Differential modulation of lateral septal vasopressin receptor blockade in spatial learning, social recognition, and anxiety-related behaviors in rats

Everts, H.; Koolhaas, J.M.

doi:10.1016/s0166-4328(98)00004-7

Cited by 140 publications

(96 citation statements)

References 51 publications

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“…The significantly reduced anxietylike behaviors observed in the V1aRKO subjects provide additional, nonpharmacological support for the role of V1aR in regulating anxiety behavior. Under the conditions used for testing, the WT subjects exhibited elevated levels of anxiety-like behavior relative to other reports (Everts and Koolhaas, 1999). The reasons for this are unclear but could be due to lux levels, time of day, and/or the general conditions in our mouse colony or testing rooms.…”

Section: Discussionmentioning

confidence: 69%

“…Appenrodt et al (1998), reported a decrease in anxietyrelated behavior after central or peripheral AVP administration but no effect of an AVP antagonist, while Liebsch et al (1996) found no effect of AVP on anxiety behavior, but did find a decrease in anxiety-related behavior after treatment with a V1 receptor antagonist. A third group found that AVP receptor antagonism increased anxiety-like behavior (Liebsch et al, 1996;Appenrodt et al, 1998;Everts and Koolhaas, 1999). The V1bR has also been implicated in anxiety, and treatment with an orally active V1bR antagonist resulted in a decrease in anxiety-related behavior in rats (Griebel et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…) and intraseptal administration of V1aR antagonists block social recognition and AVP injections can rescue deficits in social recognition in Brattleboro rats that lack AVP Engelmann and Landgraf, 1994;van Wimersma Greidanus and Maigret, 1996;Everts and Koolhaas, 1999). The effects of V1aR antagonists on anxiety-related behaviors are contradictory, with different groups finding both anxiogenic and anxiolytic effects (Liebsch et al, 1996;Everts and Koolhaas, 1999). Septal administration of V1aR antisense oligos resulted in both impaired social recognition and a decrease in anxiety-related behavior in rats (Landgraf et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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“…Previous work has shown VP increases agonistic behavior in several rodent species, including hamsters and voles. [8][9][10][11] Furthermore, specific V1aR agonists and antagonists also affect aggression, 9,18,19 suggesting that the V1aR mediates some of these effects. We have now shown that V1b receptors must play a role in mediating VP's effects on aggression.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Administration of vasopressin V1a receptor (V1aR) agonists and antagonists affects both of these behaviors. 8,14,[17][18][19] Greater understanding of VP's and its receptors' functions in animal models may lead to improved clinical treatment for aggression. The recently cloned pituitary V1b receptor (V1bR; sometimes referred to as V3R) is also expressed in the brain, 20,21 suggesting a potential role in aggression and other behaviors.…”

Section: Introductionmentioning

confidence: 99%

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoring the need for a better understanding of the neural bases of aggression. Vasopressin, acting through its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much less attention due to a lack of specific drugs. Here we report that mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition. By contrast, they perform normally in all the other behaviors that we have examined, such as sexual behavior, suggesting that reduced aggression and social memory are not simply the result of a global deficit in sensorimotor function or motivation. Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain. We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries. Molecular Psychiatry (2002) 7, 975-984.

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Long-term memory underlying hippocampus-dependent social recognition in mice

2000

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The ability to learn and remember individuals is critical for the stability of social groups. Social recognition reflects the ability of mice to identify and remember conspecifics. Social recognition is assessed as a decrease in spontaneous investigation behaviors observed in a mouse reexposed to a familiar conspecific. Our results demonstrate that group‐housed mice show social memory for a familiar juvenile when tested immediately, 30 min, 24 h, 3 days, and 7 days after a single 2‐min‐long interaction. Interestingly, chronic social isolation disrupts long‐term, but not 30‐min, social memory. Even a 24‐h period of isolation disrupts long‐term social memory, a result that may explain why previous investigators only observed short‐term social memory in individually housed rodents. Although it has no obvious configural, relational, or spatial characteristics, here we show that social memory shares characteristics of other hippocampus‐dependent memories. Ibotenic acid lesions of the hippocampus disrupt social recognition at 30 min, but not immediately after training. Furthermore, long‐term, but not short‐term social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function. These results outline behavioral, systems, and molecular determinants of social recognition in mice, and they suggest that it is a powerful paradigm to investigate hippocampal learning and memory. Hippocampus 2000;10:47–56. © 2000 Wiley‐Liss, Inc.

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Differential modulation of lateral septal vasopressin receptor blockade in spatial learning, social recognition, and anxiety-related behaviors in rats

Cited by 140 publications

References 51 publications

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Long-term memory underlying hippocampus-dependent social recognition in mice

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