Differential Metabolic Activity in the Striosome and Matrix Compartments of the Rat Striatum during Natural Behaviors

Brown, Lucy L.; Feldman, Samuel; Smith, Diane; Cavanaugh, James R.; Ackermann, Robert F.; Graybiel, Ann M.

doi:10.1523/jneurosci.22-01-00305.2002

Cited by 61 publications

(42 citation statements)

References 76 publications

(99 reference statements)

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“…6 A, B). Importantly, as in other rodent species (Pert et al, 1976;Herkenham and Pert, 1981;Gerfen and Young, 1988;Mansour et al, 1994;Brown et al, 2002;Crittenden and Graybiel, 2011), a clear patch-matrix pattern of -opioid receptor distribution can be seen throughout the striatum (Fig. 6 A-C).…”

Section: -Opioid and -Opioid Receptor Binding Patterns In Prairie Volessupporting

confidence: 69%

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

et al. 2012

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The prairie vole is a socially monogamous species in which breeder pairs typically show strong and selective pair bonds. The establishment of a pair bond is associated with a behavioral transition from general affiliation to aggressive rejection of novel conspecifics. This "selective aggression" is indicative of mate guarding that is necessary to maintain the initial pair bond. In the laboratory, the neurobiology of this behavior is studied using resident-intruder testing. Although it is well established that social behaviors in other species are mediated by endogenous opioid systems, opiate regulation of pair bond maintenance has never been studied. Here, we used resident-intruder testing to determine whether endogenous opioids within brain motivational circuitry mediate selective aggression in prairie voles. We first show that peripheral blockade of -opioid receptors with the antagonist norbinaltorphimine (nor-BNI; 100 mg/kg), but not with the preferential -opioid receptor antagonist naloxone (1, 10, or 30 mg/kg), decreased selective aggression in males. We then provide the first comprehensive characterization of -and -opioid receptors in the prairie vole brain. Finally, we demonstrate that blockade of -opioid receptors (500 ng nor-BNI) within the nucleus accumbens (NAc) shell abolishes selective aggression in both sexes, but blockade of these receptors within the NAc core enhances this behavior specifically in females. Blockade of -opioid receptors within the ventral pallidum or -opioid receptors with the specific -opioid receptor antagonist H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-PenThr-NH2 (1 ng CTAP) within the NAc shell had no effect in either sex. Thus, -opioid receptors within the NAc shell mediate aversive social motivation that is critical for pair bond maintenance.

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Section: -Opioid and -Opioid Receptor Binding Patterns In Prairie Volessupporting

confidence: 69%

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

et al. 2012

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“…62,63 Our data do not appear to rule out any particular cause for lacunar infarcts, or imply that a functional supply from an anastomotic arteriole may compensate for occlusion of an adjacent arteriole. Emboli reaching capillary beds or distal third-order arterioles leading to capillary beds would still cause lacunar infarction because most anastomoses do not continue into the capillary beds or are not large enough to compensate.…”

Section: Anastomosismentioning

confidence: 54%

Tertiary microvascular territories define lacunar infarcts in the basal ganglia

Feekes

Hsu

Chaloupka

et al. 2005

Annals of Neurology

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Lacunar infarcts are commonly found in the basal ganglia, though little is known about the organization of small-scale microvascular territories that presumably subtend lacunae. We investigated microvascular territories of the lenticulostriate arteries, the recurrent artery of Heubner, the anterior choroidal artery, and striate branches of the anterior cerebral and anterior communicating arteries in perfusion-fixed human brains by simultaneous injection of fluorescent dyes and a radio-opaque substance in 5% gelatin. Territories were defined by ultraviolet illumination of dye and high-resolution mammography of radio-opaque substance. Brains were sectioned coplanar with the Talairach proportional grid system and vascular data were plotted, allowing for application to any human brain. The data suggest first that the lenticulostriate artery, recurrent artery of Heubner, and anterior choroidal artery supply distinct territories of the basal ganglia with minimal overlap and sparse anastomoses between major penetrating vessels. Individual territories are spatially consistent across brains and match the extent of major/minor infarcts. Second, branching patterns of parental, second-, and third-order vessels leading to circumscribed terminal vascular beds could account structurally for "lacunar" infarcts.

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“…An example of such structures could be striosomes, which are a neurochemically distinct compartment in the striatum [11,15]. Striosomes have different electrophysiology [54] and metabolic activity [4] than the surrounding matrix. However, the authors are unaware of permeability measurements within striosomes.…”

Section: Nanoparticle Distribution Volumementioning

confidence: 99%

Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles

et al. 2007

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This study investigates methods of manipulating the brain extracellular matrix (ECM) to enhance the penetration of nanoparticle drug carriers in convection-enhanced delivery (CED). A probe was fabricated with two independent microfluidic channels to infuse, either simultaneously or sequentially, nanoparticles and ECM-modifying agents. Infusions were performed in the striatum of the normal rat brain. Monodisperse polystyrene particles with a diameter of 54 nm were used as a model nanoparticle system. Because the size of these particles is comparable to the effective pore size of the ECM, their transport may be significantly hindered compared with the transport of low molecular weight molecules. To enhance the transport of the infused nanoparticles, we attempted to increase the effective pore size of the ECM by two methods: dilating the extracellular space and degrading selected constituents of the ECM. Two methods of dilating the extracellular space were investigated: co-infusion of nanoparticles and a hyperosmolar solution of mannitol, and pre-infusion of an isotonic buffer solution followed by infusion of nanoparticles. These treatments resulted in an increase in the nanoparticle distribution volume of 50% and 123%, respectively. To degrade hyaluronan, a primary structural component of the brain ECM, a pre-infusion of hyaluronidase (20,000 U/mL) was followed after 30 min by infusion of nanoparticles. This treatment resulted in an increase in the nanoparticle distribution of 64%. Our results suggest that both dilation and enzymatic digestion can be incorporated into CED protocols to enhance nanoparticle penetration.

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Differential Metabolic Activity in the Striosome and Matrix Compartments of the Rat Striatum during Natural Behaviors

Cited by 61 publications

References 76 publications

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

Tertiary microvascular territories define lacunar infarcts in the basal ganglia

Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles

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