer tissues was lower than that in paracarcinomatous (P = 0.0003) and polyp tissues (P < 0.0001). APOM overexpression significantly inhibited TU686 cell proliferation (P < 0.0001) and migration (P < 0.01), and increased expression of vitamin D receptor (VDR, P < 0.0001) as well as nuclear factor erythroid 2-like 3 (NFE2L3, P = 0.0215). In addition, matrix metalloproteinase-10 (MMP-10) mRNA level was significantly reduced in the APOM overexpression group (P = 0.0077). However, Western blot analysis showed that APOM overexpression did not change VDR, NFE2L3 and MMP-10 protein levels (P > 0.05). In summary, APOM inhibits the proliferation and migration of LC cells, but may not be related to VDR, NFE2L3 and MMP-10, which needs further study.

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Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck

Cited by 9 publications

References 19 publications

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury

Skin Ageing and Cancer

Apolipoprotein M inhibits proliferation and migration of larynx carcinoma cells

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