Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

Li, Jingjing; Xu, Yajuan; Sun, Zongzong; Cai, Yanjun; Wang, Biao; Zhang, Miao; Ban, Yanjie; Hou, Xiaofeng; Hao, Yingqi; Ouyang, Qi; Wu, Bo; Wang, Mengqi; Wang, Wentao

doi:10.1038/s41598-021-99252-6

Cited by 14 publications

(18 citation statements)

References 34 publications

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“… 32 , 38 The plasma of pregnant women with subclinical hypothyroidism demonstrates several downregulated PE-like metabolites. 39 Consistent with the findings of previous studies, patients with thyroid dysfunction exhibited a decreasing trend of DG and PE metabolites and an increasing trend of PA metabolites in the serum; however, the exact action mechanism remains to be explored in depth. In addition, our findings reveal that the abovementioned lipid metabolites are closely associated with the GPL metabolism.…”

Section: Discussionsupporting

confidence: 88%

“…Reportedly, TSH can increase PA accumulation, thereby affecting thyroid metabolism . Phosphatidylethanolamine (PE), the most abundant phospholipid class in mammalian cells, exhibits significant changes during the progression of numerous diseases. , The plasma of pregnant women with subclinical hypothyroidism demonstrates several downregulated PE-like metabolites . Consistent with the findings of previous studies, patients with thyroid dysfunction exhibited a decreasing trend of DG and PE metabolites and an increasing trend of PA metabolites in the serum; however, the exact action mechanism remains to be explored in depth.…”

Section: Discussionmentioning

confidence: 55%

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Serum Lipidomic Analysis Reveals Biomarkers and Metabolic Pathways of Thyroid Dysfunction

et al. 2023

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Abnormal thyroid hormone secretion is the most important feature of hypothyroidism and plays an important role in lipid metabolism. However, their connection has not been clearly established. This study aimed to identify the serum biomarkers and metabolic pathways associated with hyperthyroidism and hypothyroidism. The study enrolled discovery and validation sets of 175 and 300 participants, respectively, to identify and validate the serum biomarkers of hyperthyroidism and hypothyroidism via ultrahigh performance liquid chromatography−quadrupole time-of-flight mass spectrometry lipidomics through univariate and multivariate analyses. Eight and six biomarkers were identified for hyperthyroidism and hypothyroidism, respectively. Spearman correlation analysis was used to assess the correlation between the biomarkers and thyroid dysfunction indicators; subsequently, metabolic pathway and network analyses were performed for these biomarkers. Most biomarkers exhibited significant correlation with thyroid dysfunction indicators, mainly being enriched in the glycerophospholipid (GPL) metabolism. The diagnostic accuracies of the biomarkers and biomarker panels were assessed via receiver operating characteristic curve analysis. All the biomarkers demonstrated good diagnostic performance, and the hyperthyroidism and hypothyroidism biomarker panels reached an area under the curve value of 1.000. The results were validated using the validation set. Therefore, our findings revealed that thyroid dysfunction primarily affects the human metabolism via the GPL metabolism, thus providing a theoretical basis for the clinical prevention and control of thyroid dysfunction.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 55%

Serum Lipidomic Analysis Reveals Biomarkers and Metabolic Pathways of Thyroid Dysfunction

et al. 2023

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“…A single-center retrospective study showed that HDL and LDL levels in the SCH group were significantly lower than those in the control group in the second and third trimesters of pregnancy. Li et al (25) found that 143 lipid molecules were expressed differently between the SCH and control groups. A study (26) about fatty acids and SCH showed that there was a correlation between serum fatty acid composition and pregnant Chinese women with SCH during the second and third trimesters of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Untreated thyroid autoantibody-negative SCH increases the risk of spontaneous abortions

