Differential influence of maternal and fetal pregnancy factors on the in-vitro induction of human regulatory T cells: a preliminary study

Marcoli, Natalie; Østensen, Monika; Portmann-Lanz, C. Bettina; Surbek, Daniel; Villiger, Peter M.; Förger, Frauke

doi:10.4414/smw.2015.14172

Cited by 2 publications

(2 citation statements)

References 44 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This unique subpopulation of T cells has shown to be involved in preventing autoimmunity, and tolerating allogeneic organ grafts in rodent models. The suppressive activity of Tregs is mediated either in a cell‐cell contact‐mediated fashion via cytotoxic T lymphocyte‐associated protein 4 (CTLA‐4) or by the secretion of cytokines such as transforming growth factor beta (TGF‐β) or interleukin (IL)‐10 . In 1995, Sakaguchi et al characterized a subpopulation of T cells with suppressive capacity .…”

Section: Regulatory T Cells: Phenotype and Functionmentioning

confidence: 99%

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Craenmehr

Heidt

Eikmans

et al. 2016

HLA

View full text Add to dashboard Cite

Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.

show abstract

Section: Regulatory T Cells: Phenotype and Functionmentioning

confidence: 99%

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Craenmehr

Heidt

Eikmans

et al. 2016

HLA

View full text Add to dashboard Cite

show abstract

“…With respect to Tregs, a research report has demonstrated that not only the numbers of Tregs are decreased but the function of Tregs are also impaired in preeclampsia [66]. Other researchers have shown, albeit in small numbers, lower peripheral and decidual Treg sub-types in pregnancies complicated with preeclampsia [67][68][69][70][71][72]. In addition, derangement in the differentiation of recent thymic emigrant (RTE) Tregs have been observed in women with PE [73,74].…”

Section: Tregs and Preeclampsiamentioning

confidence: 99%

T Receptor Lymphocytes - Can they be Used as a Low Cost Predictive Tool for Dysfunctional Placental Diseases?

Sengupta¹,

Tan²,

Chaouat³

2016

Ann Clin Lab Res

View full text Add to dashboard Cite

Background: Regulatory T cells (Tregs) are lymphocytes originating in the bone marrow. They mature in the thymus and help fight inflammation in humans. Tregs are involved in the maternal acceptance of the allogeneic fetus.Objectives: This review focuses on the role of Tregs i.e. the origins, development and function in pregnancy, as well as their diagnostic and therapeutic value in pregnancy pathologies such as miscarriage and preeclampsia (PE).Methods: A MeSH and text word PubMed search through August 2016 was performed using the keywords: T receptor lymphocytes; subsets of regulatory T cells: regulatory T cells; controlled trials; pregnancy and treatment. Additional databases searched included; Google scholar, database of abstracts of reviews of effects (DARE),Cochrane Library, NIHR central portfolio management system, UK database of uncertainties about the effects of treatments (DUETs), trip database, health on the NET Northern Ireland (HONNI), the knowledge network Scotland, the Geneva foundation for medical education and research (GFMER) and ClinicalTrials.gov. Findings and conclusions:The origins, development, function and the role of Tregs in the pathophysiology of pregnancy and its complications have not been fully clarified. A lack of Treg cells or defective production due to placental disease or an altered immune response are found in women with sub-fertility, recurrent miscarriage, PE and preterm birth. However, clinical studies to date have involved small numbers of women (with a paucity of randomized controlled trials). Future research focusing on Tregs and their diagnostic and therapeutic value in the management of pregnancy complications are urgently needed.

show abstract

Differential influence of maternal and fetal pregnancy factors on the in-vitro induction of human regulatory T cells: a preliminary study

Abstract: Compared with circulating maternal factors, placental- and fetal-derived factors appear to exert a more powerful effect on numerical changes of Treg, thereby supporting fetomaternal tolerance during human pregnancy.

Cited by 2 publications

References 44 publications

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

T Receptor Lymphocytes - Can they be Used as a Low Cost Predictive Tool for Dysfunctional Placental Diseases?

Contact Info

Product

Resources

About