Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

Mei, Fangchao; Zuo, Teng; Zhao, Liang; Shi, Qiao; Xiang, Mingwei; Hong, Yupu; Li, Man; Wang, Weixing

doi:10.1007/s00404-018-4668-x

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Maternal ARDS patients have been reported to have a high rate of fetal death, spontaneous preterm labor, and fetal heart rate abnormalities. Animal model research has found that cases of APIP in rats had pro-inflammatory cytokines and oxidative stress involved in the development of systemic complications such as lung and renal damage (29)(30)(31)(32). ARDS is a critical concern in fetal intrauterine death because of the lack of uteroplacental perfusion, pro-inflammatory cytokines, and oxidative stress.…”

Section: Gestation Week and Fetal Intrauterine Death Were Risk Factors For Acute Pancreatitis Severitymentioning

confidence: 99%

Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

Shi

et al. 2021

Front. Pediatr.

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Background: Acute pancreatitis in pregnancy is a rare but highly life-threatening gestational and perinatal disease.Objective: This study aimed to identify the risk factors for fetal death and acute pancreatitis severity.Methods: This retrospective cohort study enrolled patients with acute pancreatitis in pregnancy in our center from January 1, 2012, to August 1, 2020, and classified them according to two clinical endpoints, fetal outcome and disease severity. The groups were examined and compared according to gestational week, etiology, gravidity and parity, complications in pre- and post-delivery, and medical history. Logistic regression analysis was performed to identify the independent risk factors for fetal death and acute pancreatitis severity.Results: Of the 90 enrolled patients, 28 (31.1%) had fetal death and 43 (47.8%) had severe acute pancreatitis. Logistic regression analysis showed that pre-delivery acute respiratory distress syndrome (OR, 5.8; 95% CI, 1.5–22.4; p = 0.010) and gestational week (OR, 0.9; 95% CI, 0.8–1.0; p = 0.011) were risk factors for fetal death. Gestation week (OR, 1.2; 95% CI, 1.1–1.3; p = 0.003) and fetal intrauterine death (OR, 5.9; 95% CI, 1.8–19.4; p = 0.003) were risk factors for severe acute pancreatitis.Conclusions: Pre-delivery acute respiratory distress syndrome and gestational week were independent risk factors for fetal death. Fetal intrauterine death and gestational week were independent risk factors for severe acute pancreatitis.

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Section: Gestation Week and Fetal Intrauterine Death Were Risk Factors For Acute Pancreatitis Severitymentioning

confidence: 99%

Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

Shi

et al. 2021

Front. Pediatr.

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“…Кроме того, проведенными ранее исследованиями доказано, что высокие показатели эндогенной интоксикации у беременных с ОП способствуют нарушениям коагуляционного гомеостаза и процессам микроциркуляции в маточно-плацентарном бассейне, которые также могут привести к гибели плодного яйца или фетоплацентарной недостаточности [11,12]. Последние сообщения зарубежных авторов, основанные на экспери- [21,26,29]. Оценка параметров УЗИ с допплерометрией у беременных с ОП позволила нам констатировать значимые изменения качественных параметров маточной гемодинамики, свидетельствующих о нарушениях маточно-плацентарного кровотока при данной патологии.…”

Section: Discussionunclassified

Features of the Synthesis of Cytokines and Placental Dysfunction in Pregnant Women With Acute Pancreatitis

Хворостухина¹,

Новичков²

2019

Med. immunol.

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Дополнительное использование дискретного плазмафереза и препаратов прогестерона способствовало восстановлению баланса про-и противовоспалительных цитокинов уже к 3-м суткам лечения, предотвращая их длительное негативное воздействие на структуру и функцию маточно-плацентарного комплекса. Сочетание беременности с острым панкреатитом сопровождается диссоциацией иммунного ответа с преобладанием Th1-цитокинов на фоне угнетения апоптоза и развития плацентарной дисфункции. Применение разработанного способа комплексного лечения позволяет сократить частоту угрожающего прерывания беременности при развитии острого панкреатита-в 3 раза, уменьшить число преждевременных родов-в 13 раз, а потери беременности свести до нуля.

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“…On one hand, the animal model of APIP mainly focus on organ damage of feta, such as liver, lung, kidney damage. [13][14][15] On the other hand, the clinical model of APIP mainly focus on the severe APIP and organ failure in APIP. [5,16] We summarized the detailed results in Table 5.…”

Section: Principal Ndingmentioning

confidence: 99%

Acute Pancreatitis in Pregnancy: A Propensity Score Matching Analysis and Dynamic Nomogram for Risk Assessment

Tang,

Chen,

Huang

et al. 2024

Dig Dis Sci

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BACKGROUND: Acute pancreatitis is easily confused with abdominal pain symptoms, and it could lead to serious complications for pregnant women and fetus, the mortality was as high as 3.3% and 11.6%-18.7%, respectively. However, there is still lack of sensitive laboratory markers for early diagnosis of APIP and authoritative guidelines to guide treatment. ONJECTIVE:The purpose of this study was to explore the risk factors of acute pancreatitis in pregnancy, establish and evaluate the dynamic prediction model of risk factors in acute pancreatitis in pregnancy patients.STUDY DESIGN: Clinical data of APIP patients and non-pregnant acute pancreases patients who underwent regular antenatal check-ups during the same period were collected. The data set after propensity matching was randomly divided into training set and veri cation set at a ratio of 7:3. The model was constructed by using Logistic regression, least absolute shrinkage and selection operator regression, R language and other methods. The training set model was used to construct the diagnostic nomogram model and the validation set was used to validate the model. Finally, the accuracy and clinical practicability of the model were evaluated. RESULTS: A total of 111 APIP were included. In all APIP patients, biliary pancreatitis was the most important reason (62.1%). The levels of serum amylase, creatinine, albumin, triglyceride, high density lipoprotein cholesteroland apolipoprotein A1 were signi cantly different between the two groups. The propensity matching method was used to match pregnant pancreatitis patients and pregnant non-pancreatic patients 1:1 according to age and gestational age, and the matching tolerance was 0.02. The multivariate logistic regression analysis of training set showed that diabetes, triglyceride, Body Mass Index, white blood cell, C-reactive protein were identi ed and entered the dynamic nomogram. The area under the ROC curve of the training set was 0.942 and in validation set was 0.842. The calibration curve showed good predictive in training set, the calibration performance in the validation set was acceptable. The calibration curve showed the consistency between the nomogram model and the actual probability. CONCLUSION:The dynamic nomogram model we constructed to predict the risk factors of acute pancreatitis in pregnancy has high accuracy, discrimination and clinical practicability.

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Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

Abstract: Mitogen-activated protein kinases may play an important role in renal injury in rat models of ANPIP.

Cited by 6 publications

References 34 publications

Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

Features of the Synthesis of Cytokines and Placental Dysfunction in Pregnant Women With Acute Pancreatitis

Acute Pancreatitis in Pregnancy: A Propensity Score Matching Analysis and Dynamic Nomogram for Risk Assessment

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