The agricultural sector provides employment and income to the majority of Myanmar’s population. The sector, however, is extremely susceptible to severe weather, rising temperatures, and changes in precipitation. A lack of knowledge about farming communities’ climate change vulnerabilities, as well as the insufficient integration of policies and programs, is a constraint to climate change adaptation in agriculture sectors. This paper analyzes the drivers of the agricultural sector’s vulnerability to climate change and highlights the key production systems that are most at risk in Myanmar. The paper examines historical climate information and the anticipated effects of climate change. We include an in-depth literature review and summaries of climate change adaptation efforts in agriculture sectors, along with recommendations for targeted, locally appropriate actions to strengthen the resilience of the agricultural sector. Farm households use a combination of scientific and indigenous adaptation strategies to cope with the effects of climate change. Additionally, the study reviews Myanmar’s institutional framework for climate action and government priorities for adaptation measures, emphasizes the urgent need for climate action in agriculture sectors, and calls for more research and development efforts on the effects of climate change on rural livelihoods and agriculture.