Differential metabolism of choline supplements in adult volunteers

Böckmann, Katrin; Franz, Axel; Minarski, Michaela; Shunova, Anna; Maiwald, Christian; Schwarz, Julian; Groß, Maximilian; Poets, Christian F.; Bernhard, Wolfgang

doi:10.1007/s00394-021-02637-6

Cited by 17 publications

(19 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Die Plasmahalbwertszeit von Cholin (und Betain) ist sehr kurz (ca.1h), aber auch Ptd'Cho wird schnell ins Plasma sezerniert und von Organen aufgenommen [7,15]. Die Leber versorgt über das Ptd'Cho der Lipoproteine sehr geringer Dichte (VLDL) Gehirn und Lunge mit Cholin, ARA und DHA [8,25]. Im Cholinmangel hingegen wird Ptd'Cho von der Lunge zur Leber transportiert, um deren Funktion aufrechtzuerhalten [26].…”

Section: Turnover Von Cholin Und Seinen Syntheseproduktenunclassified

“…Die stärkste TMAO-Erhöhung findet sich bei Cholinbitartrat. Das ist bei ansonsten asymptomatischer bakterieller Fehlbesiedlung des Dünndarms relevant 8 .…”

Section: Tmao-unterschiede Im Bakteriellen Abbau Unterschiedlicher ...unclassified

“…Sie enthalten meist unphysiologische Cholinsalze, die – auch ohne Fehlbesiedlung des Dünndarms – zu erhöhter bakterieller Bildung von Trimethylamin führen, gefolgt von dessen Oxidation zu Trimethylaminoxid (TMAO) in der Leber. TMAO-Bildung findet bei physiologischen Cholinkomponenten von Lebensmitteln weniger oder gar nicht statt 8 9 .…”

Section: Introductionunclassified

“…Daraus ergibt sich ein verzögerter, ausgeglichenerer Anstieg des Plasmacholinspiegels[2,8,15]. Auch werden die Spaltprodukte (Lyso-Ptd'Cho) für die Bildung von Chylomikronen zu Ptd'Cho resynthetisiert, sodass Ptd'Cho und Lipide unter Umgehung der Leber direkt zu den Organen transportiert werden[8,19,25].Galle und Cholin-HomöostaseDie biliäre Sekretion von Ptd'Cho ist prioritär für den Leberstoffwechsel. Dabei werden täglich etwa 50 % des Ptd'Cho der Leber ins Duodenum sezerniert und wieder resorbiert.…”

unclassified

See 3 more Smart Citations

Die Bedeutung von Cholin für die Entwicklung von Säuglingen und Kindern

Bernhard¹,

Poets²,

Franz³

2022

Ernährung & Medizin

Self Cite

View full text Add to dashboard Cite

Cholin ist ein essenzieller Nährstoff mit wachstumsproportionalem Bedarf. Eine zu geringe Zufuhr, eine gestörte Wiederaufnahme bzw. fäkale Verluste durch Darmerkrankungen und bakterieller Abbau kann bei Kindern zu einem Cholinmangel führen, ebenso wie ein erhöhter Fettgehalt der Leber (Steatose). Bei Säuglingen liegt die Cholinzufuhr durch Formula häufig unter der durch Muttermilch und hat eine unphysiologische Zusammensetzung.

show abstract

Section: Turnover Von Cholin Und Seinen Syntheseproduktenunclassified

“…Die stärkste TMAO-Erhöhung findet sich bei Cholinbitartrat. Das ist bei ansonsten asymptomatischer bakterieller Fehlbesiedlung des Dünndarms relevant 8 .…”

Section: Tmao-unterschiede Im Bakteriellen Abbau Unterschiedlicher ...unclassified

Section: Introductionunclassified

unclassified

See 2 more Smart Citations

Die Bedeutung von Cholin für die Entwicklung von Säuglingen und Kindern

Bernhard¹,

Poets²,

Franz³

2022

Ernährung & Medizin

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to preterm birth, the high level of continuous active trans-placental choline supply is interrupted in a phase of exponential general and brain growth and development (24–32 week postmenstrual age). Moreover, the fetus is exposed to and swallows ⁓ 400 mL/d-amniotic fluid comprising ⁓ 90 µM choline compounds, mainly PC, choline, SPH and α -glycerophosphorylcholine (GPC) ([ 25 ] and unpublished own analyses).…”

Section: Introductionmentioning

confidence: 99%

Choline supplementation for preterm infants: metabolism of four Deuterium-labeled choline compounds

