Differential organotin sensitivity in two<i>Leucozonia</i>species from a ship traffic area in southeastern Brazil

Costa, Mércia Barcellos da; Zamprogno, Gabriela Carvalho; Pedruzzi, Felipe C.; Morais, Letícia de; Tognella, Mônica Maria Pereira; Godoi, Ana F. L.; Santos, Dayana Moscardi dos; Marchi, Mary Rosa Rodrigues de; Fernandez, Marcos Antônio

doi:10.1080/17451000.2013.850512

Cited by 11 publications

(13 citation statements)

References 64 publications

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“…This region has high levels of TBT and its metabolites were detected (Costa et al, 2014). So far there have been only records malformations in the genus Leucozonia.…”

Section: Discussionmentioning

confidence: 99%

“…The Espirito Santo Bay has intense maritime traffic due to the presence of ports and marinas in the region and has been monitored since 2007 with the species Stramonita haemastoma (unpublished data), Thais deltoidea (Costa et al, 2008a), Cymatium parthenopeumparthenopeum (Costa et al, 2008b), Leucozonia nassa and L. ocellata (Costa et al, 2014). This region has high levels of TBT and its metabolites were detected (Costa et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Samples were collected at six sites in this bay ( Figure 1): site 1-Point of Tubarão (369078, 7757961, site 2-Socó island (365753, 7756521), site 3 -Formosa beach (365531, 7755197), site 4 -Frade island beach (366347, 7754743), site 5 -Ribeiro beach (3671178, 7752228) and site 6 -Sossego beach (366973,7752564). This area has been studied, and the occurrence of high levels of imposex confirms that pollution by TBT is producing deleterious effects on the local populations of gastropods (Costa et al, 2008a, b;Costa et al, 2014). …”

Section: Study Areamentioning

confidence: 99%

“…Studies conducted in Espirito Santo Bay, Brazil, have shown the presence of high levels of contamination by TBT and its metabolites in the sediment in this area (Costa et al, 2014). The objective of this study was to verify the occurrence of malformation in males and imposexed females of the gastropods L. nassa and L. ocellata and its probable relationship to the occurrence of imposex in this region.…”

Section: Introductionmentioning

confidence: 99%

“…Other species are also being used in biomonitoring programs, such as Thais deltoidea (Costa et al, 2008a), Cymatium parthenopeumparthenopeum (Costa et al, 2008b), Nassarius vibex (Cardoso et al, 2010) and species of the family Fasciolariidae, including Leucozonia nassa and Leucozonia ocellata (Costa et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Penis Malformations in Leucozonia nassa (Gmelin, 1792) and Leucozoniaocellata (Gmelin, 1791) in a TBT Contaminated Region from Brazil

Costa¹,

Mardegan²,

Zamprogno³

et al. 2014

AST

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Gastropod molluscs have potential for bioaccumulation of the organotin compounds (OTs) as tributyltin (TBT) and/or triphenyltin (TPT), used in antifouling paints applied to the hulls of ships to prevent biofouling. In gastropods, TBT may act as endocrine disruptors, and to induce imposex, impairing their reproductive capacity. The present study aimed to verify the occurrence of malformations, such as biphalic and triphalic penis in males and females with imposex in Leucozonia nassa and L. ocellata collected in Espírito Santo Bay between the years 2007 and 2011. During this period, 94.8% of female L. nassa and 24.5% of female L. ocellata exhibited imposex and 10 animals presented malformations. For L. nassa, malformations were found in seven females and one male, and for L. ocellata in two males. Most females with malformations presented VDSI stage ≥4 and these results indicate high levels of TBT contamination in the Espirito Santo Bay.

