Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist

Hsieh, Candace Y.; Cruikshank, Scott J.; Metherate, Raju

doi:10.1016/s0006-8993(00)02766-9

Cited by 153 publications

(148 citation statements)

References 71 publications

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“…) and the neocortex (GU et al, 1997;Hsieh et al, 2000). Our results indicate that the sensory and intraeortical pathways are differentially modulated by Ach.…”

Section: Cotm~1989supporting

confidence: 50%

“…For each drug the depression started with the short latency response component and occurred throughout ail cortical lamina. Depression of intracortical evoked responses following application of Aeh or muscarinic agonists has been previously described in the neocortex (Hsieh et al, 2000;Gil et al, 1997;Vidal & Cbangeux, 1989, 1992. Although all doses ofexogenous Ach depressed the intracortical response, ooly high doses of endogenous Ach were sufticient to produce depression.…”

Section: Intracortica/ Muscarinic Depressionmentioning

confidence: 80%

“…More recently, Hsieh et al (2000) examined the influence of cholinergic agonists on thalamocortical and intracortical synapses in the auditory cortex in vitro. Stimulation of both pathways resulted in fast EPSPs.…”

Section: Presynaptic Modulationmentioning

confidence: 99%

“…This is an elegant method of accessing thalamocortical tibers, because it isolates a pure pathway from VPM to barrel cortex. Previous studies that have used electrical stimulation of the thalamus, in vitro (Gil et al, 1997;Hsieh et al, 2000) and in vivo (Gioanni et al, 1999), to investigate the modulation of thaIamocortical and intraeortical pathways, are plagued by the criticism that stimulation of the thalamus produces antidromic activation of corticothalamic neurons. Sînce corticothaiamic neurons produce intr8Cortical…”

Section: Goal Of Current Studymentioning

confidence: 99%

“…Previous results have indicated that it bas selective effects on different pathways (Gil et al, 1997;Hsieh et al, 2000). In the cunent study, Ach was applied via microdialysis to the neocortex to examine its effects on the sensory and intraeortical pathways.…”

Section: Effects Ofexogenous Acetylcholinementioning

confidence: 99%

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Input-specific effects of acetylcholine on sensory and intracortical evoked responses in the “barrel cortex” in vivo

2003

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“…) and the neocortex (GU et al, 1997;Hsieh et al, 2000). Our results indicate that the sensory and intraeortical pathways are differentially modulated by Ach.…”

Section: Cotm~1989supporting

confidence: 50%

Section: Intracortica/ Muscarinic Depressionmentioning

confidence: 80%

Section: Presynaptic Modulationmentioning

confidence: 99%

Section: Goal Of Current Studymentioning

confidence: 99%

Section: Effects Ofexogenous Acetylcholinementioning

confidence: 99%

See 3 more Smart Citations

Input-specific effects of acetylcholine on sensory and intracortical evoked responses in the “barrel cortex” in vivo

2003

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Histological Determination of the Areas Enriched in Cholinergic Terminals and m2 and m3 Muscarinic Receptors in the Mouse Central Auditory System

Hamada

Houtani

Trifonov

et al. 2010

The Anatomical Record

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Cholinergic projections to auditory system are vital for coupling arousal with sound processing. Systematic search with in situ hybridization and immunohistochemistry indicated that the ventral nucleus of the medial geniculate body and the nucleus of the brachium of the inferior colliculus constituted cholinergic synaptic sites in the brainstem auditory system, containing a significant number of cholinergic axon terminals and m2 receptor-expressing cell bodies. Anat Rec, 293:1393Rec, 293: -1399

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Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey

2006

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Cholinergic neuromodulation, a candidate mechanism for aspects of attention, is complex and is not well understood. Because structure constrains function, quantitative anatomy is an invaluable tool for reducing such a challenging problem. Our goal was to determine the extent to which m1 and m2 muscarinic acetylcholine receptors (mAChRs) are expressed by inhibitory vs. excitatory neurons in the early visual cortex. To this end, V1 and V2 of macaque monkeys were immunofluorescently labelled for gamma-aminobutyric acid (GABA) and either m1 or m2 mAChRs. Among the GABA-immunoreactive (ir) neurons, 61% in V1 and 63% in V2 were m1 AChR-ir, whereas 28% in V1 and 43% in V2 were m2 AChR-ir. In V1, both mAChRs were expressed by fewer than 10% of excitatory neurons. However, in V2, the population of mAChR-ir excitatory neurons was at least double that observed in V1. We also examined m1 and m2 AChR immunoreactivity in layers 2 and 3 of area V1 under the electron microscope and found evidence that GABAergic neurons localize mAChRs to the soma, whereas glutamatergic neurons expressed mAChRs more strongly in dendrites. Axon and terminal labelling was generally weak. These data represent the first quantitative anatomical study of m1 and m2 AChR expression in the cortex of any species. In addition, the increased expression in excitatory neurons across the V1/V2 border may provide a neural basis for the observation that attentional effects gain strength up through the visual pathway from area V1 through V2 to V4 and beyond.

show abstract

Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist

Cited by 153 publications

References 71 publications

Input-specific effects of acetylcholine on sensory and intracortical evoked responses in the “barrel cortex” in vivo

Input-specific effects of acetylcholine on sensory and intracortical evoked responses in the “barrel cortex” in vivo

Histological Determination of the Areas Enriched in Cholinergic Terminals and m2 and m3 Muscarinic Receptors in the Mouse Central Auditory System

Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey

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