Differential Impact of Acute High-Intensity Exercise on Circulating Endothelial Microparticles and Insulin Resistance between Overweight/Obese Males and Females

Durrer, Cody; Robinson, Emily; Wan, Zhongxiao; Martinez, Nic; Hummel, Michelle L.; Jenkins, Nathan T.; Kilpatrick, Marcus W.; Little, Jonathan P.

doi:10.1371/journal.pone.0115860

Cited by 37 publications

(52 citation statements)

References 61 publications

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“…Some recent studies have begun to examine these issues, although the sex differences remain unclear with some studies reporting lower and others higher resting levels of CD62E+ MPs in sedentary younger women compared with men (Durrer et al , 2015; Gustafson et al , 2015). In addition, some studies are beginning to explore MP responses to an acute bout of aerobic exercise and find differential responses between men and women in CD62E+ (Durrer et al , 2015; Lansford et al , 2016; Shill et al , 2018) and CD34+ MPs (Lansford et al , 2016), suggesting sex differences in responses to vascular stressors with exercise. Thus, future studies specifically designed to examine mechanisms related to sex differences in various populations and in response to an exercise or nutritional intervention might provide better indication as to the use of MPs as sex-specific biomarkers of CVD risk.…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes and older age contribute to elevated plasma microparticle concentrations independent of chronic stroke

Landers‐Ramos

Serra

Blumenthal

et al. 2018

Experimental Physiology

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The elevated circulating concentration of endothelial microparticles (MPs) may provide an index of the extent and nature of cellular damage in chronic stroke. The purpose of this study was to determine the circulating concentrations of CD31 /CD42b , CD62E and CD34 MPs in chronic stroke subjects, focusing on the effects of chronic stroke by comparison with both older adults without a history of stroke but with type 2 diabetes mellitus (T2DM) and older and young healthy controls. Plasma from three groups of sedentary older (50-75 years) men and women (chronic stroke, T2DM or older healthy) as well as a group of younger (18-39 years) healthy controls was isolated from fasting blood, and CD31 /CD42b , CD62E and CD34 MPs were quantified using flow cytometry (n = 17/group). Concentrations of CD31 /CD42b and CD62E MPs were higher in the T2DM group (P < 0.05), but not chronic stroke, compared to older and younger healthy adults. CD62E MP and CD34 MP concentrations were elevated in the older compared to younger adults (P < 0.05 for both). Sub-analyses excluding chronic stroke subjects who were also diagnosed with diabetes [stroke (diabetes )] revealed lower CD31 /CD42b (P < 0.05) and CD62E (P = 0.08) MPs in the stroke (diabetes ) group compared to the T2DM group. CD31 /CD42b MP and CD62E MP concentrations were each associated with fasting glucose levels and CD31 /CD42b MPs also were associated with triglyceride levels. As MPs have been proposed as potential targets for diagnosing, treating and identifying the clinical progression of T2DM, our study provides further support for the use of CD31 /CD42b and CD62E MPs in the clinical progression of T2DM and associated vascular complications.

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Section: Discussionmentioning

confidence: 99%

Type 2 diabetes and older age contribute to elevated plasma microparticle concentrations independent of chronic stroke

Landers‐Ramos

Serra

Blumenthal

et al. 2018

Experimental Physiology

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“…Microparticle isolation and identification was based on accepted methodology, as described by Jenkins et al (2013) and Durrer et al (2015). After 15 min of supine rest, a baseline blood sample was collected from the radial artery.…”

