Differential Lateral Septal Vasopressin in Wild-type Rats: Correlation with Aggression

Everts, H.; Ruiter, A.J.H. de; Koolhaas, Jaap M.

doi:10.1006/hbeh.1997.1375

Cited by 101 publications

(51 citation statements)

References 42 publications

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“…33 Aggressive behavior is correlated with VP immunoreactivity in fibers in the lateral septum (whose VP cell bodies are located in the BNST). 48 Thus, our functional mapping of this chemosensory responsive circuitry using Fos (Figure 4) is important because it confirms that chemosensory stimuli reach the chemosensory-responsive neural circuit. The increased Fos-like immunoreactivity induced by exposure to the intruder animal demonstrates that V1bRKO males detect and transmit chemosensory information as do WT littermates.…”

Section: Discussionmentioning

confidence: 59%

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoring the need for a better understanding of the neural bases of aggression. Vasopressin, acting through its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much less attention due to a lack of specific drugs. Here we report that mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition. By contrast, they perform normally in all the other behaviors that we have examined, such as sexual behavior, suggesting that reduced aggression and social memory are not simply the result of a global deficit in sensorimotor function or motivation. Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain. We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries. Molecular Psychiatry (2002) 7, 975-984.

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Section: Discussionmentioning

confidence: 59%

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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“…Thus, although increased V1aR binding in this region has been implicated in social recognition and anxiety in male rodents (Bielsky et al, 2005) and in male aggression and territoriality (Everts et al, 1997;Bester-Meredith et al, 2005;Rosen et al, 2006), this tendency does not appear to be associated with differences in social structure between the study species. Our findings from tuco-tucos differ from data in birds indicating that members of more gregarious species have greater vasotocin binding in the lateral septum (Goodson et al, 2006).…”

Section: Receptor Distributions and The Social Brainmentioning

confidence: 63%

Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco (Ctenomys haigi and Ctenomys sociabilis)

Beery

Lacey

Francis

2008

J of Comparative Neurology

127

123

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The neuropeptides oxytocin and vasopressin and their receptors have been implicated in elements of mammalian social behavior such as attachment to mates and offspring, but their potential role in mediating other types of social relationships remains largely unknown. We performed receptor autoradiography to assess whether forebrain oxytocin receptor (OTR) or vasopressin V1a receptor (V1aR) distributions differed with social structure in two closely related and ecologically similar species of South American rodents, the colonial tuco-tuco (Ctenomys sociabilis) and the Patagonian tuco-tuco (Ctenomys haigi). Long-term field studies have revealed that C. haigi is solitary, whereas C. sociabilis is social and provides a model of female-based group living. Our analyses revealed marked differences in OTR and V1aR distributions between these species. For example, only C. sociabilis had OTR binding in the piriform cortex and thalamus and V1aR binding in the olfactory bulbs. In contrast, C. haigi exhibited dramatically higher levels of OTR binding throughout the lateral septum and hippocampus. More generally, the group-living C. sociabilis exhibited a pattern of nucleus accumbens OTR and ventral pallidum V1aR binding different from that associated with the formation of opposite-sex pair bonds in microtine rodents. Higher binding in the central nucleus of the amygdala of C. sociabilis was consistent with the hypothesis that formation of social groups in C. sociabilis may be facilitated by reduced social anxiety. Low OTR binding in the lateral septum might also be a permissive factor for group living in C. sociabilis. Future studies will expand on these analyses to explore interspecific differences in ctenomyid receptor binding patterns in a phylogenetic context.

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“…Furthermore, intraseptal infusions of the reference antidepressant imipramine produced antidepressant-like effects in the forced-swimming test in rats (Estrada-Camarena et al, 2002), as is the case with 5-HT 1A receptor ligands (Schreiber and De Vry, 1993), confirming that the lateral septum mediates the behavioral effects of antidepressants. Concerning vasopressinergic tone, it has also been reported that the release of the peptide in the septum modulates social memory (Dantzer et al, 1988), aggressive (Everts et al, 1997), and anxiety-related behaviors in rats (Liebsch et al, 1996). Furthermore, these authors and others (Landgraf et al, 1995) have shown that the intraseptal application of nonselective V 1 receptor antagonists or V 1a receptor antisense produces anxiolytic-like effects in the elevated plus-maze in rats.…”

Section: Introductionmentioning

confidence: 90%

Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

Stemmelin

Lukovic

Salomé

et al. 2004

Neuropsychopharmacol

106

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Previous experiments with the first selective nonpeptide vasopressin V 1b receptor antagonist SSR149415 ((2S, 4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide) have shown that the drug elicits anxiolytic-and antidepressant-like effects following systemic administration. Extrahypothalamic V 1b receptors have been suggested to be involved in these effects as evidenced by the findings that hypophysectomized rats were still sensitive to the antistress action of SSR149415. The first objective of the present work aimed at locating V 1b receptors in the rat limbic brain using anti-V 1b receptor immunohistochemistry. The immunolabeling revealed high densities of V 1b receptors in the lateral septum, the amygdala, the bed nucleus of the stria terminalis, the hippocampal formation, and in several cortical areas. Since the lateral septum is well known to participate in the modulation of emotional processes, the second objective of this study went on to evaluate the behavioral effects of an infusion of SSR149415 into the lateral septum and to determine whether its behavioral effects are mediated by this structure. Animals were tested in models classically used for the screening of anxiolytics (ie the punished drinking and elevated plusmaze tests) and antidepressants (ie the forced-swimming test). Bilateral intraseptal infusion of SSR149415 (10 and 100 ng) produced a decrease in immobility time in the forced-swimming test, indicating antidepressant-like effects. In contrast, the behavior of rats in the punished drinking procedure or in the elevated plus-maze test was not modified by intraseptal infusion of SSR149415. These findings suggest that V 1b receptors located in the lateral septum participate in the antidepressant-but not the anxiolytic-like action of SSR149415 in rats.

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Differential Lateral Septal Vasopressin in Wild-type Rats: Correlation with Aggression

Cited by 101 publications

References 42 publications

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco (Ctenomys haigi and Ctenomys sociabilis)

Evidence that the Lateral Septum is Involved in the Antidepressant-Like Effects of the Vasopressin V1b Receptor Antagonist, SSR149415

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