Differential immunometabolic responses to Delta and Omicron SARS-CoV-2 variants in golden syrian hamsters

Rajaiah, Rajesh; Pandey, Kabita; Acharya, Arpan; Ambikan, Anoop; Kumar, Narendra; Guda, Reema; Avedissian, Sean N.; Montaner, Luis J.; Cohen, Samuel M.; Neogi, Ujjwal; Byrareddy, Siddappa N.

doi:10.1016/j.isci.2024.110501

iScience

2024

DOI: 10.1016/j.isci.2024.110501

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Differential immunometabolic responses to Delta and Omicron SARS-CoV-2 variants in golden syrian hamsters

Rajesh Rajaiah,

Kabita Pandey,

Arpan Acharya

et al.

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2024

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Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis

Lee,

Lyoo

et al. 2024

Front. Immunol.

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IntroductionThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants. MethodsHere, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.ResultsBoth variants caused acute inflammation and lung pathology in intranasally infected hamsters. Principal component analysis uncovered the delta variant significantly altered lung metabolite levels between the pre- and post-infection states. Additionally, metabolic pathways determined by assessment of metabolites and genes in lung revealed significant alterations in arginine biosynthesis, glutathione metabolism, and tryptophan metabolism upon infection with both variants and closely linked to inflammatory cytokines, indicating immune activation and oxidative stress in response to both variants. These metabolic changes were also evident in the serum, validating the presence of systemic alterations corresponding to those identified in lung. Notably, the delta variant induced a more robust metabolic regulation than the omicron variant. DiscussionThe study suggests that multi-omics is a valuable approach for understanding immunometabolic responses to infectious diseases, and providing insights for effective treatment strategies.

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Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis

Lee,

Lyoo

et al. 2024

Front. Immunol.

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show abstract

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Differential immunometabolic responses to Delta and Omicron SARS-CoV-2 variants in golden syrian hamsters

Cited by 1 publication

References 107 publications

Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis

Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis

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