Differential Mechanism of Action of 3,4’,7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells

Ashraf, Aisha; Afroze, Syeda H.; Yamauchi, Kosei; Zawieja, David C.; Keuhl, Thomas J.; Erlandson, Laura Weiser; Uddin, Mohammad Nasir

doi:10.21873/anticanres.12835

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…It also raised the Bax/Bcl‐2 ratio in SK‐OV‐3 and CRL‐1978 cell lines but inhibited it in CRL‐11731 cell line. Therefore, 34′7TMQ induced cell death through different pathways in ovarian cancer cell lines (Ashraf et al, 2018). Angiogenesis is one of the important factors in the proliferation of cancer cells.…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

“…Furthermore, it seems that QUR can modulate the production of transforming growth factor β1 (TGFβ1) resulting in the inhibition of human ovarian cancer cells growth (Scambia et al, 1994). However, another study reported that 3,4 0 ,7-O-trimethylquercetin, a derivative of QUR, suppressed the migration and invasion of ovarian cancer cells without affecting cell proliferation (Ashraf et al, 2018).…”

Section: Qur and Ovarian Cancermentioning

confidence: 99%

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Overview of biological effects of Quercetin on ovary

Rashidi

Khosravizadeh

Talebi

et al. 2020

Phytotherapy Research

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Over the last few decades, using natural products has been increased to treat different diseases. Today, great attention has been pointed toward the usage of natural products such as flavonoids, especially Quercetin (QUR), in the treatment of diseases. QUR as a natural antioxidant has been traditionally used to prevent or treat a variety of diseases such as cancer, cardiovascular disease, polycystic ovary syndrome (PCOS), obesity, chronic inflammation, and reproductive system dysfunction. Several studies demonstrated that QUR acts as an anti‐inflammatory, anti‐apoptotic, antioxidant, and anticancer agent. With this in view, in this study, we intended to describe an overview of the biological effects of QUR on the ovary. QUR improves the quality of oocytes and embryos. It affects the proliferation and apoptosis and decreases the oxidative stress in granulosa cells (GCs). Furthermore, QUR can be used as a complementary and alternative therapy in ovarian cancer and it has beneficial effects in the treatment of PCOS patients. It seems that QUR as a supplementary factor has different activities for the treatment of different disorders and it also has bidirectional activities. However, further investigations are needed for understanding the efficacy of QUR in the treatment and improvement of gynecological patients.

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Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

Section: Qur and Ovarian Cancermentioning

confidence: 99%

Overview of biological effects of Quercetin on ovary

Rashidi

Khosravizadeh

Talebi

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Actually, despite the previous belief about the general increase in NF-κB expression in cancer, recent reports showed that tumors differentially express specific subunits of the NF-κB pathway, suggesting the possible existence of a finely regulated tuning towards apoptosis by different flavonoids in different target cells [ 107 ]. Actually, 3,4’,7-O-trimethyl quercetin, a derivative of quercetin, induces apoptosis in ovarian cancer cell lines CRL-1978, CRL-11731, SK-OV-3, following three different target pathways, depending on the cell type [ 108 ].…”

Section: Insights On the Role Of Flavonoids In Cancermentioning

confidence: 99%

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

Chirumbolo

Bjørklund

Lysiuk

et al. 2018

IJMS

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The role of phytochemicals as potential prodrugs or therapeutic substances against tumors has come in the spotlight in the very recent years, thanks to the huge mass of encouraging and promising results of the in vitro activity of many phenolic compounds from plant raw extracts against many cancer cell lines. Little but important evidence can be retrieved from the clinical and nutritional scientific literature, where flavonoids are investigated as major pro-apoptotic and anti-metastatic compounds. However, the actual role of these compounds in cancer is still far to be fully elucidated. Many of these phytochemicals act in a pleiotropic and poorly specific manner, but, more importantly, they are able to tune the reactive oxygen species (ROS) signaling to activate a survival or a pro-autophagic and pro-apoptosis mechanism, depending on the oxidative stress-responsive endowment of the targeted cell. This review will try to focus on this issue.

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Natural products targeting the MAPK-signaling pathway in cancer: overview

Shi,

Liu,

et al. 2024

J Cancer Res Clin Oncol

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Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these natural products are elucidated, and comprehensive information is provided on their potential use in cancer therapy. Methods Using the PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant chemical components”, and “MAPK-signaling pathway”. We also screened for compounds with well-defined structures that targeting the MAPK-signaling pathway and have anti-cancer effects. We used Kingdraw software and Adobe Photoshop software to draw the chemical compound structural diagrams. Results A total of 131 papers were searched, from which 85 compounds with well-defined structures were selected. These compounds have clear mechanisms for targeting cancer treatment and are mainly related to the MAPK-signaling pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, and juglone. These chemical components are classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, and quinones. Conclusions Certain MAPK pathway inhibitors have been used for clinical treatment. However, the clinical feedback has not been promising because of genomic instability, drug resistance, and side effects. Natural products have few side effects, good medicinal efficacy, a wide range of sources, individual heterogeneity of biological activity, and are capable of treating disease from multiple targets. These characteristics make natural products promising drugs for cancer treatment.

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Differential Mechanism of Action of 3,4’,7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells

Abstract: 34'7TMQ induced apoptosis in three types of cancer cell lines but it appears to have a different mechanism of action in each cell line.

Cited by 10 publications

References 20 publications

Overview of biological effects of Quercetin on ovary

Overview of biological effects of Quercetin on ovary

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

Natural products targeting the MAPK-signaling pathway in cancer: overview

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