Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting

Rapoport, Bernardo Leon

doi:10.2147/cmar.s97543

Cited by 8 publications

(7 citation statements)

References 48 publications

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“…Neurokinin‐1 (NK‐1) receptor antagonists can also reduce nausea and vomiting. Some NK‐1 receptor antagonists work by binding to receptors located on vagal afferent terminals in the GI tract (Rapoport, ). The NK‐1 receptor antagonist aprepitant decreases nausea and vomiting by crossing the blood–brain barrier and occupying NK‐1 receptors in the brain (Aprepitant Full Prescribing Information, 2017).…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

The pathophysiology, incidence, impact, and treatment of opioid‐induced nausea and vomiting

Mallick-Searle

Fillman

2017

Journal of the American Association of Nurse Practitioners

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Purpose Opioid medications are integral in managing acute moderate‐to‐severe pain. Opioid analgesics bind to μ (mu), κ (kappa), or δ (delta) opioid receptors in the brain, spinal cord, and digestive tract. However, opioids cause adverse effects that may interfere with their therapeutic use. Some adverse effects wane over time, but patients using opioids for acute pain struggle with opioid‐induced nausea and vomiting (OINV) the entire time they take the opioid. This article discusses the underlying mechanisms, clinical implications, and treatment strategies of OINV. Data sources Systematic search and review of Medline, PubMed, and Google Scholar for articles relating to OINV. In addition, package inserts provided pharmacologic data and dose recommendations as needed. Conclusions Research suggests approximately 40% of patients may experience nausea and 15%–25% of patients may experience vomiting after opioid administration. Nausea often precedes vomiting, although they can occur separately. Many patients receiving opioids rate the nausea and vomiting as worse than their pain. Nausea and vomiting can lead to complications including electrolyte imbalances, malnutrition, and volume depletion, and can also negatively affect quality of life and postoperative recovery. Implications for practice There are several medications that can be used to treat OINV including serotonin receptor antagonists, dopamine receptor antagonists, and neurokinin‐1 receptor antagonists. Healthcare providers should be proactive about discussing OINV with patients, as this may improve patient outcomes and pain relief.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

The pathophysiology, incidence, impact, and treatment of opioid‐induced nausea and vomiting

Mallick-Searle

Fillman

2017

Journal of the American Association of Nurse Practitioners

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“…see Table 1), 18,20,22,[25][26][27][28][29][30][31][32] potentially minimizing a patient's length of time in the PACU. Compared with oral antiemetic formulations, intravenous antiemetics may be administered more quickly, require less time before anesthesia (resulting in shorter overall preoperative time), and may avoid other potential metabolic requirements (eg, nasogastric tubes).…”

Section: Current G U Ideline S and Imp Ortant Con S Ider Ati On S For...mentioning

confidence: 99%

Neurokinin‐1 receptor antagonists for the prevention of postoperative nausea and vomiting

et al. 2023

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Despite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post‐anesthesia care units and ultimately increasing the cost of care. Enhanced recovery protocols and PONV management guidelines are now centered on the assessment of the individual patient's risk for developing PONV, as well as multimodal prophylaxis using antiemetics targeting different mechanisms of action. Over the last two decades, the neurokinin‐1 receptor (NK1R) has emerged as a therapeutic target for the management of PONV. This review of the literature explains the role of the NK1R and its ligand—substance P—in vomiting, describes the pharmacologic and pharmacokinetic properties of NK1R antagonists (NK1RAs) and summarizes the clinical evidence supporting NK1RAs for PONV prophylaxis in patients undergoing surgery. In particular, we discuss the therapeutic application of NK1RA in PONV prophylaxis protocols owing to their advantages over other antiemetic classes in efficacy, duration of efficacy, safety, pharmacology, and ease of administration. Future studies will be aimed at further investigating the efficacy and safety of NK1RA‐based multimodal combinations, particularly among vulnerable populations (e.g., children and elderly).

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“…Acupuncture at the above acupoints can make the Qi and blood of local breast stasis run smoothly, and regulate the whole blood Qi of the body, so that it can get normal circulation, achieve the special effect of relieving depression and soothing liver, promoting qi and relieving pain, so as to play a role in the treatment of breast fibroma. Studies have shown that moxibustion has the function of improving immunity, and moxibustion has the function of regulating and promoting endocrine, reproduction, digestion, absorption and other system functions, and improving the function of circulatory system [12][13][14][15][16] . Ginger partitioned moxibustion used in this study is a kind of object partitioned moxibustion, which mainly through the combination of drugs and treatment methods to improve the therapeutic effect.…”

Section: Clinical Observation Of Ginger Partitioned Moxibustion Combined With Acupuncture In the Treatment Of Breast Fibromamentioning

confidence: 99%

Clinical Observation of Ginger Partitioned Moxibustion Combined with Acupuncture in the Treatment of Breast Fibroma

Li¹,

Zhang²,

Sun³

et al. 2021

ijps

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To investigate the clinical efficacy of ginger partitioned moxibustion combined with acupuncture in the treatment of breast fibroma. 128 cases of breast hyperplasia combined with breast fibroma in our hospital from June 2018 to June 2020 were selected as the research object, and they were randomly divided into the observation group and the control group, 64 cases in each group. The patients in the control group were given Rupixiao, 5 tablets each time, 3 times a day, while the patients in the observation group were treated with ginger partitioned moxibustion combined with acupuncture for 3 mo. The levels of sex hormones (luteinizing hormone, estradiol, prolactin and progesterone), the pathological characteristics of color Doppler ultrasound and the changes of quality of life of the two groups before and after treatment were observed and analyzed, and the therapeutic effect was evaluated. After treatment, the estradiol and prolactin levels of the two groups were lower than before treatment, Progesterone and luteinizing hormone levels were higher than before treatment, and the estradiol and prolactin levels of the observation group were lower than those of the control group, progesterone and luteinizing hormone levels were higher than those of the control group, the differences were statistically significant (p<0.05); After treatment, the thickness of mammary gland layer, the diameter of mass, the inner diameter of breast duct and the diameter of hypoechoic area of the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (p<0.05); After treatment, the quality of life Generic Quality of Life Inventory-74 scores (including material life, physical function, social function, psychological function and total score) of the two groups were significantly improved (p<0.05), and the observation group was significantly better than the control group in improving the quality of life scores; The total effective rates of the observation group and the control group were 95.0 % and 83.3 % respectively, and the difference between the two groups was statistically significant (p<0.05). Ginger partitioned moxibustion combined with acupuncture in the treatment of patients with breast fibroma has a good effect, which can effectively improve the level of sex hormones, promote the recovery of the disease, and improve the quality of life of patients.

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Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting

Cited by 8 publications

References 48 publications

The pathophysiology, incidence, impact, and treatment of opioid‐induced nausea and vomiting

The pathophysiology, incidence, impact, and treatment of opioid‐induced nausea and vomiting

Neurokinin‐1 receptor antagonists for the prevention of postoperative nausea and vomiting

Clinical Observation of Ginger Partitioned Moxibustion Combined with Acupuncture in the Treatment of Breast Fibroma

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