Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids

Mashour, George A.; Drissel, Stephanie N; Frahm, Silke; Farassati, Faris; Martuza, Robert L.; Mautner, Victor‐F.; Kindler‐Röhrborn, Andrea; Kurtz, Armin

doi:10.1038/sj.onc.1208425

Cited by 15 publications

(4 citation statements)

References 34 publications

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“…These include platelet-derived growth factor, basic fibroblast growth factor and epidermal growth factor. The role of fatty acids as a possible regulator of MPNST development in neurofibromatosis 1 patients was recently explored by Mashour et al [36]. This group was the first to identify the influence of fatty acids on tumor cell types relevant to neurofibromatosis and the first to suggest that a dietary factor can influence the natural history of neurofibromatosis.…”

Section: Tumor Biologymentioning

confidence: 98%

Peripheral and cranial nerve sheath tumors

Mrugala

Batchelor

Plotkin

2005

Current Opinion in Neurology

104

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Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.

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Section: Tumor Biologymentioning

confidence: 98%

Peripheral and cranial nerve sheath tumors

Mrugala

Batchelor

Plotkin

2005

Current Opinion in Neurology

104

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“…RalA-S28N containing plasmid was purchased from Upstate and has been described previously (2). S805 cells were from the laboratory of V. F. Mautner (45). All cells were maintained in Dulbecco modified Eagle medium with 10% fetal bovine serum supplemented with antibiotics.…”

mentioning

confidence: 99%

Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors

Bodempudi

Yamoutpoor

Pan

et al. 2009

Molecular and Cellular Biology

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Ras leads an important signaling pathway that is deregulated in neurofibromatosis type 1 and malignant peripheral nerve sheath tumor (MPNST). In this study, we show that overactivation of Ras and many of its downstream effectors occurred in only a fraction of MPNST cell lines. RalA, however, was overactivated in all MPNST cells and tumor samples compared to nontransformed Schwann cells. Silencing Ral or inhibiting it with a dominant-negative Ral (Ral S28N) caused a significant reduction in proliferation, invasiveness, and in vivo tumorigenicity of MPNST cells. Silencing Ral also reduced the expression of epithelial mesenchymal transition markers. Expression of the NF1-GTPase-related domain (NF1-GRD) diminished the levels of Ral activation, implicating a role for neurofibromin in regulating RalA activation. NF1-GRD treatment caused a significant decrease in proliferation, invasiveness, and cell cycle progression, but cell death increased. We propose Ral overactivation as a novel cell signaling abnormality in MPNST that leads to important biological outcomes with translational ramifications.

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“…Formation of MPNSTs has also been associated with some important gene mutations and chromosome deletions. These include INK-4A and p53 genes whereas the role of omega-3 and omega-6 fatty acids, in the differential modulation of MPNST's growth has recently been reported (Mashour et al, 2005). These interesting findings have yielded a better understanding of the molecular mechanisms involved in MPNST's growth and hold promise for the development of more effective tumour specific therapies.…”

Section: Discussionmentioning

confidence: 94%