Differential induction of indoleamine-2,3-dioxygenase (IDO) by interferon-γ in human gyneocologic cancer cells

Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer

“…Concerning the IDO expression by the neighboring to the tumor non-malignant lung tissue, it could be attributed to a degree of infiltration by the same as above cell types. Moreover, tumor-derived soluble factors, like interferon, 16,17 a known inducer of IDO, 18 could to a greater extent be responsible, by perfusing the surrounding pulmonary tissue and stimulating in this way even normal cellular elements (e.g., macrophages) to produce IDO. Finally, chronic pulmonary inflammation, usually coexisting in lung cancer, could by itself induce IDO expression in the non affected peri-tumoral lung areas.…”

Predominant Contribution of IFN-.BETA. Expression to Apoptosis Induction in Human Uterine Cervical Fibroblast Cells by Influenza-Virus Infection

“…26) It has been previously reported that IFN-g 27,28) is the IFN specie that induces IDO to improve cell viability, and that the activation of IDO through IFN-g may include participation of IRF-1, dsRNA, and PKR. 29) However, IFN-g gene mRNA expression could not be observed in IV-infected HCF.…”

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

“…The expression of IDO in human ovarian and colon carcinomas is also associated with poor prognosis and reduced survival [8,9]. Finally, because IDO expression is strongly induced by interferon-gamma [10], even tumors that do not constitutively express IDO may do so when exposed to inflammatory conditions, e.g. resulting from an ongoing immune response.…”