2016
DOI: 10.1080/01480545.2016.1188300
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Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicityin vivo

Abstract: Although CN and VO induced oxidative stress through ROS production, our findings suggest a difference in the threshold of ROS production and cytotoxicity for both forms of ischemia. However, this threshold is dependent on the availability of oxygen to fuel mitochondria-ROS production in oxidative stress. Ultimately, the difference in oxygen availability in vivo determined the significance of lipid peroxidation, calcium-shift and autophagic cell response associated with the ischemia. CN treatment generated more… Show more

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