Differential induction of enzymes and genes involved in lipid metabolism in liver and visceral adipose tissue of juvenile yellow catfish Pelteobagrus fulvidraco exposed to copper

Chen, Qiliang; Luo, Zhi; Pan, Ya–Xiong; Zheng, Jia; Zhu, Qing–Ling; Sun, Luying; Zhuo, Mei-Qin; Hu, Wei

doi:10.1016/j.aquatox.2013.04.003

Cited by 37 publications

(61 citation statements)

References 49 publications

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“…Its expression was significantly down-regulated, possibly indicating that waterborne Zn exposure inhibited long-chain FA synthesis. However, the mRNA levels of genes related to lipogenesis, such as G6PD, 6PGD, ME22, ACC23 and FAS24, were not significantly influenced by waterborne Zn exposure. In general, lipid homeostasis is characterized by the balance between lipolysis and lipogenesis.…”

Section: Discussionmentioning

confidence: 85%

Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta

Huang

Shi

et al. 2016

Sci Rep

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Previous studies have investigated the physiological responses in the liver of Synechogobius hasta exposed to waterborne zinc (Zn). However, at present, very little is known about the underlying molecular mechanisms of these responses. In this study, RNA sequencing (RNA-seq) was performed to analyse the differences in the hepatic transcriptomes between control and Zn-exposed S. hasta. A total of 36,339 unigenes and 1,615 bp of unigene N50 were detected. These genes were further annotated to the Nonredundant protein (NR), Nonredundant nucleotide (Nt), Swiss-Prot, Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG) and Gene Ontology (GO) databases. After 60 days of Zn exposure, 708 and 237 genes were significantly up- and down-regulated, respectively. Many differentially expressed genes (DEGs) involved in energy metabolic pathways were identified, and their expression profiles suggested increased catabolic processes and reduced biosynthetic processes. These changes indicated that waterborne Zn exposure increased the energy production and requirement, which was related to the activation of the AMPK signalling pathway. Furthermore, using the primary hepatocytes of S. hasta, we identified the role of the AMPK signalling pathway in Zn-influenced energy metabolism.

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Section: Discussionmentioning

confidence: 85%

Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta

Huang

Shi

et al. 2016

Sci Rep

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show abstract

“…Our study also showed that SREBP-1 and PPARc transcription was positively correlated with the mRNA levels of 6PGD, and the activities of 6PGD and ICDH, and positively correlated with the mRNA levels of G6PD, supporting the notion. Similarly, Chen et al (2013) indicated that SREBP-1 expression was positively related to mRNA level of genes involve in lipogenesis, including 6PGD, ME, ICDH and FAS genes in liver of yellow catfish. Zheng et al (2013) reported a positive correlation between mRNA level of PPARc and genes encoding lipogenesis enzymes (G6PD, 6PGD, FAS) in liver of yellow catfish.…”

Section: Discussionmentioning

confidence: 94%

Effects of recombinant human leptin administration on hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco: In vivo and in vitro studies

Song

Tan

et al. 2015

General and Comparative Endocrinology

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“…Histological and histochemical analyses were performed according to our previously described methods (Chen et al, 2012(Chen et al, , 2013c. Briefly, for histological observation, samples were dehydrated in graded ethanol concentrations and embedded in paraffin wax.…”

Section: Histological and Histochemical Analysesmentioning

confidence: 99%

Differential effects of dietary copper deficiency and excess on lipid metabolism in yellow catfish Pelteobagrus fulvidraco

Chen

Luo

et al. 2015

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Differential induction of enzymes and genes involved in lipid metabolism in liver and visceral adipose tissue of juvenile yellow catfish Pelteobagrus fulvidraco exposed to copper

Cited by 37 publications

References 49 publications

Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta

Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta

Effects of recombinant human leptin administration on hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco: In vivo and in vitro studies

Differential effects of dietary copper deficiency and excess on lipid metabolism in yellow catfish Pelteobagrus fulvidraco

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