Differential metabolism of benzo[α]pyrene in vitro by human placental tissues exposed to active maternal cigarette smoke

Sanyal, Mrinal K.; Li, You Lan

doi:10.1002/bdrb.20102

Cited by 26 publications

(13 citation statements)

References 29 publications

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“…In some studies, placental microsomes from smokers and nonsmokers have been compared. Interindividual variation in response to benzo-[a]-pyrene or in the ability to detoxify have been found to be high (Sanyal and Li, 2007).…”

Section: Placentamentioning

confidence: 99%

In vitro assessment of reproductive toxicity of tobacco smoke and its constituents

Talbot

2008

Birth Defects Research Pt C

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Epidemiological studies have repeatedly shown that reproductive processes in pregnant women are adversely affected by exposure to cigarette smoke. The potential reproductive targets of smoke during pregnancy include the ovaries, oviducts, uterus, placenta, umbilical cord, and embryo/fetus. In vitro methods for studying the effects of smoke and its individual components have been developed and applied to each of these reproductive targets. In vitro assays have been useful in determining the biological processes that are affected in the reproductive organs and in identifying the cellular and molecular targets of smoke in each organ. In vitro methods have also been used to study the mechanism of action of smoke constituents, such as nicotine, on specific processes in reproductive organs and to screen smoke solutions to identify the molecules that affect reproduction. In general, data collected in vitro have confirmed, extended, and helped explain what has been learned from epidemiological studies. This review summarizes some of the in vitro assays that have been used to study cigarette smoke's effect on the nonpregnant and pregnant female reproductive tract and spotlights examples of their applications.

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Section: Placentamentioning

confidence: 99%

In vitro assessment of reproductive toxicity of tobacco smoke and its constituents

Talbot

2008

Birth Defects Research Pt C

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“…We observed small positive associations with some CHD phenotypic subtypes, although effect measure estimates were generally imprecise. Future investigations could be improved by working with larger sample sizes in populations with higher potential for PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism, because ongoing research suggests that genetic susceptibility in combination with environmental exposures predisposes individuals to the greatest risk (Whyatt et al, 1998; Wassenberg and Di Giulio, 2004; Wassenberg et al, 2005; Shimada, 2006; Sanyal and Li, 2007). …”

Section: Discussionmentioning

confidence: 99%

Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Lupo

Symanski

Langlois

et al. 2012

Birth Defects Research

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BACKGROUND There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58–1.67), septal defects (AOR, 1.28; 95% CI, 0.86–1.90), or with any isolated CHD subtype. CONCLUSIONS Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.

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“…The placenta expresses markedly augmented PAHs metabolism capabilities in response to cigarette smoke exposure during pregnancy, indicating that placental metabolism may be an important mediator of adverse effects induced by exposure to tobacco smoke, 27 resulting in a lower production of PAH-DNA adducts in the fetus. However, PAHs, such as B[a]P, readily cross the placenta, and PAH-DNA adducts are easily detectable in fetuses and neonates because they are particularly prone to form and maintain adducts because detoxification and DNA repair capabilities are reduced during fetal development.…”

Section: Discussionmentioning

confidence: 99%

Are Benzo[a]pyrene–DNA Adducts an Accurate Biomarker of Long-Term In Utero Exposure to Smoking?

Stéphan-Blanchard¹,

Chardon²,

Telliez³

et al. 2011

Therapeutic Drug Monitoring

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This preliminary study suggests that B[a]P-DNA adducts are reliable biomarkers for the screening of long-term in utero exposure to smoking and are accurate when compared with maternal self-reported levels of active smoking. Detection of B[a]P-DNA adducts in neonates could provide a useful, noninvasive tool in clinical risk assessment studies but would benefit from further confirmation with another validated biomarker.

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Differential metabolism of benzo[α]pyrene in vitro by human placental tissues exposed to active maternal cigarette smoke

Cited by 26 publications

References 29 publications

In vitro assessment of reproductive toxicity of tobacco smoke and its constituents

In vitro assessment of reproductive toxicity of tobacco smoke and its constituents

Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Are Benzo[a]pyrene–DNA Adducts an Accurate Biomarker of Long-Term In Utero Exposure to Smoking?

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