Differential low uptake of free vitamin D supplements in preterm infants: the Quebec experience

Fatani, Tarah; Sharma, Atul; Weiler, Hope A.; Sheehy, Odile; Berard, Aurélie; Rodd, Celia

doi:10.1186/s12887-014-0291-6

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…This suggests that vitamin D supplementation is also required from birth in LMPT infants. A study performed in Canada showed that the chance of receiving vitamin supplementation after discharge is lower in the LPT population than in preterm infants born before 34 weeks of gestation (131). Targeting LPT infants could improve vitamin D intake in these infants who are at high risk of vitamin deficiency.…”

Section: Estimation Of Nutritional Requirementsmentioning

confidence: 99%

Feeding the Late and Moderately Preterm Infant

Lapillonne

Bronský

Campoy

et al. 2019

J. pediatr. gastroenterol. nutr.

114

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Objectives-This report presents 2008 data on U.S. births according to a wide variety of characteristics. Data are presented for maternal demographic characteristics including age, live-birth order, race and Hispanic origin, marital status, attendant at birth, method of delivery, and infant characteristics (period of gestation, birthweight, and multiple births). Birth and fertility rates by age, live-birth order, race and Hispanic origin, and marital status also are presented. Selected data by mother's state of residence are shown, as well as data on age of father. Trends in fertility patterns and maternal and infant characteristics are described and interpreted. Methods-Descriptive tabulations of data reported on the birth certificates of the 4.25 million births that occurred in 2008 are pre sented. Denominators for population-based rates are postcensal esti mates derived from the U.S. 2000 census. Results-A total of 4,247,694 births were registered in the United States in 2008, 2 percent less than in 2007. The general fertility rate declined 1 percent to 68.6 per 1,000. The teenage birth rate declined 2 percent to 41.5 per 1,000. Birth rates for women aged 20 to 39 years were down 1-3 percent, whereas the birth rate for women aged 40-44 rose to the highest level reported in more than 40 years. The total fertility rate declined 2 percent to 2,084.5 per 1,000 women. All mea sures of unmarried childbearing reached record levels-40.6 percent of births were to unmarried women in 2008. The cesarean delivery rate rose again to 32.3 percent. The preterm birth rate declined for the second consecutive year to 12.3 percent; the low birthweight rate was down very slightly. The twin birth rate increased 1 percent to 32.6 per 1,000; the triplet and higher-order multiple birth rate was stable.

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Section: Estimation Of Nutritional Requirementsmentioning

confidence: 99%

Feeding the Late and Moderately Preterm Infant

Lapillonne

Bronský

Campoy

et al. 2019

J. pediatr. gastroenterol. nutr.

114

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“…Moreover, vitD supplementation is routinely offered for free in Quebec pharmacies for premature infants. Pharmacy records showed a low utilization of vitD supplements by this vulnerable high-risk group for deficiency [18]. Similarly, a meta-analysis of 18 RCTs on vitD supplementation in adults reported low compliance [70].…”

Section: Discussionmentioning

confidence: 99%

“…One of the major obstacles contributing to vitD deficiency is the lack of foods naturally rich in vitD. In addition, mass supplementation (Table 1) is less efficacious compared with food fortification because of its higher cost, and insignificant advertisements make mass supplementation difficult to implement or sustain worldwide even among high-risk groups such as premature infants [18][19][20]. Furthermore, the mild symptoms and subtle signs of vitD deficiency might discourage children and adolescents from taking daily supplements for a long period of time [21].…”

