2023
DOI: 10.3390/ijms241310544
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Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust

Abstract: The combined toxicological effects of airborne particulate matter (PM), such as PM2.5, and Asian sand dust (ASD), with surrounding chemicals, particularly quinones, on human airway epithelial cells remain underexplored. In this study, we established an in vitro combination exposure model using 1,2-naphthoquinones (NQ) and 9,10-phenanthroquinones (PQ) along with heated PM (h-PM2.5 and h-ASD) to investigate their potential synergistic effects. The impacts of quinones and heated PM on tetrazolium dye (WST-1) redu… Show more

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Cited by 2 publications
(1 citation statement)
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“…Air pollutants, including PMs, ozone, NO, NO 2 , and DEPs, activate ROS and induce cell death, leading to the secretion of alarmins like IL-33 and driving type 2 inflammation. PM 2.5 , a component of air pollution, triggers various forms of cell death and proinflammatory transcription factors, such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), in human bronchial cells, resulting in excessive inflammation, and immune responses ( 14 , 82–84 ). In addition, DEP and ozone exposure increases alarmin levels in respiratory epithelial cells ( 13 , 85 , 86 ).…”
Section: Mechanisms and Pathological Events Involved In Epithelial Ba...mentioning
confidence: 99%
“…Air pollutants, including PMs, ozone, NO, NO 2 , and DEPs, activate ROS and induce cell death, leading to the secretion of alarmins like IL-33 and driving type 2 inflammation. PM 2.5 , a component of air pollution, triggers various forms of cell death and proinflammatory transcription factors, such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), in human bronchial cells, resulting in excessive inflammation, and immune responses ( 14 , 82–84 ). In addition, DEP and ozone exposure increases alarmin levels in respiratory epithelial cells ( 13 , 85 , 86 ).…”
Section: Mechanisms and Pathological Events Involved In Epithelial Ba...mentioning
confidence: 99%