Yuan

Sun

Zhao

et al. 2022

Endocrine Connections

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Background: Numerous studies have found that subclinical hypothyroidism (SCH) may increase the adverse pregnancy outcomes; however, the benefit of levothyroxine (LT4) treatment remains controversial.Therefore, the primary goal of this study was to investigate the correlation between thyroid autoantibodies negative-SCH with or without LT4 treatment and adverse pregnancy outcomes. Methods: 1344 women involved the study according the inclusion and exclusion criteria. Assays for thyroid stimulating hormone (TSH), free thyroxine (FT4), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TGAb) and laboratory indicators were performed. The participants were divided into the euthyroid group (n = 1250) and the SCH group(n=94). The SCH group was further divided into LT4 group (n =40) and non-LT4 group(n=54). The laboratory indicators and pregnancy outcomes were evaluated during follow-ups. Results: There were no significant differences in lipid profile and homocysteine levels between ET and SCH group in the first and third trimester of pregnancy (P<0.05). After adjusting the confounding factors, the non-LT4 group was a risk factor for spontaneous abortion (OR: 3.141, 95% CI: 1.060-9.302). Survival analysis showed that the time of abortion was different between the ET group and SCH group (Log-rank P=0.042). The spontaneous abortion of SCH, especially non-LT4 group mainly occurred in the first trimester of pregnancy. Conclusions: Thyroid autoantibody negative-SCH seems to be associated with increased risk of spontaneous abortions during first trimester of pregnancy. LT4 therapy in this patient population might be beneficial to reduce adverse pregnancy outcomes.

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“…the decrease in the number of LDL receptors in the serum of nonpregnant hypothyroidism patients reduced the LDL clearance rate, resulting in an increase in LDL and ApoB levels ( Jung et al., 2017 ). Our previous studies on lipid metabolism ( Li et al., 2021 ) found that the infectious pathway of pathogenic Escherichia coli was significantly higher in the disease group than in the normal group, which may be related to the increased level of phosphatidylethanolamine (PE) in hypothyroidism patients during pregnancy. And PE can maintain the stability of the cell membrane, affect the function of membrane proteins, and stimulate the occurrence of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy

Hao

Xu²,

Ban³

et al. 2022

Front. Cell. Infect. Microbiol.

Self Cite

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ObjectiveTo explore the effect of probiotics combined with prebiotics on clinical hypothyroidism during pregnancy combined with small intestinal bacterial overgrowth.Methods(1) In total, 441 pregnant women were included in this study. A total of 231 patients with clinical hypothyroidism during the second trimester of pregnancy and 210 normal pregnant women were enrolled in the lactulose methane-hydrogen breath test. The positive rate of intestinal bacterial overgrowth (SIBO), gastrointestinal symptoms, thyroid function and inflammatory factors were compared between the two groups by chi-square test and two independent sample t-test. (2) SIBO-positive patients in the clinical hypothyroidism group during pregnancy (n=112) were treated with probiotics combined with prebiotics based on conventional levothyroxine sodium tablets treatment. The changes in the methane-hydrogen breath test, gastrointestinal symptoms, thyroid function and inflammatory factors were compared before treatment (G0) and 21 days after treatment (G21) by chi-square test and paired sample t test.Results(1) The positive rates of SIBO in pregnant women in the clinical hypothyroidism group and control group were 48.5% and 24.8%, respectively. (2) The incidence of abdominal distention and constipation in the clinical hypothyroidism group was significantly higher than that in the control group, and the risk of abdominal distention and constipation in SIBO-positive pregnant women was higher than that in SIBO-negative pregnant women. (3) The serum levels of hypersensitive C-reactive protein (hsCRP), IL-10, IL-6, TNF-α, low-density lipoprotein (LDL), total cholesterol (TC), free fatty acids (FFAs) and apolipoprotein B (ApoB) in the hypothyroidism group during pregnancy were higher than those in the control group. (4) After 21 days of probiotics combined with prebiotics, the incidence of pure methane positivity in the methane-hydrogen breath test in the G21 group was significantly reduced, and the average abundance of hydrogen and methane at each time point in the G21 group was lower than that in the G0 group. (5) The incidence of constipation in the G21 group was significantly lower than before treatment. (6) The levels of serum TSH, hsCRP, IL-6, TNF-α, TC and LDL in pregnant women after probiotics combined with prebiotics were lower than those before treatment.ConclusionProbiotics combined with prebiotics are effective in the treatment of pregnant patients with clinical hypothyroidism complicated with SIBO, providing a new idea to treat pregnant patients with clinical hypothyroidism complicated with SIBO.

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Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

Cited by 14 publications

References 34 publications

Serum Lipidomic Analysis Reveals Biomarkers and Metabolic Pathways of Thyroid Dysfunction

Serum Lipidomic Analysis Reveals Biomarkers and Metabolic Pathways of Thyroid Dysfunction

Untreated thyroid autoantibody-negative SCH increases the risk of spontaneous abortions

Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy

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