Section: Introductionmentioning

confidence: 99%

The impact of vitamin D food fortification and health outcomes in children: a systematic review and meta-regression

et al. 2020

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Objective: Vitamin D (vitD) deficiency is a global childhood health problem. Food fortification is a promising strategy to curb vitD deficiency. We aimed to assess the effectiveness of utilizing vitD fortification in staple foods to improve 25hydroxyvitamin D (25(OH)D) concentration and to reduce the prevalence of vitD deficiency among healthy children. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the use of vitD fortified food products compared to no fortification among healthy children aged 1-18 years old. We searched Medline, Embase, Global Health, and Cochrane (CENTRAL) databases from database inception until May 2019. Independently, six reviewers in pairs screened titles and abstracts, assessed the full text for eligibility, and performed data extraction and quality assessment. The primary outcome is the impact of fortification on 25(OH)D concentration. The secondary outcomes included the impact of fortification on the prevalence of vitD deficiency, school performance, cognitive function, school absences, infection rate, hospital admission length, and compliance with fortified food product consumption. Results: We identified 2229 articles. After assessing eligibility, 20 RCTs met the inclusion criteria. The eligible RCTs assessed the fortification of milk, cereal, juice, bread, yogurt, and cheese compared with no fortification. All RCTs, except for three, had a low risk of bias. Food fortification improved 25(OH)D concentration by a mean difference (MD) of 15.51 nmol/L (95% confidence interval (CI) 6.28, 24.74; I 2 = 99%), which resulted in a mean increase of 3 nmol/l for every 100 IU of vitD, when adjusted for baseline 25(OH)D concentration and country latitude. Additionally, the prevalence of vitD deficiency decreased by a risk ratio of 0.53 (95% CI 0.41, 0.69; I 2 = 95%), and cognitive function improved by a MD of 1.22 intelligence quotient (IQ) points (95% CI 0.65, 1.79; I 2 = 0%). The overall evidence quality was high. Conclusion: VitD food fortification is an effective way to improve 25(OH)D concentration, prevent vitD deficiency, and improve IQ levels. Systematic review registration: PROSPERO CRD42017057631

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“…Paediatrics & Child Health, 2019, 179-184 doi: 10.1093/pch/pxy105 Original Article Advance Access publication 13 August 2018 supplements should be provided to breast-fed infants (5). Formula fed infants may also be at risk if they do not consume a litre of formula per day (400 IU vitamin D/litre) and may require supplementation (6)(7)(8). Canada practices vitamin D fortification of commercial milk and margarine to reduce the incidence of rickets.…”

mentioning

confidence: 99%

A closer look at rickets and vitamin D deficiency in Manitoba: The tip of the iceberg

Lautatzis

Sharma

Rodd

2018

Paediatrics &Amp; Child Health

Self Cite

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Objectives: Vitamin D deficiency rickets remains a problem in Canada. Our primary objective was to determine the annual incidence of rickets and/or early vitamin D deficiency in Manitoba. Secondarily, we investigated if there was an increase in the annual incidence. Methods: A retrospective chart review was undertaken to identify cases in our catchment area from 2003 to 2015. Data sources included endocrine and hospital charts and radiology reports. Early vitamin D deficiency was determined by review of all 25(OH)D tests from 2011 to 2015. Values less than 30 nmol/L with an elevated bone marker prompted a chart review in children under 7 years. Results: We identified 46 cases of rickets and 68 with early vitamin D deficiency. For Manitoba, the annual incidence of rickets was 8.2 cases per 100,000 in infants, and 1.6 per 100,000 in children aged 1 to 7 years. Those with early vitamin D deficiency had annual incidences of 2.7 per 100,000 infants and 9.9 per 100,000 Manitoban children. No temporal trends were noted for either. For both disorders, most cases were from northern or rural locales; about 50% were of self-declared Indigenous or Inuit heritage, and the majority (>75%) of children were from families with high material deprivation using area-based socioeconomic measures. Conclusion: Despite several decades of preventative efforts, the incidence of rickets was comparable to previous Canadian reports, particularly in infants. Greater education across the lifespan and engagement with communities and public health agencies will be needed to reduce the high incidence of this preventable disease.

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Differential low uptake of free vitamin D supplements in preterm infants: the Quebec experience

Cited by 4 publications

References 23 publications

Feeding the Late and Moderately Preterm Infant

Feeding the Late and Moderately Preterm Infant

The impact of vitamin D food fortification and health outcomes in children: a systematic review and meta-regression

A closer look at rickets and vitamin D deficiency in Manitoba: The tip of the iceberg

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