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Supply of choline is not guaranteed in current preterm infant nutrition. Choline serves in parenchyma formation by membrane phosphatidylcholine (PC), plasma transport of poly-unsaturated fatty acids (PUFA) via PC, and methylation processes via betaine. PUFA-PC concentrations are high in brain, liver and lung, and deficiency may result in developmental disorders. We compared different deuterated (D9-) choline components for kinetics of D9-choline, D9-betaine and D9-PC. Methods Prospective study (1/2021–12/2021) in 32 enterally fed preterm infants (28 0/7–32 0/7 weeks gestation). Patients were randomized to receive enterally a single dose of 2.7 mg/kg D9-choline-equivalent as D9-choline chloride, D9-phosphoryl-choline, D9-glycerophosphorylcholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-PC(D9-POPC), followed by blood sampling at 1 + 24 h or 12 + 60 h after administration. Plasma concentrations were analyzed by tandem mass spectrometry. Results are expressed as median (25th/75th percentile). Results At 1 h, plasma D9-choline was 1.8 (0.9/2.2) µmol/L, 1.3 (0.9/1.5) µmol/L and 1.2 (0.7/1.4) µmol/L for D9-choline chloride, D9-GPC and D9-phosphoryl-choline, respectively. D9-POPC did not result in plasma D9-choline. Plasma D9-betaine was maximal at 12 h, with lowest concentrations after D9-POPC. Maximum plasma D9-PC values at 12 h were the highest after D9-POPC (14.4 (9.1/18.9) µmol/L), compared to the other components (D9-choline chloride: 8.1 [5.6/9.9] µmol/L; D9-GPC: 8.4 (6.2/10.3) µmol/L; D9-phosphoryl-choline: 9.8 (8.6/14.5) µmol/L). Predominance of D9-PC comprising linoleic, rather than oleic acid, indicated fatty-acyl remodeling of administered D9-POPC prior to systemic delivery. Conclusion D9-Choline chloride, D9-GPC and D9-phosphoryl-choline equally increased plasma D9-choline and D9-betaine. D9-POPC shifted metabolism from D9-betaine to D9-PC. Combined supplementation of GPC and (PO) PC may be best suited to optimize choline supply in preterm infants. Due to fatty acid remodeling of (PO) PC during its assimilation, PUFA co-supplementation with (PO) PC may increase PUFA-delivery to critical organs. This study was registered (22.01.2020) at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502. Study registration This study was registered at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502.

show abstract

Different choline supplement metabolism in adults using deuterium labelling

et al. 2023

View full text Add to dashboard Cite

Background Choline deficiency leads to pathologies particularly of the liver, brain and lung. Adequate supply is important for preterm infants and patients with cystic fibrosis. We analysed the assimilation of four different enterally administered deuterium-labelled (D9-) choline supplements in adults. Methods Prospective randomised cross-over study (11/2020–1/2022) in six healthy men, receiving four single doses of 2.7 mg/kg D9-choline equivalent each in the form of D9-choline chloride, D9-phosphorylcholine, D9-alpha-glycerophosphocholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-glycero-3-phosphoryl-choline (D9-POPC), in randomised order 6 weeks apart. Plasma was obtained at baseline (t = − 0.1 h) and at 0.5 h to 7d after intake. Concentrations of D9-choline and its D9-labelled metabolites were analysed by tandem mass spectrometry. Results are shown as median and interquartile range. Results Maximum D9-choline and D9-betaine concentrations were reached latest after D9-POPC administration versus other components. D9-POPC and D9-phosphorylcholine resulted in lower D9-trimethylamine (D9-TMAO) formation. The AUCs (0-7d) of plasma D9-PC concentration showed highest values after administration of D9-POPC. D9-POPC appeared in plasma after fatty acid remodelling, predominantly as D9-1-palmitoyl-2-linoleyl-PC (D9-PLPC), confirming cleavage to 1-palmitoyl-lyso-D9-PC and re-acylation with linoleic acid as the most prominent alimentary unsaturated fatty acid. Conclusion There was a delayed increase in plasma D9-choline and D9-betaine after D9-POPC administration, with no differences in AUC over time. D9-POPC resulted in a higher AUC of D9-PC and virtually absent D9-TMAO levels. D9-POPC is remodelled according to enterocytic fatty acid availability. D9-POPC seems best suited as choline supplement to increase plasma PC concentrations, with PC as a carrier of choline and targeted fatty acid supply as required by organs. This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498, 22.01.2020. Study registration This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498.

show abstract

Differential metabolism of choline supplements in adult volunteers

Cited by 17 publications

References 36 publications

Die Bedeutung von Cholin für die Entwicklung von Säuglingen und Kindern

Die Bedeutung von Cholin für die Entwicklung von Säuglingen und Kindern

Choline supplementation for preterm infants: metabolism of four Deuterium-labeled choline compounds

Different choline supplement metabolism in adults using deuterium labelling

Contact Info

Product

Resources

About