Differential in vitro cytotoxicity of (−)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity

Babich, H.; Krupka, Magdalena; Nissim, H.A.; Zuckerbraun, Harriet L.

doi:10.1016/j.tiv.2004.09.001

Cited by 114 publications

(73 citation statements)

References 44 publications

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“…Corroborating our findings, Babich et al (61) reported that catechin exhibited a lower toxicity than other compounds derived from catechin against HSC-2 carcinoma cells and HGF-2 fibroblasts. Although additional tests, such as reproductive toxicity analysis and mutagenesis evaluation, must be performed, the present results show that (ϩ)-catechin hydrate plus fluconazole is probably safe for use for treatment of acute infections in vivo.…”

Section: Figsupporting

confidence: 90%

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Silva

Neto

Campos

et al. 2014

Antimicrob Agents Chemother

110

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Section: Figsupporting

confidence: 90%

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Silva

Neto

Campos

et al. 2014

Antimicrob Agents Chemother

110

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“…In fact, it has been reported by several groups that ECG has better anti-cancer effects. 6,28 In summary, our results demonstrate that ECG can inhibit β-catenin signaling and cyclin D1 expression, leading to suppression of cell growth and induction of apoptosis in HNSCC. Therefore, ECG has potential use as a chemopreventive agent in HNSCC, and the future study of its clinical use may be worthwhile.…”

Section: Discussionmentioning

confidence: 63%

Growth inhibition and apoptosis by (−)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells

Lim

Lee

Song

et al. 2006

European Journal of Cancer

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In recent studies, green tea components have been shown to induce cell growth arrest and apoptosis in head and neck squamous cell carcinoma (HNSCC) cells. In this report, we have investigated the effects of epicatechin gallate (ECG), one of the catechins in green tea, on anti-cancer activity in vitro. We found that cyclin D1 was highly expressed in HNSCC cells, and ECG suppressed 90% of cyclin D1 expression in SCC7 cells. We have also evaluated the effect of ECG on cell growth and apoptosis, showing that ECG (50 μM) exhibited a significant inhibition (50%) on the growth of SCC7 cells via G1 cell cycle arrest. ECG suppressed cyclin D1 in SCC7 cells in a dose-and time-dependent manner, and the suppression of the β-catenin pathway by ECG is one of the mechanism to facilitate ECG-induced cell growth arrest. These results suggest that ECG has a potential usage as a chemopreventive agent in HNSCC.

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“…Interestingly, tea catechins also inhibit non-cancer (human embryonic lung fibroblast) cell proliferation (unpublished data from our own group), which indicates the suppression of cell growth is a non-specific effect. The in vitro cytotoxicity of tea catechins to cancer and normal cells has also been reported in previous studies (31,32). Although the effects of tea catechins on inhibiting human cancer cell proliferation have been reported in several studies (18,30), the precise mechanism of suppressing cancer cell growth is unclear.…”

Section: Discussionmentioning

confidence: 67%

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Zhong

Dong

Yang

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet the precise mechanism of lung cancer prevention by green tea catechins remains unclear. microRNAs (miRs) are a class of 21-24 nucleotide small non-coding RNAs and play critical roles throughout cellular development and regulation. Emerging evidence demonstrates that tea catechins influence the expression of miRs in human cancer cells to inhibit tumorigenesis. Both let-7a-1 and let-7g were detected in the human lung cancer cells treated with tea catechins. The cell viability and cell cycle were analyzed after tea catechins treatment. In the present study, we found that tea catechins upregulated the tumor-suppressor miRs, let-7a-1 and let-7g, in lung cancer cell lines. The upregulation of let-7a/7g repressed the expression of their targets, C-MYC and the regulatory protein of LIN-28, at the mRNA and protein levels. Moreover, the cell growth assay indicated that tea catechins significantly inhibited cell proliferation, and the flow cytometric analysis revealed an increase in the number of cells in the G2/M phase and a decrease in the number of cells in the S phase after treatment with tea catechins. These observations suggest that green tea catechins mediate the inhibition of proliferation of lung cancer cells through the let-7 signaling pathway.

show abstract

Differential in vitro cytotoxicity of (−)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity

Cited by 114 publications

References 44 publications

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Growth inhibition and apoptosis by (−)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

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