Differential impairment of social cognition factors in bipolar disorder with and without psychotic features and schizophrenia

Thaler, Nicholas S.; Allen, Daniel N.; Sutton, Griffin P.; Vertinski, Mary; Ringdahl, Erik N.

doi:10.1016/j.jpsychires.2013.09.010

Cited by 61 publications

(51 citation statements)

References 41 publications

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“…Group differences on the auditory affect recognition condition of the BLERT also replicated previous findings of impaired emotion recognition in the auditory domain in SZ and BD+ . We did not find differences between the BD+ and BD− groups on the visual affect recognition condition or the auditory–visual affect recognition condition of the task, suggesting that psychosis may specifically be related to impairments in emotion recognition of prosody.…”

Section: Discussionsupporting

confidence: 88%

Auditory processing deficits in bipolar disorder with and without a history of psychotic features

et al. 2015

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Section: Discussionsupporting

confidence: 88%

Auditory processing deficits in bipolar disorder with and without a history of psychotic features

et al. 2015

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“…Previous research has reported that the presence of psychotic symptoms is related to poor neurocognitive performance Thaler et al, 2013). In addition, Levy et al, 2013 found that those patients with psychotic symptoms in their last episode experienced lower psychosocial functioning compared to remitted patients without psychotic symptoms.…”

Section: Discussionmentioning

confidence: 95%

Predictors of functional outcome after a manic episode

Bonnín¹,

Reinares²,

Hidalgo‐Mazzei³

et al. 2015

Journal of Affective Disorders

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“…Some authors have pointed out similar emotion‐processing deficits in both SCZ and BD‐P compared to HC, which did not improve after treatment . Thaler et al demonstrated that BD‐P and BD‐NP were different in terms of emotional processing, while both groups, as well as SCZ, significantly differed from HC in theory of mind (ToM) …”

Section: Resultsmentioning

confidence: 99%

Biological aspects and candidate biomarkers for psychotic bipolar disorder: A systematic review

Buoli

Caldiroli

Melter

et al. 2016

Psychiatry Clin Neurosci

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Aim:We carried out a systematic review of the available literature about potential biomarkers of psychotic bipolar disorder (BD-P), a specific subset presenting worse outcome and greater risk of relapse than non-psychotic bipolar disorder (BD-NP). Methods:We searched the main psychiatric databases (PubMed, ISI Web of Knowledge, PsychInfo). Only original articles with the main topic of BD-P compared to schizophrenia/BD-NP/healthy controls (HC) written in English from 1994 to 2015 were included.Results: BD-P patients presented higher kynurenic acid levels in the cerebrospinal fluid, elevated antiSaccharomyces cerevisiae antibodies levels, and lower serum levels of dehydroepiandrosterone sulfate and progesterone than BD-NP/HC. Event-related potentials abnormalities have been identified in BD-P with respect to BD-NP. BD-P patients also presented bigger ventricles but similar hippocampal volumes compared to BD-NP/HC. Although the results are contrasting, some cognitive deficits seemed to be related to the psychotic dimension of bipolar affective disorder, such as impairment in verbal/logical memory, working memory, verbal and semantic fluency and executive functioning. Finally, polymorphisms of genes, such as NRG1, 5HTTLPR (s), COMT, DAOA and some chromosome regions (16p12 and 13q), were positively associated with BD-P. Conclusion:Data about the identification of specific biomarkers for BD-P are promising, but most of them have not yet been replicated. They could lead the clinicians to an early diagnosis and proper treatment, thus ameliorating outcome of BD-P and reducing the biological changes associated with a long duration of illness. Further studies with bigger samples are needed to detect more specific biological markers of the psychotic dimension of bipolar affective disorder.Key words: biomarkers, bipolar disorder, psychoneurobiology, psychopathology, psychotic symptoms. B IOLOGICAL MARKERS, AS indicators of a biological or a pathological state and as parameters that can be measured objectively, could provide a valuable support to the clinical decision-making process in many branches of medicine, including psychiatry. Several findings in the field of mood disorders could provide the background for the identification of potential specific and objective biomarkers, which could be an important aid to better understand the course of illness, the mechanisms of vulnerability and of disease expression.A recent paper describing the work of the Biomarkers Network from the International Society for Bipolar Disorders (ISBD-BIONET) cited neuroimaging and genetic findings in bipolar affective disorder (BPAD) (e.g. the loss of gray matter, the altered activation of anterior temporal, ventral prefrontal and subcortical regions in response to emotional stimuli, the identification of several potential candidate genes associated with increased risk for developing *Correspondence: Alice Caldiroli, MD, Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, via Francesco Sforza ...

show abstract

Differential impairment of social cognition factors in bipolar disorder with and without psychotic features and schizophrenia

Cited by 61 publications

References 41 publications

Auditory processing deficits in bipolar disorder with and without a history of psychotic features

Auditory processing deficits in bipolar disorder with and without a history of psychotic features

Predictors of functional outcome after a manic episode

Biological aspects and candidate biomarkers for psychotic bipolar disorder: A systematic review

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