2010
DOI: 10.1007/s10753-010-9215-2
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Differential Pharmacological Behaviour of p38 Inhibitors in Regulating the LPS-Induced TNF-α Production in Human and Rat Whole Blood In Vitro

Abstract: p38 inhibitors are potent TNF-α suppressors in LPS-stimulated human whole blood and promote efficacy in the rat adjuvant arthritis model. However, the anti-TNF-α activity of p38 inhibitors in rat whole blood has not been explored, preventing the establishment of a potential relation between in vitro and in vivo activity data in the same species. We have pharmacologically characterized a rat whole blood assay based on LPS stimulation. While p38 inhibitors showed good activity in the human assay, they failed to … Show more

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