Differential morphine effects on short- and long-latency laser-evoked cortical responses in the rat

Tsai, Meng‐Li; Kuo, Chung-Chih; Sun, Wei‐Zen; Yen, Chen‐Tung

doi:10.1016/j.pain.2004.05.016

Cited by 29 publications

(30 citation statements)

References 21 publications

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“…The characters of these two responses on location (contralateral anterior parietal area) and waveform (sharp) imply that they may be related to the sensory-discrimination of noxious laser stimulation. The peak latencies of the two responses are similar to those reported previously (Shaw et al 1999(Shaw et al , 2001Tsai et al 2004). Another type of response which has not been reported in previous studies is the late and long-lasting blunt wave (channel FL2, FR2).…”

Section: Discussionsupporting

confidence: 89%

Dynamic Processing of Nociception in Cortical Network in Conscious Rats: A Laser-evoked Field Potential Study

et al. 2007

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(1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.

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Section: Discussionsupporting

confidence: 89%

Dynamic Processing of Nociception in Cortical Network in Conscious Rats: A Laser-evoked Field Potential Study

et al. 2007

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“…Peristimulus time histograms were generated with a bin size of 200 ms. Single units from each ensemble were normalized as z-scores (Tsai et al, 2004). In brief, the 5 s period before stimulation was used as a baseline period.…”

Section: Methodsmentioning

confidence: 99%

Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning

Steenland¹,

Li²,

Zhuo³

2012

J. Neurosci.

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A variety of studies have implicated the anterior cingulate cortex (ACC) in fear, including permanent storage of fear memory. Recent pharmacological and genetic studies indicate that early synaptic plasticity in the ACC may also contribute to certain forms of fear memory at early time points. However, no study has directly examined the possible changes in neuronal activity of ACC neurons in freely behaving mice during early learning. In the present study, we examined the neural responses of the ACC during trace fear conditioning. We found that ACC putative pyramidal and nonpyramidal neurons were involved in the termination of fear behavior ("un-freezing"), and the spike activity of these neurons was reduced during freezing. Some of the neurons were also found to acquire un-freezing locked activity and change their tuning. The results implicate the ACC neurons in fear learning and controlling the abolition of fear behavior. We also show that the ACC is important for making cue-related fear memory associations in the trace fear paradigm as measured with tone-evoked potentials and single-unit activity. Collectively, our findings indicate that the ACC is involved in predicting future aversive events and terminating fear during trace fear.

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“…A ''boxcar'' filter (with a width of three bins) was used for postprocessing. Multiunit responses were normalized as Z scores (Tsai et al, 2004). Briefly, the 50-msec period before stimulation was used as the baseline period.…”

Section: Surgery Preparationmentioning

confidence: 99%

Functional Connectivity of the Secondary Somatosensory Cortex of the Rat

Liao

Yen

2008

The Anatomical Record

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The hierarchical relationship of the rat primary somatosensory cortex (S1) and secondary somatosensory cortex (S2) is controversial. The existence of a direct thalamocortical projection from ventral posterolateral thalamic nucleus (VPL) to S2 is a key factor in determining the relative position of S2 in the processing flow. In this study, the inter-connections of forepaw and hindpaw representations in VPL, S1, and S2 were examined by neuroanatomical tracing and electrophysiological approaches. In the tracing experiments, VPL, S1, and S2 were electrophysiologically identified, and then iontophoretically injected with biotinylated dextran amine (BDA, a bi-directional tracer). In the double-labeling experiments, two of the following retrograde tracers-BDA, Rhodamine dextran (RD), and/or Fluoro-Gold (FG)-were injected into homotypical S1 and S2 forepaw representations simultaneously. In the electrophysiological studies, paired somatic evoked multiunit responses in S1 and S2 were compared. Our results revealed that: (1) VPL forepaw and hindpaw neurons projected to corresponding S1 and S2 areas in a parallel and somatotopic manner; (2) very low percentage of double projecting VPL neurons were found, indicating parallel and independent pathways from forepaw VPL to S1 and S2; (3) forepaw S1 and S2 were symmetrically and reciprocally connected; (4) response latencies of the S1 and S2 multiunits to forepaw stimulation were in accordance with a direct and parallel pathway. This study provides further evidence to support the equivalent hierarchy of S1 and S2 in processing sensory information of the rat. Anat Rec, 291:960-973, 2008. 2008 Wiley-Liss, Inc.Key words: parallel; primary somatosensory cortex; serial; ventral posterolateral thalamic nucleusThe peripheral somatosensory information is known to convey to the contralateral primary somatosensory cortex (S1) and secondary somatosensory cortex (S2).Although extensive studies have been carried out on the thalamocortical and corticothalamic circuitry of the somatosensory system, whether S1 and S2 process Abbreviations used: Ang 5 angular thalamic nucleus; BDA 5 biotinylated dextran amine; CPu 5 caudate putamen; eml 5 external medullary lamina; ic 5 internal capsule; ml 5 medial lemniscus; POm 5 posterior medial nucleus; RD 5 rhodamine dextran; Rt 5 reticular thalamic nucleus; str 5 superior thalamic radiation; VA 5 ventroanterior thalamic nucleus; VL 5 ventrolateral thalamic nucleus; VM 5 ventromedial thalamic nucleus; VPL 5 ventral posterolateral thalamic nucleus; VPM 5 ventral posteromedial thalamic nucleus; ZId 5 zona incerta, dorsal part.

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Differential morphine effects on short- and long-latency laser-evoked cortical responses in the rat

Cited by 29 publications

References 21 publications

Dynamic Processing of Nociception in Cortical Network in Conscious Rats: A Laser-evoked Field Potential Study

Dynamic Processing of Nociception in Cortical Network in Conscious Rats: A Laser-evoked Field Potential Study

Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning

Functional Connectivity of the Secondary Somatosensory Cortex of the Rat

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