2017
DOI: 10.1371/journal.pone.0176493
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Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid transport

Abstract: Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates perturbed gene expression affecting placental angiogenesis and nutrient transfer from mother to fetus. To understand the post-transcriptional mechanisms underlying such placental gene expression changes, our objective was to identify key non-coding microRNAs that express biological function. To this end, we initially undertook microarrays targeting microRNAs in a small sub-set of placentas of appropriate (AGA) versus small f… Show more

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Cited by 53 publications
(43 citation statements)
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“…Among microRNA with an FDR < 0.1 in NHBCS, three were also found in similar studies (hsa-miR-193b-3p 21,28 , hsa-miR-181a 23 , hsa-miR-101-5p 21 ). In RICHS, nine microRNAs were consistent with previous findings (hsa-miR-520a-3p 21 , hsa-miR-193b-5p 21 , hsa-miR-210-3p 21 , hsa-miR-193b-3p 21,28 , hsa-miR-335-3p 28 , hsa-miR-515-5p 21,22 , hsa-miR-519d-5p 21,22,26 , hsa-miR-365b-3p 21 , hsa-miR-365a-3p 21 ). It is reassuring that despite different sampling schemes, study designs and nucleic acid technologies -we see an overlap in these findings even though they did not meet the statistical threshold of FDR < 0.05 in both cohorts for our study.…”
Section: Discussionsupporting
confidence: 89%
“…Among microRNA with an FDR < 0.1 in NHBCS, three were also found in similar studies (hsa-miR-193b-3p 21,28 , hsa-miR-181a 23 , hsa-miR-101-5p 21 ). In RICHS, nine microRNAs were consistent with previous findings (hsa-miR-520a-3p 21 , hsa-miR-193b-5p 21 , hsa-miR-210-3p 21 , hsa-miR-193b-3p 21,28 , hsa-miR-335-3p 28 , hsa-miR-515-5p 21,22 , hsa-miR-519d-5p 21,22,26 , hsa-miR-365b-3p 21 , hsa-miR-365a-3p 21 ). It is reassuring that despite different sampling schemes, study designs and nucleic acid technologies -we see an overlap in these findings even though they did not meet the statistical threshold of FDR < 0.05 in both cohorts for our study.…”
Section: Discussionsupporting
confidence: 89%
“…miRNAs represent a class of conserved small non‐coding RNAs, comprising approximately 22 nucleotides, which influence post‐transcriptional gene accommodation by targeting the 3′ untranslated regions (3′UTRs) of mRNAs, thereby eliciting the degradation or obstruction of translation in miscellaneous biological processes 18, 19, 20, 21. The current findings indicate that compartmentalized stepwise processing of miRNAs takes place first in the nucleus and then in the cytoplasm.…”
Section: Introductionmentioning
confidence: 79%
“…Placental miRNA expression has been previously shown to be influenced by maternal pre-pregnancy BMI (in some cases modified by gestational weight gain) [ 39 ], tobacco smoking [ 42 ], and gestational age [ 56 ]. Epigenetic mechanisms have been shown to be affected by temperature [ 39 , 57 ], therefore adjustment for temperature was taken into account.…”
Section: Methodsmentioning
confidence: 99%