Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes

Yu, Yeuni; Kim, Hyun‐Joo; Song, Jaemin; Kang, Junmo; Lee, Hansong; Park, Hae Ryoun; Kim, Yun Hak

doi:10.3389/fcimb.2022.1061125

Cited by 8 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study, which compared healthy controls both to periodontal disease patients and to diabetic patients with periodontal disease, showed that patients with periodontal disease had higher numbers of perio-pathogens (mostly pathogenic from the red group), but patients with diabetes and periodontal disease had higher numbers of periodontal pathogens which connected with other pathogens (orange group). Although no major diversity was found within the phyla of the pathogens, the authors suggested that the connection between the periodontal pathogens is the cause for the rapid progression of periodontal disease in diabetic patients [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Aizenbud,

Wilensky,

Almoznino

2023

IJMS

View full text Add to dashboard Cite

Periodontal disease is a complex and progressive chronic inflammatory condition that leads to the loss of alveolar bone and teeth. It has been associated with various systemic diseases, including diabetes mellitus and obesity, among others. Some of these conditions are part of the metabolic syndrome cluster, a group of interconnected systemic diseases that significantly raise the risk of cardiovascular diseases, diabetes mellitus, and stroke. The metabolic syndrome cluster encompasses central obesity, dyslipidemia, insulin resistance, and hypertension. In this review, our objective is to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster. By doing so, we aim to gain insights into the fundamental mechanisms that link each systemic condition with the metabolic syndrome. This deeper understanding of the interplay between these conditions and periodontal disease can pave the way for more effective treatments that take into account the broader impact of managing periodontal disease on the comprehensive treatment of systemic diseases, and vice versa.

show abstract

Section: Resultsmentioning

confidence: 99%

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Aizenbud,

Wilensky,

Almoznino

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Secretory Ig A makes up two-thirds of the Ig A class antibodies of the human body and causes opsonization and agglutination of microorganisms, has a bacteriostatic effect, prevents the adhesion of microorganisms to the epithelium, and neutralizes bacterial toxins [18,19,20,21]. The higher concentrations of Ig A observed in diabetic patients may be the result of an immune response to advanced glycation end products, which increase and accumulate due to persistently high blood glucose levels.…”

Section: Discussionmentioning

confidence: 99%

Features of Changes in Indicators of Local Immunity of the Oral Cavity and Blood Serum of Patients Against the Background of Generalized Periodontitis and Type 2 Diabetes Mellitus

Balitska,

Hasiuk,

Piasetska

et al. 2023

UESMS

View full text Add to dashboard Cite

Aim: to evaluate the nature of changes in innate humoral immunity in oral fluid and blood serum in patients with generalized periodontitis against the background of type 2 diabetes mellitus and in their combination. Materials and methods. We examined 68 patients with a clinically established diagnosis of type 2 diabetes mellitus (of which 32 were additionally diagnosed with chronic generalized periodontitis), who were divided into 4 groups. The content of the main classes of immunoglobulins Ig A, Ig G and Ig M in blood serum and oral fluid was determined by radial immunodiffusion in a gel using monospecific antisera according to G. Manchini (Manchini G., 1965). Statistical processing of data was carried out using the Shapiro criterion. The level of statistical significance of differences between samples was assessed using the nonparametric Mann-Whitney test. Results. The lowest sIg A values and the highest Ig G values in the oral fluid were found in patients of group 4 with generalized periodontitis against the background of type 2 diabetes mellitus. A probable decrease in the level of sIg A was established, in particular, in the 2nd group by 1.27 times, the 3rd by 4.98 times and the 4th by 7.48 times in relation to the data of the control group (p<0, 01). The level of Ig G was probably higher in group 2 by 1.62 times, respectively, in group 3 – by 2.29 times and in group 4 – by 3.35 times, relative to control values (p<0.01 ). At the same time, when studying indicators in blood serum, the results of our studies indicate an imbalance of immunoglobulin fractions in the pathologies under study. Thus, the level of Ig A in the 2nd group was probably 1.7 times higher, in the 3rd group – 1.6 times higher, and in the 4th group – 2.0 times higher, relative to the data in the control group (p<0.001). The level of Ig M in the 2nd group was statistically significantly lower by 1.2 times, while in the 3rd and 4th groups it was probably higher by 1.7 and 1.2 times, respectively. The level of Ig G was probably higher in the 2nd and 3rd groups – by 1.3 times and in the 4th – by 2.0 times, relative to control values (p <0.05). This indicates that type 2 diabetes complicates the course of chronic periodontitis, as evidenced by changes in the concentrations of the main classes of immunoglobulins. Conclusions. Thus, generalized periodontitis against the background of type 2 diabetes mellitus is accompanied by significant changes in local immunity in biological fluids, as evidenced by disruption of the functioning of the humoral part of the adaptive immune system, which is manifested by an increase in the content of the main classes of immunoglobulins Ig A, Ig M, Ig A.

show abstract

“…Hyperglycemia leads to inflammatory response disturbances ( 42 ), enhancing pro-inflammatory cytokines and matrix metalloproteinases (MMP) expression ( 35 ), so the periodontal tissue metabolism adversely affects blood vessels and promotes periodontitis, which develops more rapidly and more intensely ( 43 ), with hyperglycemia enhancing its progression ( 44 , 45 ), even at pre-DM levels ( 46 ). Importantly, hyperglycemia severity, not the DM diagnosis, affects the periodontium ( 47 , 48 ).…”

Section: Periodontal Diseasesmentioning

confidence: 99%

Current scientific evidence for why periodontitis should be included in diabetes management

Borgnakke

2024

Front. Clin. Diabetes Healthc.

View full text Add to dashboard Cite

This Perspective provides a brief summary of the scientific evidence for the two-way links between periodontal diseases and hyperglycemia (diabetes mellitus [DM] and pre-DM). It delivers in a nutshell current scientific evidence for manifestations of hyperglycemia on periodontal health status and effects of periodontal diseases on blood glucose levels and in turn incidence, progression, and complications of diabetes. Of outmost importance is presentation of scientific evidence for the potential of routine periodontal treatment to lower blood glucose levels, providing a novel, economical tool in DM management. Non-surgical periodontal treatment (“deep cleaning”) can be provided by dental hygienists or dentists in general dental offices, although severe cases should be referred to specialists. Such therapy can decrease the costs of DM care and other health care costs for people with DM. The great importance of a healthy oral cavity free of infection and subsequent inflammation – especially periodontitis that if untreated will cause loosening and eventually loss of affected teeth – has largely gone unnoticed by the medical community as the health care curricula are largely void of content regarding the bi-directional links between oral health and systemic health, despite elevation of blood glucose levels being an integral part of the general systemic inflammation response. The importance of keeping disease-free, natural teeth for proper biting and chewing, smiling, self-esteem, and pain avoidance cannot be overestimated. Medical and dental professionals are strongly encouraged to collaborate in patient-centered care for their mutual patients with – or at risk for – hyperglycemia.

show abstract

Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes

Cited by 8 publications

References 31 publications

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Features of Changes in Indicators of Local Immunity of the Oral Cavity and Blood Serum of Patients Against the Background of Generalized Periodontitis and Type 2 Diabetes Mellitus

Current scientific evidence for why periodontitis should be included in diabetes management

Contact Info

Product

Resources

About