Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats

Kotyzová, Dana; Bludovská, Monika; Eybl, V.

doi:10.1016/j.etap.2013.09.003

Cited by 27 publications

(19 citation statements)

References 38 publications

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“… 29 In the present study, arsenic-treated animals showed significantly increased levels of free radical-mediated LPO and decreased levels of GSH, CAT, and GR compared to control. These changes agreed by other researchers such as Flora et al, 24 , 25 Messarah et al, 41 El-Demerdash et al, 45 Jain et al, 46 Manimaran et al, 47 Kotyzová et al, 48 and Mohanta et al 49 The increase in O 2 •− by arsenic decreases CAT activity. 50 , 51 The decreased CAT activity may relate to their effective functioning for elimination of hepatic ROS.…”

Section: Discussionsupporting

confidence: 87%

N-acetylcysteine and meso-2,3 dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats

El-Saad¹,

Alkahtani²,

Abdel‐Moneim³

2016

DDDT

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Environmental exposure to arsenic represents a serious challenge to humans and other animals. The aim of the present study was to test the protective effect of antioxidant N-acetylcysteine (NAC) either individually or in combination with a chelating agent, meso-2,3-dimercaptosuccinic acid (DMSA), against sodium arsenite oral toxicity in male rats. Five groups were used: control; arsenic group (orally administrated in a concentration of 2 mg/kg body weight [b.w.]); the other three groups were orally administrated sodium arsenite in a concentration of 2 mg/kg b.w. followed by either NAC (10 mg/kg b.w., intraperitoneally [i.p.]), DMSA (50 mg/kg b.w., i.p.) or NAC plus DMSA. Arsenic toxicity caused significant rise in serum aspartate aminotransferase, alanine aminotransferase and total bilirubin, and a significant decrease in total protein (TP) and albumin levels after 3 weeks of experimental period. In addition, arsenic-treated rats showed significantly higher arsenic content in liver and significant rise in hepatic malondialdehyde level. By contrast, sharp decreases in glutathione content and catalase and glutathione reductase activities were discernible. NAC and/or DMSA counteracted most of these physiologic and biochemical defects. NAC monotherapy was more effective than DMSA in increasing TP, while DMSA was more effective in decreasing alanine aminotransferase. The combined treatment was superior over monotherapies in recovery of TP and glutathione. Biochemical data were well supported by histopathological and ultrastructural findings. In conclusion, the combination therapy of NAC and DMSA may be an ideal choice against oxidative insult induced by arsenic poisoning.

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Section: Discussionsupporting

confidence: 87%

N-acetylcysteine and meso-2,3 dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats

El-Saad¹,

Alkahtani²,

Abdel‐Moneim³

2016

DDDT

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“…A recent work showed that a large amount of arsenic accumulates in these organs after exposure to As 2 O 3 , causing damage by ROS generation. Moreover, a significant decrease in the activity of scavenging enzymes such as catalase and glutathione peroxidase suggests a compromise of the antioxidant defense system and consequently a physiological effect on these organs [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Coadministration of N‐Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System

Silva

Borges

Silva

et al. 2015

Oxidative Medicine and Cellular Longevity

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Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water. As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered. When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight. In vitro epididymal contractility was increased in As2O3-treated animals. We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment. However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system.

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“…Briefly, binding of trivalent As to thiol-containing antioxidant, leads to series of events: decrease antioxidant activity [ 95 ], changes fatty acid composition [ 96 ], renal DNA damage and cell death modulating [Ca 2+ ] concentration [ 97 ] and downregulates Nef-2 expression [ 91 ]. Arsenic also interrupt the mitochondrial electron transport chain by inhibiting function or activity of Isocitrate dehydrogenase, α -Ketoglutarate dehydrogenase, Succinate dehydrogenase, NADH-dehydrogenase, Cytochrome c oxidase, increasing LPO and decreasing antioxidant activity in mitochondria [ 98 ].…”

Section: Arsenic (As) and Kidneymentioning

confidence: 99%

Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review

2018

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HighlightsOxidative Stress is the key mechanism involved in Lead, Mercury, Cadmium and Arsenic-induced kidney toxicity.Proteinuria is common to all heavy metals as manifestation of kidney damage.Chelation therapy is recommended based on the dose size of heavy metals, though fatal drawbacks limit their success.Possible effectiveness of plants and plants derived compound against heavy metals is due to their antioxidant activity.Other possible effectiveness of plant includes protecting integrity of mitochondria, Ca2+ homeostasis and apoptosis regulation.

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Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats

Cited by 27 publications

References 38 publications

N-acetylcysteine and meso-2,3 dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats

N-acetylcysteine and meso-2,3 dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats

The Coadministration of N‐Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System

Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review

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