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“…This region has high levels of TBT and its metabolites were detected (Costa et al, 2014). So far there have been only records malformations in the genus Leucozonia.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Areamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Penis Malformations in Leucozonia nassa (Gmelin, 1792) and Leucozoniaocellata (Gmelin, 1791) in a TBT Contaminated Region from Brazil

Costa¹,

Mardegan²,

Zamprogno³

et al. 2014

AST

Self Cite

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A temporal and spatial monitoring of organotin pollution in a harborside region of Brazil by imposex and ecological quality ratio using Leucozonia nassa

Costa

Zamprogno

Otegui

et al. 2017

Environ Monit Assess

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This study represents the first use of Leucozonia nassa (Mollusca-Gastropoda) in a program of long-term monitoring. Specimens of L. nassa were collected between 2006 and 2014 and analyzed for the occurrence of imposex in two areas in Southeastern Brazil, one control area and another characterized by the presence of many ports and marinas. Imposex was evaluated in nine sites based on the percentage of females exhibiting imposex (I%), relative penis length index and vas deferens sequence index, classical indices to evaluate tributyltin (TBT) impacts. Moreover, this study uses for the first time in a tropical environment the ecological quality ratio (EQR), an approach to verify the imposex levels as an indicator of the impact by organotin compounds according to the EU Water Framework Directive. The results confirm the occurrence of high levels of imposex in L. nassa with all the indices evaluated. Furthermore, the results also indicate that, despite the international ban, antifouling paints based on TBT are still possibly used in Brazil. In addition, this study shows that L. nassa has the characteristics that make it a suitable bioindicator to monitor TBT pollution, and that the use of the EQR may create important data regarding this problem.

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Tributyltin chloride disrupts aortic vascular reactivity and increases reactive oxygen species production in female rats

Ximenes

Rodrigues

Podratz

et al. 2017

Environ Sci Pollut Res

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Organotin compounds, such as tributyltin (TBT), are environment contaminants that induce bioaccumulation and have potential toxic effects on marine species and mammals. TBT have been banned by the International Maritime Organization in 2003. However, the assessment of butyltin and metal contents in marine sediments has demonstrated high residual levels of TBT in some cases exceeding 7000 ng Sn g. The acceptable daily intake (ADI) level for TBT established by the World Health Organization is 0.5 μg/kg bw/day is based on genotoxicity, reproduction, teratogenicity, immunotoxicity, and mainly neurotoxicity. However, their effect on the cardiovascular system is not well understood. In this study, female rats were exposed to 0.5 μg/kg/day of TBT for 15 days with the goal of understanding the effect of TBT on vascular function. Female Wistar rats were treated daily by gavage and divided into control (n = 10) and TBT (n = 10) groups. The aortic rings were incubated with phenylephrine in both the presence and absence of endothelium. The phenylephrine concentration-response curves were generated by exposing endothelium-intact samples to N-nitro-L-arginine methyl ester (L-NAME), apocynin, superoxide dismutase (SOD), catalase, tiron, and allopurinol. Acetylcholine (ACh) and sodium nitroprusside (SNP) were used to evaluate the relaxation response. Exposure to TBT reduced serum 17β-estradiol E levels and increased vascular reactivity. After incubation with L-NAME, the vascular reactivity to phenylephrine was significantly higher. Apocynin, SOD, catalase, and tiron decreased the vascular reactivity to phenylephrine to a significantly greater extent in TBT-treated rats than in the control rat. The relaxation induced by ACh and SNP was significantly reduced in TBT rats. Exposure to TBT induced aortic wall atrophy and increased superoxide anion production and collagen deposition. These results provide evidence that exposing rats to the current ADI for TBT (0.5 μg/kg) for 15 days induced vascular dysfunction due to oxidative stress and morphological damage and should be considered an important cardiovascular risk factor.

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Differential organotin sensitivity in twoLeucozoniaspecies from a ship traffic area in southeastern Brazil

Cited by 11 publications

References 64 publications

Penis Malformations in Leucozonia nassa (Gmelin, 1792) and Leucozoniaocellata (Gmelin, 1791) in a TBT Contaminated Region from Brazil

Penis Malformations in Leucozonia nassa (Gmelin, 1792) and Leucozoniaocellata (Gmelin, 1791) in a TBT Contaminated Region from Brazil

A temporal and spatial monitoring of organotin pollution in a harborside region of Brazil by imposex and ecological quality ratio using Leucozonia nassa

Tributyltin chloride disrupts aortic vascular reactivity and increases reactive oxygen species production in female rats

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