Differential Optical Density of Subretinal Spaces

Neudorfer, Meira; Weinberg, Amit; Loewenstein, Anat; Barak, Adiel

doi:10.1167/iovs.11-8700

Cited by 47 publications

(44 citation statements)

References 10 publications

(12 reference statements)

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“…In the literature on OCT optical intensity quantitative analysis, a few studies used raw data, 14,23,24 while others used exported pictures in formats such as .jpeg, 11,25 .tiff, 26 or .bmp. 12 Image processing or compressing may change the intensity value, and raw data analysis was used in our study.…”

Section: Discussionmentioning

confidence: 99%

“…12 Image processing or compressing may change the intensity value, and raw data analysis was used in our study. Most reports have analyzed 1D A-scan 14,23,24 or 2D images 11,12,15 and focused on only one or two layers, while our analysis is based on 3D data and included all currently segmented retinal layers. As a result, our study provides more complete information about the scanned area.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, vitreous, RNFL, and RPE have been chosen by others as a reference to normalize the optical intensity. [11][12][13]15,26 A possible reason is that vitreous has the lowest intensity while RNFL or RPE has the highest intensity. However, our results showed that in normal subjects, RNFL and RPE have the largest standard deviation of all layers.…”

Section: Discussionmentioning

confidence: 99%

“…In 2000, Pons et al 8 reported that the internal reflectivity of RNFL was lower in patients with glaucoma compared to controls. This observation was recently confirmed using spectral-domain OCT. 9,10 The optical intensity was also quantitatively investigated in subretinal space, 11,12 photoreceptor, 13 and intraretinal space 14 and in choroidal neovascularization. 15 Outside the retina, it has also been investigated in filtering blebs 16 and posterior capsule.…”

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confidence: 99%

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Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

Chen

Hou

Jin

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Chen X, Hou P, Jin C, et al. Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography. Invest Ophthalmol Vis Sci. PURPOSE.To investigate the optical intensities of all retinal layers on three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement. METHODS.Forty normal subjects underwent Topcon 3D OCT-1000 macula-centered scan. The raw data were automatically segmented into 10 layers using the 3D graph search approach. Then the mean and standard deviation of intensities of each layer were calculated. The image quality index was given by the OCT software. Correlation analysis was performed between the optical intensities in each layer and image quality and subject's age.RESULTS. The correlation of optical intensities was strong from ganglion cell layer (GCL) to outer nuclear layer (ONL) with r > 0.934; moderate among retinal nerve fiber layer (RNFL), photoreceptor, retinal pigment epithelium (RPE), and choroid (0.410 < r < 0.800); and low in the vitreous (0.251 < r < 0.541). The optical intensities were also correlated with the image quality, r > 0.869 from GCL to ONL, 0.748 < r < 0.802 for RNFL, photoreceptor layer, RPE, and the choroid, r ¼ 0.528 for the vitreous. The optical intensity in RNFL was negatively correlated with age (r ¼ À0.365).CONCLUSIONS. Automatic assessment of the layers' intensities was achieved. In normal subjects, the retinal layers' optical intensities were affected by image quality. Normalization with optical intensity of ONL, all areas, or image quality index is recommended. The optical intensity of RNFL decreased with age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

Chen

Hou

Jin

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Several features of CCH in SD-OCT have been described [16, 17], including the presence of associated subretinal fluid (SRF) [3]. The OCT image makes it possible to measure substance reflectivity and to evaluate the SRF by calculating the ODR of the SRF (described in detail by our group elsewhere) [18]. …”

Section: Introductionmentioning

confidence: 99%

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma

et al. 2018

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Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF). Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Results: The mean ODR of the SRF was 0.808 ± 0.287. Tumor base measured on ultrasound correlated significantly with the ODR (p = 0.012). ODR values in cases of CCH were similar to those of choroidal metastasis, but significantly lower than those of choroidal melanoma (p = 0.006). Thirty-two out of 34 cases (94%) presented with a regular smooth choroidal surface. OCT demonstrated SRF overlying the CCH in 29 eyes (85%). The presence of SRF correlated significantly with a larger basal tumor diameter (p = 0.035). OCT displayed sub- and intraretinal hyperreflective foci, correlating with both larger maximal retinal thickness overlying the tumor (p = 0.031) and the amount of SRF (p = 0.016) in 29 eyes (85%). Conclusion: CCH displays typical findings on SD-OCT. ODR is a new important tool in the differential diagnosis of choroidal tumors and should be considered for enhancing the accuracy of diagnosing CCH. This benefit is especially relevant for cases in which the presentation of CCH is atypical.

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Novel Use of Existing Imaging Modalities to Assess Intraocular Inflammation

Denniston

Keane

2017

Multimodal Imaging in Uveitis

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Differential Optical Density of Subretinal Spaces

Cited by 47 publications

References 10 publications

Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma

Novel Use of Existing Imaging Modalities to Assess Intraocular Inflammation

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