Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease

Gonzalez-Hidalgo, Carmen; Haro, Joaquín De; Bleda, Silvia; Cañibano, Cristina; Michel, Ignacio; Aciń, Francisco

doi:10.1177/1753944717750338

Cited by 22 publications

(14 citation statements)

References 29 publications

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“…Immunohistochemical analysis indicated a strong expression of ASC, Caspase-1, Caspase-5, NLRP3, and AIM2, predominantly in sporadic infiltrating lymphoid cells and in lymphoid aggregates located in the outer media and adventitia of AAA samples (Figure 3 and [29,30]). In line with these findings, the gene expressions of ASC, CASP1, IL1B, NLRP3, and IFI16 were found to be increased in the aortic wall of AAA specimen, compared to controls [29,31,32].…”

Section: Inflammasome Genes and Proteins Are Expressed In Different Cell Types Of Aortic Aneurysmssupporting

confidence: 74%

Inflammasomes in the Pathophysiology of Aortic Disease

Wortmann

Peters

Erhart

et al. 2021

Cells

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Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general, aging is associated with a slow but progressive dilation of the aorta, along with increased stiffness and pulse pressure. The progression of aortic disease is characterized by subclinical development or acute presentation. Recent evidence suggests that inflammation participates causally in different clinical manifestations of aortic diseases. As of yet, diagnostic imaging and surveillance is mainly based on ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). Little medical therapy is available so far to prevent or treat the majority of aortic diseases. Endovascular therapy by the introduction of covered stentgrafts provides the main treatment option, although open surgery and implantation of synthetic grafts remain necessary in many situations. Because of the risks associated with surgery, there is a need for identification of pharmaceutical targets interfering with the pathophysiology of aortic remodeling. The participation of innate immunity and inflammasome activation in different cell types is common in aortic diseases. This review will thus focus on inflammasome activities in vascular cells of different chronic and acute aortic diseases and discuss their role in development and progression. We will also identify research gaps and suggest promising therapeutic targets, which may be used for future medical interventions.

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Section: Inflammasome Genes and Proteins Are Expressed In Different Cell Types Of Aortic Aneurysmssupporting

confidence: 74%

Inflammasomes in the Pathophysiology of Aortic Disease

Wortmann

Peters

Erhart

et al. 2021

Cells

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“…Single-nucleotide polymorphisms in NLRP1 are associated with an increased risk of developing type-1 diabetes and systemic lupus erythematosus (SLE) in Brazilian population cohorts (113). Patients with aortic occlusive disease (AOD) have exhibited higher mRNA expression of NLRP1 than healthy individuals (153).…”

Section: Role Of Nlrp1mentioning

confidence: 99%

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Suryavanshi

Kovalchuk

2021

Front. Immunol.

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Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1–mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the development of chronic inflammatory disorders in contrast to their role in regulating innate immunity. Cannabis (marijuana) is a natural product obtained from the Cannabis sativa plant, and pharmacologically active ingredients of the plant are referred to as cannabinoids. Cannabinoids and cannabis extracts have recently emerged as promising novel drugs for chronic medical conditions. Growing evidence indicates the potent anti-inflammatory potential of cannabinoids, especially Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and synthetic cannabinoids; however, the mechanisms remain unclear. Several attempts have been made to decipher the role of cannabinoids in modulating inflammasome signaling in the etiology of chronic inflammatory diseases. In this review, we discuss recently published evidence on the effect of cannabinoids on inflammasome signaling. We also discuss the contribution of various cannabinoids in human diseases concerning inflammasome regulation. Lastly, in the milieu of coronavirus disease-2019 (COVID-19) pandemic, we confer available evidence linking inflammasome activation to the pathophysiology of COVID-19 suggesting overall, the importance of cannabinoids as possible drugs to target inflammasome activation in or to support the treatment of a variety of human disorders including COVID-19.

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“…Regarding the pathogenesis of aortic aneurysm, aortas from patients showed increased Nlrp3 and Il1b expression levels ( 142 ). Inhibition of this cytokine or its receptor in a murine model resulted in a preserved aorta structure and reduced inflammation ( 143 ).…”

Section: Nucleotide-binding Oligomerization Domain-like Receptorsmentioning

confidence: 99%