Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females

Boggio, Paulo S.; Rocha, Renata R.; Silva, Mariah Theodoro da; Fregni, Felipe

doi:10.1016/j.neulet.2008.10.009

Cited by 60 publications

(56 citation statements)

References 37 publications

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“…Women had a significantly better tDCS effect on TQ and tinnitus loudness. Gender effects have been previously reported for tDCS over various brain areas including the occipital [3], temporal [1], and frontal cortex [14]. Also, auditory and emotional processing depends on gender.…”

Section: Discussionmentioning

confidence: 81%

Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study

et al. 2011

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Tinnitus is the perception of sound in the absence of an environmental sound source. Abnormal activity in central auditory pathways is considered as the neuronal correlate of tinnitus. However, there is increasing evidence from neuroimaging studies for an additional involvement of the frontal cortex in the pathophysiology of tinnitus, especially concerning its attentional and emotional aspects. Recently, in a subgroup of tinnitus patients, temporary reduction of tinnitus intensity and tinnitus-related distress has been reported after bifrontal tDCS with the anode over the right and the cathode over the left dorsolateral prefrontal cortex (DLPFC). The aim of this study was to investigate whether repeated application of bifrontal tDCS results in longer-lasting reduction of tinnitus and may represent a potential treatment approach. Thirty-two patients with chronic and treatment-resistant tinnitus received six sessions of bifrontal tDCS (1.5 mA, 30 min, two sessions per week) with the anode over the right and the cathode over the left DLPFC. Treatment outcome was assessed with several standardized tinnitus questionnaires, numeric rating scales, and a depression scale. In the entire group, beneficial effects of bifrontal tDCS on tinnitus were found for numeric rating scores of loudness, unpleasantness, and discomfort, but not in tinnitus or depression scales. Exploratory analysis revealed an effect of gender on treatment effects with female patients demonstrating a better response in several scores. Our open-label pilot study suggests some beneficial effect of bifrontal tDCS (anode right and cathode left) in the treatment of severe tinnitus, warranting further controlled studies.

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Section: Discussionmentioning

confidence: 81%

Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study

et al. 2011

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“…Different studies have reported gender-specific effects of tDCS applied to different brain regions, investigating a variety of cognitive abilities, for example to the dorsolateral PFC for verbal working memory34, the left parietal cortex for visual spatial attention35, the bilateral temporal cortex for somatosensory integration36, and the bilateral superior temporal cortex for facial expression recognition37. A second possible non-specific interpretation could rely on gender-related neuroanatomical differences .…”

Section: Discussionmentioning

confidence: 99%

Gender differences in cognitive Theory of Mind revealed by transcranial direct current stimulation on medial prefrontal cortex

Adenzato

Brambilla

Manenti

et al. 2017

Sci Rep

105

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Gender differences in social cognition are a long discussed issue, in particular those concerning Theory of Mind (ToM), i.e., the ability to explain and predict other people’s mental states. The aim of this randomized, double-blind, placebo-controlled study was to test the hypothesis that anodal tDCS over the medial prefrontal cortex (mPFC) selectively enhances cognitive ToM performance in females. In the first experiment we administered to sixteen females and sixteen males a cognitive ToM task during anodal or placebo tDCS over the mPFC. In the second experiment further sixteen females completed the task receiving anodal or placebo tDCS over the vertex. The results showed that anodal tDCS over the mPFC enhances ToM in females but not in males, an effect indicated by enhanced ToM in females that received anodal tDCS over the mPFC compared with females that received tDCS over the vertex. These findings are relevant for three reasons. First, we found evidence of gender-related differences in cognitive ToM, extending previous findings concerning affective ToM. Second, these differences emerge with anodal stimulation of the mPFC, confirming the crucial role of this area in cognitive ToM. Third, we show that taking into account gender-related differences is mandatory for the investigation of ToM.

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“…This finding could be explained by sex differences in the anatomical location of the DLPFC [84] and in cognitive task performance and associated brain activation patterns (e.g. women take a more 'top-down' cognitive strategy than men, relying more heavily on higher-order frontal regions, which is enhanced by DLPFC tDCS) [85]; or, most plausibly, hormonal differences affecting brain stimulation induced changes in cortical excitability between women and men [86][87][88], as demonstrated previously in studies investigating the effects of rTMS on cortical excitability [89,90]. However, the finding that gender influences the effects of stimulation dose on a-tDCS efficacy for accuracy rates should be interpreted with caution, as our meta-analysis is based on aggregate, and not individual patient data [91,92].…”

Section: Healthy Participantsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of the Effects of Transcranial Direct Current Stimulation (tDCS) Over the Dorsolateral Prefrontal Cortex in Healthy and Neuropsychiatric Samples: Influence of Stimulation Parameters

et al. 2016

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Background:Research into the effects of transcranial direct current stimulation of the dorsolateral prefrontal cortex on cognitive functioning is increasing rapidly. However, methodological heterogeneity in prefrontal tDCS research is also increasing, particularly in technical stimulation parameters that might influence tDCS effects.Objective: To systematically examine the influence of technical stimulation parameters on DLPFC-tDCS effects. Methods:We performed a systematic review and meta-analysis of tDCS studies targeting the DLPFC published from the first data available to February 2016. Only single-session, sham-controlled, within-subject studies reporting the effects of tDCS on cognition in healthy controls and neuropsychiatric patients were included. Results:Evaluation of 61 studies showed that after single-session a-tDCS, but not c-tDCS, participants responded faster and more accurately on cognitive tasks. Sub-analyses specified that following a-tDCS, healthy subjects responded faster, while neuropsychiatric patients responded more accurate. Importantly, different stimulation parameters affected a-tDCS effects, but not c-tDCS effects, on accuracy in healthy samples vs. patients: increased current density and density charge resulted in improved accuracy in healthy samples, most prominently in females; for neuropsychiatric patients, task performance during a-tDCS resulted in stronger increases in accuracy rates compared to task performance following a-tDCS. Conclusions:Healthy participants respond faster, but not more accurate on cognitive tasks after a-tDCS.However, increasing the current density and/or charge might be able to enhance response accuracy, particularly in females. In contrast, online task performance leads to greater increases in response accuracy than offline task performance in neuropsychiatric patients. Possible implications and practical recommendations are discussed.

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Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females

Cited by 60 publications

References 37 publications

Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study

Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study

Gender differences in cognitive Theory of Mind revealed by transcranial direct current stimulation on medial prefrontal cortex

A Systematic Review and Meta-Analysis of the Effects of Transcranial Direct Current Stimulation (tDCS) Over the Dorsolateral Prefrontal Cortex in Healthy and Neuropsychiatric Samples: Influence of Stimulation Parameters

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