Section: Methodsmentioning

confidence: 99%

Passive heat stress reduces circulating endothelial and platelet microparticles

Bain

Ainslie

Bammert

et al. 2017

Experimental Physiology

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What is the central question of this study? Does passive heat stress of +2°C oesophageal temperature change concentrations of circulating arterial endothelial- and platelet-derived microparticles in healthy adults? What is the main finding and its importance? Concentrations of circulating endothelial- and platelet-derived microparticles were markedly decreased in heat stress. Reductions in circulating microparticles might indicate favourable vascular changes associated with non-pathological hyperthermia. Interest in circulating endothelial- and platelet-derived microparticles (EMPs and PMPs, respectively) has increased because of their potential pathogenic role in vascular disease and as biomarkers for vascular health. Hyperthermia is commonly associated with a pro-inflammatory stress but might also provide vascular protection when the temperature elevation is non-pathological. Circulating microparticles might contribute to the cellular adjustments and resultant vascular impacts of hyperthermia. Here, we determined whether circulating concentrations of arterial EMPs and PMPs are altered by passive heat stress (+2°C oesophageal temperature). Ten healthy young men (age 23 ± 3 years) completed the study. Hyperthermia was achieved by circulating ∼49°C water through a water-perfused suit that covered the entire body except the hands, feet and head. Arterial (radial) blood samples were obtained immediately before heating (normothermia) and in hyperthermia. The mean ± SD oesophageal temperature in normothermia was 37.2 ± 0.1°C and in hyperthermia 39.1 ± 0.1°C. Concentrations of circulating EMPs and PMPs were markedly decreased in hyperthermia. Activation-derived EMPs were reduced by ∼30% (mean ± SD; from 61 ± 8 to 43 ± 7 microparticles μl ; P < 0.05) and apoptosis-derived EMPs by ∼45% (from 46 ± 7 to 23 ± 3 microparticles μl ; P < 0.05). Likewise, circulating PMPs were reduced by ∼75% in response to hyperthermia (from 256 ± 43 to 62 ± 14 microparticles μl ). These beneficial reductions in circulating EMPs and PMPs in response to a 2°C increase in core temperature might partly underlie the reported vascular improvements following therapeutic bouts of physiological hyperthermia.

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Section: Exercise and Cardiovascular Stressmentioning

confidence: 99%

“…Durrer et al [92] took blood 18 h after high-intensity exercise and found an increase in endothelial MVs. However, intriguingly, this was only evident in females, with a decrease in endothelial MVs in males [92]. Interestingly, the interpretation of levels may be further complicated by the pre-existing fitness of individuals taking part in studies as a 5-day reduction in daily exercise in normally active young men leads to increased CD31 + CD42b − (apoptotic), but not CD62E + (activated), endothelial-cell-derived MVs [93].…”

Section: Exercise and Cardiovascular Stressmentioning

confidence: 99%

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

et al. 2015

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Interest in cell-derived microvesicles (or microparticles) within cardiovascular diagnostics and therapeutics is rapidly growing. Microvesicles are often measured in the circulation at a single time point. However, it is becoming clear that microvesicle levels both increase and decrease rapidly in response to certain stimuli such as hypoxia, acute cardiac stress, shear stress, hypertriglyceridaemia and inflammation. Consequently, the levels of circulating microvesicles will reflect the balance between dynamic mechanisms for release and clearance. The present review describes the range of triggers currently known to lead to microvesicle release from different cellular origins into the circulation. Specifically, the published data are used to summarize the dynamic impact of these triggers on the degree and rate of microvesicle release. Secondly, a summary of the current understanding of microvesicle clearance via different cellular systems, including the endothelial cell and macrophage, is presented, based on reported studies of clearance in experimental models and clinical scenarios, such as transfusion or cardiac stress. Together, this information can be used to provide insights into potential underlying biological mechanisms that might explain the increases or decreases in circulating microvesicle levels that have been reported and help to design future clinical studies.

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Differential Impact of Acute High-Intensity Exercise on Circulating Endothelial Microparticles and Insulin Resistance between Overweight/Obese Males and Females

Cited by 37 publications

References 61 publications

Type 2 diabetes and older age contribute to elevated plasma microparticle concentrations independent of chronic stroke

Type 2 diabetes and older age contribute to elevated plasma microparticle concentrations independent of chronic stroke

Passive heat stress reduces circulating endothelial and platelet microparticles

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

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