Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Eyre, David W; Lumley, Sheila F; O’Donnell, Denise; Campbell, Mark; Sims, Elizabeth; Lawson, Elaine; Warren, Fiona C; James, Tim; Cox, Stuart; Howarth, Alison; Doherty, George; Hatch, Stephanie B.; Kavanagh, James; Chau, Kevin; Fowler, Philip W.; Swann, Jeremy; Volk, Denis; Yang-Turner, Fan; Stoesser, Nicole; Matthews, Philippa C.; Dudareva, Maria; Davies, Timothy; Shaw, R. H.; Peto, Leon; Downs, Louise; Vogt, Alexander; Amini, Ali; Young, Bernadette C.; Drennan, Philip G.; Mentzer, Alexander J.; Skelly, Donal; Karpe, Fredrik; Neville, Matthew J.; Andersson, Monique; Brent, Andrew; Jones, N; Ferreira, Lucas Martins; Christott, Thomas; Marsden, Brian D.; Hoosdally, Sarah; Cornall, Richard J.; Crook, Derrick W.; Stuart, D.I.; Screaton, Gavin; Peto, Timothy E. A.; Holthof, Bruno; A-M., O'Donnell; Ebner, Daniel; Conlon, Christopher P.; Jeffery, Katie; Walker, Timothy M

doi:10.7554/elife.60675

Cited by 231 publications

(334 citation statements)

References 13 publications

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“…This can be explained by the lack of protection and information in the most unprotected social strata, and in this we agree with Hawkins et al [ 21 ]. Curiously, healthcare workers showed much smaller frequencies than those reported by other authors as Eyre et al [ 22 ], although as we previously said, the sample is not large enough to draw conclusions in this regard. In our opinion, cutaneous manifestations of COVID-19 can be significantly polymorphic, occasionally non-specific, and ultimately resolve spontaneously.…”

Section: Discussioncontrasting

confidence: 62%

Cutaneous Manifestations in COVID-19: Report on 31 Cases from Five Countries

Rodríguez-Cerdeira

Uribe-Camacho

Silverio-Carrasco

et al. 2021

Biology

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The increasingly frequent cutaneous manifestations of coronavirus disease (COVID-19) remain to pose a problem to clinicians. Herein, we aimed to describe the clinical and pathological findings of skin lesions in patients with COVID-19. The case series, which was based on the International Dermatological Registry circulated to dermatologists worldwide, was conducted across organizations and societies belonging to five different countries. We documented 31 patients with dermatologic manifestations associated with COVID-19, including maculopapular rashes (16.10%), urticarial lesions (26.80%), pseudochilblains (22.60%), petechiae/purpura (6.50%), distal ischaemia and necrosis (6.50%), livedo racemosa (12.90%), and others (9.70%). Twenty-six cases (83.90%) were qRT-PCR-confirmed COVID-19 cases, two (6.50%) were serologically confirmed, while two others (9.7%) were suspected cases owing to previous contact with COVID-19-positive patients. Therefore, our findings indicate that a febrile rash or even a rash in an afebrile state in the early stages of the disease may be the only clinical manifestation of COVID-19. In the future, we recommend close monitoring of all patients with skin lesions not attributable to other causal factors; in the diagnostic perspective, clinicians should aim to confirm if the skin lesions are associated with COVID-19.

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Section: Discussioncontrasting

confidence: 62%

Cutaneous Manifestations in COVID-19: Report on 31 Cases from Five Countries

Rodríguez-Cerdeira

Uribe-Camacho

Silverio-Carrasco

et al. 2021

Biology

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“…Asymptomatic health care workers were invited to participate in voluntary nasal and oropharyngeal swab PCR testing every 2 weeks and serologic testing every 2 months (with some participating more frequently for related studies) beginning on April 23, 2020, as previously described. 5 , 22 Staff were followed until November 30, 2020. Deidentified data were obtained from the Infections in Oxfordshire Research Database, which has generic research ethics committee, Health Research Authority, and Confidentiality Advisory Group approvals.…”

Section: Methodsmentioning

confidence: 99%

“…The 60-day window was prespecified to exclude persistence of PCR-positive RNA after the index infection that led to seroconversion, on the basis of earlier reports of RNA persistence for 6 weeks or more. 22 , 25 , 26 Similarly, we considered only PCR-positive tests occurring at least 60 days after the previous PCR-positive test.…”

Section: Methodsmentioning

confidence: 99%

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

et al. 2021

Self Cite

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“…38 The adequate and correct use of PPE is the best measure to prevent HCWs from acquiring COVID-19 infection. 39 However, at the early stage of the outbreak, a global shortage of PPE occurred, and HCWs lacked practice on the proper donning and doffing of PPE. 40 Insufficient knowledge and skills related to the isolation of respiratory diseases pose a high risk of infection with HCWs.…”

Section: Open Accessmentioning

confidence: 99%

Knowledge, attitude and practice concerning healthcare-associated infections among healthcare workers in Wuhan, China: cross-sectional study

Wang

Yua

et al. 2021

BMJ Open

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ObjectivesTo assess the knowledge, attitude and practice (KAP) concerning healthcare-associated infections (HAIs) among healthcare givers and to identify the factors influencing KAP.DesignThis was a hospital-based, cross-sectional study.SettingTwo public hospitals in Wuhan, central China.ParticipantsParticipants were recruited among healthcare workers (HCWs) of one general hospital and one children’s hospital in Wuhan city between 1 June and 30 September 2019.Primary and secondary outcome measuresThe outcomes were KAPs concerning HAIs.ResultsData from 455 HCWs were included in the final data analysis. The mean scores of KAP and total KAP were 15.67±3.32, 25.00±2.75, 43.44±5.15 and 84.76±6.72, respectively. The following factors were significantly associated with the total KAP score concerning HAIs, explaining 61% of the variance (p<0.001): gender (β=2.36, 95% CI 1.11 to 4.40), age (β=6.65, 95% CI 5.07 to 7.74), position (β=7.02, 95% CI 3.88 to 8.45), type of employment (β=−1.08, 95% CI −2.08 to −0.07), with HAI education within last year (β=−2.98, 95% CI −4.23 to −1.72), with invasive operation authority (β=−4.22, 95% CI −5.46 to −2.99), antibacterial drug training (β=−4.38, 95% CI −5.45 to −3.31) and with antibacterial drug training and clinical consultation (β=−4.35, 95% CI −5.38 to −3.32).ConclusionThe controllable factors identified in this study can be used by hospital managers to implement measures that improve KAP among HCWs. Moreover, these measures should be customised, based on uncontrollable factors to suit the specific characteristics of medical staff and to improve KAP. Training programmes should be designed for medical workers to increase their awareness of HAIs and to foster positive attitudes and practices.

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Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Cited by 231 publications

References 13 publications

Cutaneous Manifestations in COVID-19: Report on 31 Cases from Five Countries

Cutaneous Manifestations in COVID-19: Report on 31 Cases from Five Countries

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

Knowledge, attitude and practice concerning healthcare-associated infections among healthcare workers in Wuhan, China: cross-sectional study

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